1449 Overnight Anti-Plaque Benefits of Two Marketed Dentifrices using DPIA

Saturday, March 24, 2012: 9:45 a.m. - 11 a.m.
Presentation Type: Poster Session
I.M. TSAKNAKI1, A. ALHAFNE1, C. ERBE1, M. KLUKOWSKA2, M.L. BARKER3, H. TIMM4, C. JACOBS1, and H. WEHRBEIN1, 1Department of Orthodontics, University Medical Centre Mainz, Mainz, Germany, 2Oral Biology, Procter & Gamble Company, Mason, OH, 3Oral Care Clinical Research, Procter & Gamble Company, Mason, OH, 4Procter & Gamble, Kronberg, Germany
Objectives: This research evaluated overnight anti-plaque efficacy of a stannous containing sodium fluoride dentifrice compared to a chlorhexidine digluconate containing aluminum fluoride dentifrice using an objective Digital Plaque Image Analysis (DPIA).

Methods: This study was a randomized, 4-period crossover design, which examined overnight anti-plaque efficacy of two dentifrices: a) Oral-B Blend-a-med Pro Expert Rundumschutz (PER) and b) Lacalut Aktiv (LA). After a 2-week acclimation period subjects were randomly assigned to one of four treatment sequences and instructed to brush teeth thoroughly twice a day (morning and evening) for the treatment periods. Each treatment period was 17 days in duration and followed by a 4-day wash-out period. ANOVA for crossover designs was used to analyze for treatment differences of overnight plaque.

Results: 36 healthy subjects from a general adult population with the evidence of overnight plaque were enrolled and all of them completed the study. Mean age was 29 years ranging from 18-58, 69% of subjects were female. After 17 days of product use the mean overnight plaque was 18.2% for PER and 19.7% for LA dentifrice. Treatments differed significantly (p<0.05) favoring PER with a relative difference of 7.9% versus LA.

Conclusions: The stannous containing sodium fluoride PER dentifrice had statistically significantly lower overnight plaque level than the chlorhexidine digluconate containing aluminum fluoride dentifrice (LA) after 17 days of product use.

Keywords: Dentifrices, Digital image analysis, Fluoride, Oral hygiene and Plaque