Circulating Levels of Adipocytokines in Non-Obese Subjects with Chronic Periodontitis

Objectives: Previous studies have demonstrated that adipocytokines, like adiponectin, leptin and resistin affect the inflammatory process and the innate and adaptive immunity. However, to date, if and to what extent periodontitis subjects present an altered profile of circulating adipocytokines should to be better elucidated. The aim of this study was to evaluate the levels of adipocytokines in the serum of non-obese subjects with chronic periodontitis, when compared to periodontally healthy ones. Methods: Twenty non-obese subjects with chronic periodontitis and 20 non-obese periodontally healthy subjects were enrolled in this study. Serum levels of adiponectin, leptin and resistin were evaluated by enzyme linked immunosorbent assay. Results: Serum levels of resistin and leptin were significantly higher in chronic periodontitis subjects when compared to healthy controls (P <0.05). There were no differences in the levels of adiponectin between groups (P >0.05). Conclusions: Chronic periodontitis upregulated the circulating levels of resistin and leptin in subjects with normal body mass index and waist hip ratio.