.. _CARS: CARS ^^^^ .. contents:: :local: General Information ******************* :Full gene name: cysteinyl-tRNA synthetase :Entrez Gene ID: 833 :Location: 11p15.5 :Synonyms: MGC:11246, CARS1, CYSRS :Type: protein-coding User SNPs ********* SNPs given by the user that are near or inside this gene: +-----------+---------------+------------+ | SNP | Distance (bp) | Direction | +===========+===============+============+ | rs2237892 | 182401 | downstream | +-----------+---------------+------------+ .. _CARS Gene summary: NCBI Summary ************ This gene encodes a class 1 aminoacyl-tRNA synthetase, cysteinyl-tRNA synthetase. Each of the twenty aminoacyl-tRNA synthetases catalyzes the aminoacylation of a specific tRNA or tRNA isoaccepting family with the cognate amino acid. This gene is one of several located near the imprinted gene domain on chromosome 11p15.5, an important tumor-suppressor gene region. Alterations in this region have been associated with Beckwith-Wiedemann syndrome, Wilms tumor, rhabdomyosarcoma, adrenocortical carcinoma, and lung, ovarian and breast cancers. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Aug 2010] .. _OMIM ID 123859 : http://omim.org/entry/123859 .. _CARS OMIM Text: OMIM **** :OMIM ID: `OMIM ID 123859 `_ .. _CARS Phenotype: NCBI Phenotypes *************** * NHGRI GWA Catalog * Joint influence of small-effect genetic variants on human longevity. .. _CARS GO Term: Gene Ontology ************* * tRNA aminoacylation for protein translation * protein homodimerization activity * cytosol * cysteine-tRNA ligase activity * cysteinyl-tRNA aminoacylation * cytoplasm * ATP binding * protein binding * tRNA binding * gene expression * metal ion binding .. _CARS Pathway: KEGG Pathways ************* * `Aminoacyl-tRNA biosynthesis `_ .. _CARS GeneRIF: GeneRIFs ******** * Affinity Capture-MS [`PMID 19394292`_] * CARS is a novel fusion partner of anaplastic lymphoma kinase in anaplastic large-cell lymphoma and inflammatory myofibroblastic tumor cases. [`PMID 12112524`_] * Observational study of gene-disease association. (HuGE Navigator) [`PMID 20460425`_] * Specificity of anticodon recognition by human CysRS is higher than that of its bacterial counterparts. [`PMID 17303165`_] * Affinity Capture-MS [`PMID 21963094`_] * Observational study and genome-wide association study of gene-disease association. (HuGE Navigator) [`PMID 20306291`_] * Affinity Capture-MS [`PMID 19041431`_] * Affinity Capture-MS [`PMID 19041431`_] * Affinity Capture-MS [`PMID 19041431`_] * Affinity Capture-MS [`PMID 19041431`_] * Reconstituted Complex; Two-hybrid [`PMID 10908348`_] .. _PMID 19394292: http://www.ncbi.nlm.nih.gov/pubmed/19394292 .. _PMID 12112524: http://www.ncbi.nlm.nih.gov/pubmed/12112524 .. _PMID 20460425: http://www.ncbi.nlm.nih.gov/pubmed/20460425 .. _PMID 17303165: http://www.ncbi.nlm.nih.gov/pubmed/17303165 .. _PMID 21963094: http://www.ncbi.nlm.nih.gov/pubmed/21963094 .. _PMID 20306291: http://www.ncbi.nlm.nih.gov/pubmed/20306291 .. _PMID 19041431: http://www.ncbi.nlm.nih.gov/pubmed/19041431 .. _PMID 10908348: http://www.ncbi.nlm.nih.gov/pubmed/10908348 .. _CARS Pubmed: PubMed Articles *************** *Recent articles:* * Kim W et al. "Systematic and quantitative assessment of the ubiquitin-modified proteome." Mol Cell. 2011 Oct 21;44(2):325-40. `PMID 21906983`_ * Emanuele MJ et al. "Global identification of modular cullin-RING ligase substrates." Cell. 2011 Oct 14;147(2):459-74. `PMID 21963094`_ * Danielsen JM et al. "Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level." Mol Cell Proteomics. 2011 Mar;10(3):M110.003590. `PMID 21139048`_ * Davis OS et al. "A three-stage genome-wide association study of general cognitive ability: hunting the small effects." Behav Genet. 2010 Nov;40(6):759-67. `PMID 20306291`_ * Yashin AI et al. "Joint influence of small-effect genetic variants on human longevity." Aging (Albany NY). 2010 Sep;2(9):612-20. `PMID 20834067`_ * Maeda S et al. "Replication study for the association between four Loci identified by a genome-wide association study on European American subjects with type 1 diabetes and susceptibility to diabetic nephropathy in Japanese subjects with type 2 diabetes." Diabetes. 2010 Aug;59(8):2075-9. `PMID 20460425`_ * Edenberg HJ et al. "Genome-wide association study of alcohol dependence implicates a region on chromosome 11." Alcohol Clin Exp Res. 2010 May;34(5):840-52. `PMID 20201924`_ * Pezzolesi MG et al. "Genome-wide association scan for diabetic nephropathy susceptibility genes in type 1 diabetes." Diabetes. 2009 Jun;58(6):1403-10. `PMID 19252134`_ * Ouyang J et al. "Direct binding of CoREST1 to SUMO-2/3 contributes to gene-specific repression by the LSD1/CoREST1/HDAC complex." Mol Cell. 2009 Apr 24;34(2):145-54. `PMID 19394292`_ * Linkermann A et al. "Identification of interaction partners for individual SH3 domains of Fas ligand associated members of the PCH protein family in T lymphocytes." Biochim Biophys Acta. 2009 Feb;1794(2):168-76. `PMID 19041431`_ .. _PMID 21139048: http://www.ncbi.nlm.nih.gov/pubmed/21139048 .. _PMID 20201924: http://www.ncbi.nlm.nih.gov/pubmed/20201924 .. _PMID 19394292: http://www.ncbi.nlm.nih.gov/pubmed/19394292 .. _PMID 20460425: http://www.ncbi.nlm.nih.gov/pubmed/20460425 .. _PMID 21963094: http://www.ncbi.nlm.nih.gov/pubmed/21963094 .. _PMID 19252134: http://www.ncbi.nlm.nih.gov/pubmed/19252134 .. _PMID 20306291: http://www.ncbi.nlm.nih.gov/pubmed/20306291 .. _PMID 20834067: http://www.ncbi.nlm.nih.gov/pubmed/20834067 .. _PMID 21906983: http://www.ncbi.nlm.nih.gov/pubmed/21906983 .. _PMID 19041431: http://www.ncbi.nlm.nih.gov/pubmed/19041431 *Top Pubmed articles linked to gene CARS matching any search term:* * Ferro F et al. "Long-chain acylcarnitines regulate the HERG channel." PLoS One. 2012;7(7):e41686. `PMID 22848566`_ * Giraldo MA et al. "Land-use and land-cover assessment for the study of lifestyle change in a rural Mexican community: The Maycoba Project." Int J Health Geogr. 2012 Jul 9;11(1):27. `PMID 22776075`_ * Jarrett J et al. "Effect of increasing active travel in urban England and Wales on costs to the National Health Service." Lancet. 2012 Jun 9;379(9832):2198-205. `PMID 22682466`_ * Chumnanpuen P et al. "Lipid biosynthesis monitored at the single-cell level in Saccharomyces cerevisiae." Biotechnol J. 2012 May;7(5):594-601. `PMID 22442011`_ * Mauroy C et al. "Giant lipid vesicles under electric field pulses assessed by non invasive imaging." Bioelectrochemistry. 2012 Apr 5;. `PMID 22560131`_ * Hu C et al. "CPVL/CHN2 genetic variant is associated with diabetic retinopathy in Chinese type 2 diabetic patients." Diabetes. 2011 Nov;60(11):3085-9. `PMID 21911749`_ * Lee J et al. "Getting into the healthcare game. Companies outside of healthcare are pursuing innovative ways to enter the market." Mod Healthc. 2011 Sep 19;41(38):31-2. `PMID 21995141`_ * Owen N et al. "Adults' sedentary behavior determinants and interventions." Am J Prev Med. 2011 Aug;41(2):189-96. `PMID 21767727`_ * Jang TW et al. "The association between impaired fasting glucose and noise-induced hearing loss." J Occup Health. 2011;53(4):274-9. `PMID 21670562`_ * Dassau E et al. "Closing the loop." Int J Clin Pract Suppl. 2011 Feb;(170):20-5. `PMID 21323809`_ * Maeda S et al. "Replication study for the association between four Loci identified by a genome-wide association study on European American subjects with type 1 diabetes and susceptibility to diabetic nephropathy in Japanese subjects with type 2 diabetes." Diabetes. 2010 Aug;59(8):2075-9. `PMID 20460425`_ * Pezzolesi MG et al. "Genome-wide association scan for diabetic nephropathy susceptibility genes in type 1 diabetes." Diabetes. 2009 Jun;58(6):1403-10. `PMID 19252134`_ .. _PMID 21767727: http://www.ncbi.nlm.nih.gov/pubmed/21767727 .. _PMID 22560131: http://www.ncbi.nlm.nih.gov/pubmed/22560131 .. _PMID 22848566: http://www.ncbi.nlm.nih.gov/pubmed/22848566 .. _PMID 21323809: http://www.ncbi.nlm.nih.gov/pubmed/21323809 .. _PMID 21995141: http://www.ncbi.nlm.nih.gov/pubmed/21995141 .. _PMID 20460425: http://www.ncbi.nlm.nih.gov/pubmed/20460425 .. _PMID 22682466: http://www.ncbi.nlm.nih.gov/pubmed/22682466 .. _PMID 19252134: http://www.ncbi.nlm.nih.gov/pubmed/19252134 .. _PMID 22776075: http://www.ncbi.nlm.nih.gov/pubmed/22776075 .. _PMID 21911749: http://www.ncbi.nlm.nih.gov/pubmed/21911749 .. _PMID 22442011: http://www.ncbi.nlm.nih.gov/pubmed/22442011 .. _PMID 21670562: http://www.ncbi.nlm.nih.gov/pubmed/21670562