1091 Phophate Ion Release From Ion-permeable Microcapsules In Varnish Formulations

Friday, March 23, 2012: 3:30 p.m. - 4:45 p.m.
Presentation Type: Poster Session
M.A. LATTA1, S. GROSS1, T. GREVING1, M. FALBO1, P. ELASSAL1, and W. MCHALE2, 1School of Dentistry, Creighton University, Omaha, NE, 2Product Development, Premier Dental Products Company, Plymouth Meeting, PA

 

Objectives: The objective of this study was to determine the effect of initial concentration of phosphate ion on the release from microcapsules with ion permeable membranes formulated in resin and rosin based varnish formulations.  Methods: A heterogeneous polymerization technique was utilized to prepare microcapsules containing an aqueous solution of 0.8 M, 2.4 M, 4.0 M and 7.4 M potassium phosphate dibasic.  Fifteen weight percent of microcapsules were formulated into both a resin and rosin based varnish formulation for a total of seven formulations.  Ion release profiles were studied as a function of initial salt concentration and time for 12 weeks. Phosphate ion detection was performed by the molybdenum blue method and reported as ppm of phosphate ion released per gram of formulation.  Results:   Ion release profiles were studied as a function of initial salt concentration in the varnish formulations and are reported below:

Continuous Phase

Initial Conc in microcapsule (M)

Weight % of microcapsules

1 day (ppm)

1 week (ppm)

6 weeks (ppm)

12 weeks (ppm)

Resin

0.8

15

14

19

55

88

Resin

2.4

15

46

70

227

367

Resin

4.0

15

32

79

295

490

Rosin

0.8

15

21

133

296

318

Rosin

2.4

15

110

511

821

829

Rosin

4.0

15

76

329

697

800

Rosin

7.4

15

19

193

977

1128

Conclusions: Ion release profiles were generated for varnish formulations containing microencapsulated aqueous solutions that contained phosphate ions that may be useful in remineralization.  The preparation of varnish formulations with controlled release profiles appears promising based on the variation of initial molarity of salt solution encapsulated in the microcapsule fillers.  This work is funded in part by Premier Dental Products Incorporated, GL Materials Research LLC and an NSF University-Industry Partnership grant.

 

This abstract is based on research that was funded entirely or partially by an outside source: NSF/EPSCOR Univeristy-Industry partnership grant

Keywords: Dental materials, Mineralization, Remineralization and Varnish
Presenting author's disclosure statement: I am a member manager in an LLC which was a part of the NSF/ESPCOR program