Association of Periodontitis with Angiographic Extent of Stable Artery Disease

Objective: Making a correlation between oral infections and cardiovascular disease seems long overdue since bacteremias associated with scaling, extractions, periodontal surgery has been recognized and documented for decades. The aim of the present cross-sectional investigation was to examine the association between periodontal disease and coronary artery disease by using angiographic data and inflammatory marker evaluation.

Method: Study subjects were163 patients that were scheduled to have a coronary angiography in Modarres Hospital in Tehran. The indications of the patients  were :history of stable typical chest pain, atypical chest pain with positive myocardial SPECT scan imaging and positive exercise tolerance test.Before undergoing coronary angiography, medical history and cardiovascular risk factors such as age, sex, weight, height, body mass index(BMI), smoking history, diabetes history, and hypertension were reviewed.Interleukin-6 was also measured. . For periodontal assessment,bleeding on probing, missing teeth, clinical attachment level(CAL) and percentage of teeth with CAL was measured. This information will be transferred into SPSS datasheet which will be then ready for statistical analysis. Multiple Regression Model was used in the evaluation of the independent effect of the dental variables on Friesinger score, to we could eliminate the effect of the confounding factors( Age, sex, BMI, smoking history, diabetes, systolic blood pressure, diastolic blood pressure and cholesterol level).

Results: There was a siginificant relationship between Mean Cal and the Friesinger score(B=1.85) after adjusting for age, sex, BMI ,smoking history, diabetes, systolic blood pressure (SBP), diastolic blood pressure(DBP) and cholesterol level. .. No significant relationship was shown between the other parameters. Interleukin-6 did not have a significant relationship with Friesinger score, this may be because it is elevated in the acute phase cardiovascular events.

Conclusion: The results of this study suggests that periodontitis is associated with coronary artery disease.

 

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