Example CD Solved Problems - Blood Coagulation |POLVER05_3 d(TF)/d(t) = r2-r1-r3+r4 # d(VII)/d(t) = r2-r1-r6-r7-r5 # d(TFVII)/d(t) = r1-r2 # d(VIIa)/d(t) = -r3+r4+r5+r6+r7 # d(TFVIIa)/d(t) = r3-r4+r9-r8-r11+r12-r13+r14-r42-r37+r15 # d(Xa)/d(t) = r11+r12+r22-r27+r28-r33+r34-r38 # d(IIa)/d(t) = r16+r32-r41 # d(X)/d(t) = -r8+r9-r20+r21+r25 # d(TFVIIaX)/d(t) = r8-r9-r10 # d(TFVIIaXa)/d(t) = r10+r11-r12-r35+r36 # d(IX)/d(t) = r14-r13 # d(TFVIIaIX)/d(t) = r13-r14-r15 # d(IXa)/d(t) = r15-r18+r19+r25-r40 # d(II)/d(t) = r30-r29-r16 # d(VIII)/d(t) = -r17 # d(VIIIa)/d(t) = r17-r18+r19-r23+r24 # d(IXaVIIIa)/d(t) = -r20+r21+r22+r18-r19 # d(IXaVIIIaX)/d(t) = r20-r21-r22-r25 # d(VIIIa1L)/d(t) = r23-r24+r25 # d(VIIIa2)/d(t) = r23+r25-r24 # d(V)/d(t) = -r26 # d(Va)/d(t) = r26-r27+r28 # d(XaVa)/d(t) = r27-r28-r29+r30+r31 # d(XaVaII)/d(t) = r29-r30-r31 # d(mIIa)/d(t) = r31-r32-r39 # d(TFPI)/d(t) = r34-r33-r35+r36 # d(XaTFPI)/d(t) = r33-r34-r37 # d(TFVIIaXaTFPI)/d(t) = r35-r36+r37 # d(ATIII)/d(t) = -r38-r39-r40-r41-r42 # d(XaATIII)/d(t) = r38 # d(mIIaATIII)/d(t) = r39 # d(IXaATIII)/d(t) = r40 # d(TFVIIIaATIII)/d(t) = r42 # d(IIaATIII)/d(t) = r41 # r1 = k1*TF*VII # r2 = k2*TFVII # r3 = k3*TF*VIIa # r4 = k4*TFVIIa # r5 = k5*TFVIIa*VII # r6 = k6*Xa*VII # r7 = k7*IIa*VII # r8 = k8*TFVIIa*X # r9 = k9*TFVIIaX # r10 = k10*TFVIIaX # r11 = k11*TFVIIa*Xa # r12 = k12*TFVIIaXa # r13 = k13*TFVIIa*IX # r14 = k14*TFVIIaIX # r15 = k15*TFVIIaIX # r16 = k16*Xa*II # r17 = k17*IIa*VIII # r18 = k18*IXa*VIIIa # r19 = k19*IXaVIIIa # r20 = k20*IXaVIIIa*X # r21 = k21*IXaVIIIaX # r22 = k22*IXaVIIIaX # r23 = k23*VIIIa # r24 = k24*VIIIa1L*VIIIa2 # r25 = k25*IXaVIIIaX # r26 = k26*IIa*V # r27 = k27*Xa*Va # r28 = k28*XaVa # r29 = k29*XaVa*II # r30 = k30*XaVaII # r31 = k31*XaVaII # r32 = k32*mIIa*XaVa # r33 = k33*Xa*TFPI # r34 = k34*XaTFPI # r35 = k35*TFVIIaXa*TFPI # r36 = k36*TFVIIaXaTFPI # r37 = k37*TFVIIa*XaTFPI # r38 = k38*Xa*ATIII # r39 = k39*mIIa*ATIII # r40 = k40*IXa*ATIII # r41 = k41*IIa*ATIII # r42 = k42*TFVIIa*ATIII # k1 = 3.2e6 #(s-1) k2 = 3.1e-3 #(M-1 s-1) k3 = 2.3e7 #( s-1) k4 = 3.1e-3 #(M-1 s-1) k5 = 4.4e5 #(s-1) k6 = 1.3e7 #(M-1 s-1) k7 = 2.3e4 #(M-1 s-1) k8 = 2.5e7 #( s-1) k9 = 1.05 #(M-1 s-1) k10 = 6 #(s-1) k11 = 2.2e7 #( s-1) k12 = 19 #(M-1 s-1) k13 = 1.0e7 #( s-1) k14 = 2.4 #(M-1 s-1) k15 = 1.8 #(s-1) k16 = 7.5e3 #(M-1 s-1) k17 = 2e7 #(M-1 s-1) k18 = 1.0e7 #(s-1) k19 = 5e-3 #(M-1 s-1) k20 = 1e8 #(s-1) k21 = 1e-3 #(M-1 s-1) k22 = 8.2 #( s-1) k23 = 6e-3 #(M-1 s-1) k24 = 2.2e4 #(s-1) k25 = 1e-3 #( s-1) k26 = 2e7 #(M-1 s-1) k27 = 4e8 #( s-1) k28 = 0.2 #(M-1 s-1) k29 = 1e8 #(s-1) k30 = 103 #(M-1 s-1) k31 = 63.5 #(s-1) k32 = 1.5e7 #(M-1 s-1) k33 = 9e5 #( s-1) k34 = 3.6e-4 #(M-1 s-1) k35 = 3.2e8 #( s-1) k36 = 1.1e-4 #(M-1 s-1) k37 = 5e7 #(M-1 s-1) k38 = 1.5e3 #(M-1 s-1) k39 = 7.1e3 #(M-1 s-1) k40 = 4.9e2 #(M-1 s-1) k41 = 7.1e3 #(M-1 s-1) k42 = 2.3e2 #(M-1 s-1) Total = IIa+1.2*mIIa # t(0)=0 TF(0)=25e-12 VII(0)=1e-8 TFVII(0)=0 VIIa(0)=1e-10 TFVIIa(0)=0 Xa(0)=0 IIa(0)=0 X(0)=1.6e-7 TFVIIaX(0)=0 TFVIIaXa(0)=0 IX(0)=9e-8 TFVIIaIX(0)=0 IXa(0)=0 II(0)=1.4e-6 VIII(0)=0.7e-9 VIIIa(0)=0 IXaVIIIa(0)=0 IXaVIIIaX(0)=0 VIIIa1L(0)=0 VIIIa2(0)=0 V(0)=2e-8 Va(0)=0 XaVa(0)=0 XaVaII(0)=0 mIIa(0)=0 TFPI(0)=2.5E-9 XaTFPI(0)=0 TFVIIaXaTFPI(0)=0 ATIII(0)=3.4E-6 XaATIII(0)=0 mIIaATIII(0)=0 IXaATIII(0)=0 TFVIIIaATIII(0)=0 IIaATIII(0)=0 t(f)=700