[-] Biomedical Impact of Nanoparticles

The objectives of this project are focused on gaining a detailed biophysical knowledge of the long term interactions of nanoparticles with self-assembled biological structures, such as lipid bilayer, using Molecular Dynamics approaches. Understanding how these particles penetrate and modify the structural, thermodynamic, dynamical and mechanical properties of these biomolecular systems will help us to comprehend their potential harmful effects, as well as to develop methods for their remediation.

This work is supported by the National Science Foundation, NSF-CAREER.

Publications related to this project:

46. S.L Fiedler and A.Violi “Simulation of Nanoparticle Permeation through a Lipid Membrane”, Biophysical Journal 99: 144-152 (2010). [Download .PDF]

38. S. Choe, R. Chang, J. Jeon, A. Violi “Molecular Dynamics Simulation Study of a Pulmonary Surfactant Film Interacting with a Carbonaceous Nanoparticle”, Biophysical Journal 95: 4102-4114 (2008). [Download .PDF]

28. R. Chang, A. Violi “ Insights into the effect of combustion-generated carbon nanoparticles on biological membranes: a computer simulation”, Journal of Physical Chemistry B, 110(10). 5073-5083 (2006).

See Also:

• Publications