Circular Dichroism Instrumentation


    Analysis of protein secondary structure is commonly accomplished by measuring the chiral absorbance of far Ultraviolet (far-UV) due to the sensitivity of the peptide chromophore backbone. 



CD spectra
Subtle changes in protein secondary structure induced by amino acid substitutions of Plasminogen Activator Inhibitor are followed by Circular Dichroism



Analysis of protein secondary structure has been actively persued by a number of groups (Fasman, etc links).