3. Barriers to CNS Drug Delivery / Transporters
Course Coordinator: B. Elmquist (Nebraska)
Faculty Participants: B. Elmquist, R. Keep (Michigan), D. Smith (Michigan), K. Audus (Kansas), R. Borchardt (Kansas), D. Miller (Nebraska)
Program:
12:30 - 1:00 PM Lecture 1. Overview of pertinent CNS anatomy/physiology/transport. R. Keep (Michigan)
1:00 - 1:30 PM Lecture 2. Peptide transporters in the CNS. D. Smith (Michigan)
1:30 - 1:45 PM Break
1:45 - 2:15 PM Lecture 3. In vitro models and drug transport in the CNS. K. Audus (Kansas)
Lecture 4. Permeability of cyclic peptides in the CNS: a case study. R. Borchardt (Kansas)
2:15 - 2:45 PM
2:45 - 3:15 PM Lecture 5. Second messengers, signal transduction, and the permeability of the BBB. D. Miller (Nebraska)
3:15 - 3:45 PM Lecture 6. In vivo models and drug transport in the CNS. B. Elmquist (Nebraska)
3:45 - 4:00 PM Panel Discussion