424 A Study on Antimicrobial Effectiveness of Denture Cleansers in Partials

Thursday, March 22, 2012: 3:30 p.m. - 4:45 p.m.
Presentation Type: Poster Session
K. BAXTER1, P. FERNANDEZ2, J.P. DUROCHER2, J. VERRAN3, F. GONSER4, and R. KAPIKIAN5, 1Hilltop Research, Inc, Miamiville, OH, 2Medical Affairs, GlaxoSmithKline, Parsippany, NJ, 3Dept. of Biology, Chemistry & Health Science, Manchester Metropolitan University, Manchester, England, Uk, 4GlaxoSmithKline Consumer Healthcare, Parsippany, NJ, 5Biostatistics and Data Mgmt, GlaxoSmithKline, Parsippany, NJ
Objective:  Partial denture wearers often have complex dentitions with an increased potential of disease in remaining teeth and denture supporting tissue.  A study was conducted to determine if cleansing a removable partial denture (RPD) would aid in reductions of microbial populations on abutment teeth, identified as most vulnerable.

Method:  This was a three-arm, modified-crossover in 35 healthy subjects wearing RPDs.  Subjects were randomized in the first two periods of crossover to immersion in test product (Polident® cleanser tablet, GSK) or negative control (Water), while in the third period, to positive control (Peridex®, Chlorhexidine-Gluconate 0.12%, Zila).  Subjects performed twice-daily treatments to their RPD while brushing natural teeth with toothpaste, having one week wash-out between treatments.  Plaque samples were collected from an abutment tooth and RPD prior to study, and 21 days post-treatment.  Microbial counts (streptococci, gram-negative anaerobes, yeast) on abutment tooth and RPD surface were evaluated for efficacy.  Mixed-model with treatment as fixed effect and subject as random effect was applied to the efficacy parameters.  An adjustment for multiple comparisons was performed. 

Result:  Polident® was superior to Water, (insignificantly different from Peridex®) in counts of target microbial groups (gram-negative anaerobes, oral streptococcus) on RPD proximal surfaces and between adjacent denture teeth surfaces (p<0.0025).  There were no statistically significant differences between Polident® and Water or between Polident® and Peridex® for target microbial groups (gram-negative anaerobes and oral streptococcus) on natural abutment teeth. There were also no significant differences between Polident® and Water, nor between Polident® and Peridex®, with regards to log counts for yeast colonization on any sampled sites (p>0.0025), which was attributed to yeast counts being below detection levels (<1000CFU/mL).  All regimens were well tolerated

Conclusion:  Polident® performed similar to Peridex® in producing lower quantities of bacteria on RPD surfaces (relative to water), but was not significant on abutment tooth surface measures.

Keywords: Bacterial, Microbiology, Prostheses and abutment tooth
Presenting author's disclosure statement: I am an employee of GlaxoSmithKline.
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