152 Metabolomics: Its Use to Study Oral Disease and Beyond

Saturday, March 24, 2012: 8 a.m.-9:30 a.m.
Session Type: Symposium
1.5 CE hours
Theme: My research does not fit any of these themes.
Sponsored by: Oral Health Research
Description: The "omics" have become an exciting and useful area of study in oral care.  Genomics, transcriptomics, proteomics all have delivered a wealth of knowledge and understanding regarding health , disease and effective therapies.  Metabolomics is an emerging discipline in oral care which measures the small native molecules driving the physiology of the cells.  When the metabollites are homestatic, a state of good health exists in the cell.  Conversely, if the metabolites are out of balance, the cell may be in a state of disease.  Metabolomics has a rich history in medicine, toxicology and pharmacology.  Recently, global unbiased screenings of gingival crevicular fluid and saliva have provided the metabolomic profile contrasting subjects deemed healthy as compared to subjects suffering from periodontal disease.  These data provide insight to the biochemical interactions between the host and the bacteria in periodontal disease.  Additionally, these data may provide a framework from which new diagnostic methods can be explored as well as opportunities to enhance product development of related therapeutics.  This symposium will detail the unique mass spectrometry technology and bioinformatics developed to accurately identify and interpret metbolite biomarkers.  Applications in oral care, consumer products, medicine, toxicology, drug development and diangostic assays will be explored.
Learning Objectives:
Understanding the role of Metabolomics in the published oral care research
Understanding Metaoblomics and its impact in the researhc arena of "omics"
Identifying the use of Metabolomics for a better understanding of disease states, product development and diagnostics with the challenge to find new applications, particularly in oral care
The Use of Metabolomics in Oral Care Clinical Research
V. BARNES, Colgate-Palmolive Company, Piscataway, NJ
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