559 Effect of CPC Mouthwash on Periodontal Health in Pregnant Women

Thursday, March 22, 2012: 3:30 p.m. - 4:45 p.m.
Presentation Type: Poster Session
N. TANNA, University of Pennsylvania, Philadelphia, PA, A. WALANSKI, Procter & Gamble Company, Mason, OH, S. PARRY, Obgyn, University of Pennsylvania, Philadelphia, PA, R. GERLACH, Health Care Research Center, Procter & Gamble Company, Mason, OH, M. DOYLE, Health Care R&D Worldwide, The Procter & Gamble Company, Mason, OH, and M. JEFFCOAT, School of Dental Medicine, University of Pennsylvania, Philadelphia, PA

The aim of this study was to determine if a CPC mouthwash without alcohol decreased gingival inflammation and periodontal disease in pregnant women.


160 pregnant women (6-20 weeks gestation) were studied. At baseline, medical and dental histories were taken.  Periodontal exams and informed consent were completed.  All subjects received standardized toothpaste and toothbrushes and were instructed to rinse either with a non-alcoholic CPC mouthrinse (Crest ProHealth, Procter and Gamble, Cincinnati, Ohio) or served as controls. Oral hygiene instructions were provided.  At baseline and 3 months periodontal status was evaluated by clinical measurements of probing depths, probing attachment levels (PAL) and bleeding on probing.  The independent variables were (1) rinse or (2) control. The dependent variables of interest were (1) mean number of sites per patients that bled on probing and (2) mean number of sites per patient with PAL >4mm. An analysis of variance was used to determine the statistical significance. Post hoc tests were performed.


A significant decrease (improvement) over the course of the study in periodontal probing (pocket) depth and attachment level (PAL) was observed in the rinse group (p<0.001 and p<0.05, respectively), but not in the control groups. The control group had a significant increase in bleeding on probing which was not exhibited by the rinse group (Table). The controls also exhibited an increase in the number of sites with attachment loss>4mm.


The use of a CPC mouthwash showed an overall improvement in periodontal health and inflammation in pregnant women.

Supported by Procter and Gamble

                                                            Periodontal status according to treatment group


non-alcohol CPC rinse















#sites with attachment loss >4 mm














#sites with bleeding on probing










This abstract is based on research that was funded entirely or partially by an outside source: Procter and Gamble

Keywords: Inflammation, Periodontal disease, Pregnancy and Therapeutics