113 A Ceramic Drug Delivery System For Bone Augmentation

Thursday, March 22, 2012: 8 a.m. - 9:30 a.m.
Presentation Type: Oral Session
M. DRAENERT, LMU Munich, Munich, Germany, F. FORRIOL, Traumatology, University of Madrid, Madrid, Spain, and K. DRAENERT, Research and Developments, ZOW, Munich, Germany

Bone augmentation for periodontal operative treatment and implantology is still a challenge. The physiological reconstruction of  jawbone is either built up with ceramics or transplants. The induction of bone formation in situ is still a matter of investigation. A new ceramic carrier for BMP is introduced yielding primary cancellous bone, which is finally transferred into compact bone. 


A standardized defect (8,35 x 20 mm) has been performed in the patellar groove and the tibiahead of 10 sheep using diamond instruments and a wet grinding technology. The defect was closed towards the joint by a press-fit inserted ß-TCP cover thus avoiding diffusion of the BMP-7. ß-TCP microchambered beads (MCB) with BMP-7 were inserted. Non-demineralized high-resolution-histology after 6 and 9 weeks, 3 months and 1 year was performed.


After 6 weeks, a primary cancellous scaffold of mature lamellar bone has formed around the ceramic MCBs. There was no ectopic bone formation indicating diffusion of BMP. After 9 weeks, remodelling and ß-TCP resorption was nearly finished. The three months- and one-year results revealed a newly formed bone, spongious in the metaphysis and compact cortical along the diaphyseal tube or epiphyseal compacta. Compared with the plain ceramic, there was a 4-6 weeks faster bone healing, remodelling and reabsorption of ß-TCP on the BMP side. 

Reviewing the current literature, the approach to combine a bone forming osteoconductive element with drug delivery of BMP, is innovative and more efficient than the current application of BMP.


Ceramic beads combine drug delivery and bone forming elements in a very efficient way. The remodelling process is enhanced and even the reabsorption of ß-TCP stimulated. The application is easy, the bone formation fast and the BMP is safely hold in the chambers of the MCBs.

Keywords: Biomaterials and Oral surgery
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