Hypertrophic response in bone

• mediated by

  • activation by stress of osteoclasts
  • secretion by osteoclasts and monocytes of cytokines IL-1, IL-6, prostaglandin E2
  • removal of unstressed parts of bone
  • secretion by osteoblasts of IGF-I, TGFbeta, PGE , osteocalcin, BMPs
  • bone formation

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