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| 5. | Stability of Peptides, Proteins and Nucleotides | ||||||
| Course Coordinator: | C. Schoneich (Kansas) | ||||||
| Faculty Participants: | C. Schöneich, E. M. Topp (Kansas), T. Siahaan (Kansas), R. Middaugh (Kansas), M. Manning (U. Colorado), M. Pikal (U. Connecticut), E. Munson (Kansas) | ||||||
| Program: | |||||||
| 8:00 - 8:10 AM | Introduction. C. Schoneich (Kansas) | ||||||
| 8:10 - 9:00 AM | Lecture 1. Hydrolytic and solvolytic degradation of peptides and proteins in solution, polymers and solids. E.M. Topp (Kansas) | ||||||
| 9:00 - 9:50 AM | Lecture 2. Oxidative and photolytic degradation of peptides and proteins in solution, polymers and solids. C. Schöneich (Kansas) | ||||||
| 9:50 - 10:20 AM | Break | ||||||
| 10:20 - 11:10 AM | Lecture 3. Biophysical methods to study peptide and protein degradation. M. Manning (U Colorado) | ||||||
| 11:10 - 12:00 PM | Lecture 4. Effect of conformation on the degradation of peptides and proteins. T. Siahaan (Kansas) | ||||||
| 12:00 - 1:00 PM | Lunch | ||||||
| 1:00 - 1:50 PM | Lecture 5. Solid state NMR to study peptide and protein degradation. E. Munson (Kansas) | ||||||
| 1:50 - 2:40 PM | Lecture 6. Principles of solid state reactions of peptides and proteins. M. Pikal (U Connecticut) | ||||||
| 2:40 - 3:20 PM | Break | ||||||
| 3:20 - 4:10 PM | Chemical degradation of polynucleotides. D. Fischer (Marburg, Germany ) | ||||||