Step 1: Citrate Synthase: Entry of substrate by condensation
with oxaloacetate.
Step 2: Aconitase: Rearrangement
Step 3: Isocitrate dehydrogenase: First oxidative decarboxylation.
Step 4: Alpha-Ketoglutarate dehydrogenase complex: Second
oxidative decarboxylation
Step 5: Succinyl-CoA Synthetase: Substrate-level phosphorylation.
Step 6: Succinate dehydrogenase complex: Sustrate-level
phosphorylation
Q= FAD
Step 7: Fumarase: Hydration
Step 8: Malate dehydrogenase: Oxidation
This reaction results in the creation of:
2 molecules CO2
1 molecule ATP (used by the body as energy)
3 molecules NADH (used to create ATP)
1 molecule FADH2 (used to create ATP)
Purdue University, West Lafayette, IN
http://chemed.chem.purdue.edu/organic/orgapp/body_energy/citric_acid/citric.html
Step 1:
Step 2:
Step 3:
Step 4:
Step 5:
Step 6:
Step 7:
Step 8:
This is a cycle - now the oxaloacetate
produced in Step 8 can be used again in Step 1, and the process can reoccur.