Complete Data Set

P7-25

  1. First Show

  2. Methanol has been ingested, and after pumping the stomach methanol has an initial concentration of CMi = 0.25 g/dm3 in the body.
    1. How many grams of ethanol are necessary to retard the formation of formaldehyde so that it will not reach the level to cause blindness if the ethanol is to be injected immediately?
    2. What feed rate of ethanol should be used to prevent formaldehyde from reaching a concentration of 0.16 g/dm3?
  3. Use the following values for Vmax1 and KM1 for ethanol neglecting the reverse reaction of acetaldehyde to ethanol. As a first approximation, use the same values for methanol. Next, vary Vmax2 the initial methanol concentration (0.1 g/dm3 < CM < 2 g/dm3), (0.1 Vmax1 < Vmax2 < 2Vmax1), k7, and the intravenous injection rate, rIV.
  4. There are 10 mg of methanol per 12 ounce can of diet pop. How many cans and how fast must you need to drink then to cause blindness. Just estimate, no need to modify and run the Polymath program.
Additional Information

KM1 (ethanol) = 1.53 mg/dm3; KM2 (methanol) = 1.07 mg/dm3; Vmax1 (ethanol) = 3.1 mg/(dm3 • min); Vmax2 (methanol) 2.16 mg/(dm3 • min)

k7 = 3.47 × 10-5/min [Kidney removes 0.0833 liters of fluid per hour]. Assume the concentration in the urine is the same as the blood.]