BMS 513- Biology of the Salivary Glands Spring 2003


Course Instructors
Dennis E. Lopatin, Ph.D., Course Director


Department of Biologic & Materials Sciences
University of Michigan School of Dentistry
Room 4209 Dental Building
(734) 647-3912 
Christopher Nosrat, D.D.S., Ph.D. 
Department of Biologic & Materials Sciences
University of Michigan School of Dentistry 
Room 3218 Dental Building
(734) 615-4388
Domenica G. Sweier, D.D.S. 
Department of Biologic & Materials Sciences
University of Michigan School of Dentistry 
Room 4208 Dental Building
(734) 764-4414
Nisha J. D'Silva, M.S.D., Ph.D.
Department of Oral Medicine/Pathology/Oncology
University of Michigan School of Dentistry 
Room 5217 Dental Building
(734) 615-1414

If you have any questions or comments regarding lectures, please e-mail them to Dr. Lopatin ( so that they can be added to this web page and the answers can be made available to the entire class.

Download Lecture Schedule and Reading Assignments

We hope to have the files for each lecture available by the day of the lecture. Many of the lectures are updated prior to class. If you download a lecture more than a week before class, you should check to see if a later version of a lecture has been uploaded to the website after the lecture has been given.

Some of the files are large (several megabytes). Unless you have a high-speed internet connection at home, download the files in CAIDENT.

Lecture No.
Date Instructor Title of Lecture PPT File
MAY 5, 2003 (Monday) Lopatin Introduction to the Salivary Gland



May 7, 2003 (Wednesday) Lopatin Composition and Functions of Saliva Download


May 12, 2003 (Monday) Nosrat Salivary Ion and Fluid Secretion Download


May 14, 2003 (Wednesday) Nosrat Excitation-Secretion Coupling Download


May 19, 2003 (Monday)   No Class - Catch up on reading assigned articles


May 21, 2003 (Wednesday) Lopatin Mucosal Immune System Download


May 26, 2003 (Monday) Memorial Day  


May 28, 2003 (Wednesday) Mid-Term Examination  


June 2, 2003 (Monday) D'Silva Cell Biology of Salivary Protein Secretion Download



June 4, 2003 (Wednesday) Sweier Aging and Diseases of the Salivary Glands




June 9, 2003 (Monday) Sweier Pharmacologically-Mediated Salivary Dysfunction and the Pharmacologic Management of Salivary Diseases




June 11, 2003 (Wednesday) Lopatin Saliva as a Diagnostic Fluid



June 17, 2002 (Monday) Lopatin Mucosal vaccines: Prevention of Caries & Periodontal Disease




June 19, 2002 (Wednesday) Lopatin Future Directions in Salivary Gland Research Download


I have provided copies of past exams for your enjoyment. Please remember that the course has evolved over time. New topics have been added and some have been retired. I recommend that you use the exams as study guides to help you identify topics and issues that the course faculty feel are important. Do not expect to see the same questions again (unless the multiple choice answers are changed.) You should also remember that this year's final will be comprehensive.

Download copies of previous examinations (PDF format)
1998 1999 2000 2001 2002 2003
Midterm Midterm Midterm Midterm Midterm Midterm
Final Final Final Final Final Final

Download Examination Scores (PDF format)

MidTerm and Final 2003 Grades

On the Midterm: There were "issues" with questions #29, 32, 35. I gave everyone credit for them. Also, I accepted B or D for #38

Final Grades are based on percents. There was a total of 90 points (midterm + final)

A= 90% or higher

B= 80-89%

If you have any "issues" you may contact me by e-mail, almost anytime.

I want to thank you for being such an interesting class! I am pleased with how you did in the exams and hope to be able to interact with all of you throughout your dental careers (even after you graduate). Trust will happen!

"Doc" Lopatin



Required Text

W.M. Edgar and D.M. O'Mullane (eds.). Saliva and Oral Health;London; British Dental Association; 1996.

Recommended texts

Bradley, R.M. Essentials of oral physiology. St. Louis; Mosby-Year Book; 1995. (You will need to purchase this book for Dr. Bradley's course in the Fall term. You might want to buy it now.)

Dobrosielski-Vergona, K. (ed.) Biology of the salivary glands. Boca Raton; CRC Press; 1993.

Malamud, D. and Tabak, L. (eds.) Saliva as a diagnostic fluid. New York; Annals of the New York Academy of Sciences; Vol. 694, 1993.
Additional Readings have been placed on reserve in the Dentistry Library.



University of Michigan School of Dentistry
Department of Biologic & Materials Sciences
1011 North University Avenue
Ann Arbor MI 48109-1078
Phone: 734 763 5280 | Fax: 734 763 3453