.. _CDC123: CDC123 ^^^^^^ .. contents:: :local: General Information ******************* :Full gene name: cell division cycle 123 homolog (S. cerevisiae) :Entrez Gene ID: 8872 :Location: 10p13 :Synonyms: D123, C10orf7 :Type: protein-coding User SNPs ********* SNPs given by the user that are near or inside this gene: +------------+---------------+------------+ | SNP | Distance (bp) | Direction | +============+===============+============+ | rs12779790 | 35421 | downstream | +------------+---------------+------------+ .. _CDC123 Gene summary: NCBI Summary ************ None available. .. _CDC123 OMIM Text: OMIM **** No OMIM data available for this gene. .. _CDC123 Phenotype: NCBI Phenotypes *************** * Identification of new genetic risk variants for type 2 \ ``diabetes``\ . * NHGRI GWA Catalog * Genome-wide association and large-scale follow up identifies 16 new loci influencing lung function. * Meta-analysis of genome-wide association data and large-scale replication identifies additional susceptibility loci for type 2 \ ``diabetes``\ . .. _CDC123 GO Term: Gene Ontology ************* * G1 phase of mitotic cell cycle * cell cycle arrest * cell division * cytoplasm * regulation of mitotic cell cycle * positive regulation of cell proliferation .. _CDC123 Pathway: KEGG Pathways ************* No pathways found linked to this gene. .. _CDC123 GeneRIF: GeneRIFs ******** * Observational study of gene-disease association, gene-gene interaction, and gene-environment interaction. (HuGE Navigator) [`PMID 20889853`_] * Affinity Capture-MS [`PMID 21987572`_] * Observational study of gene-disease association. (HuGE Navigator) [`PMID 20816152`_] * Observational study and meta-analysis of gene-disease association. (HuGE Navigator) [`PMID 20927120`_] * Observational study of gene-disease association, gene-gene interaction, gene-environment interaction, and genetic testing. (HuGE Navigator) [`PMID 20075150`_] * Meta-analysis and genome-wide association study of gene-disease association. (HuGE Navigator) [`PMID 18372903`_] * Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator) [`PMID 20379614`_] * A significant association of rs10906115 in CDC123/CAMK1D and rs1359790 near SPRY2 was identified with type 2 \ ``diabetes``\ in a Japanese population. [`PMID 21909839`_] * Dosage Rescue [`PMID 15319434`_] * Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator) [`PMID 20571754`_] * Meta-analysis and HuGE review of gene-disease association. (HuGE Navigator) [`PMID 19602701`_] * Observational study of gene-disease association, gene-gene interaction, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator) [`PMID 20879858`_] .. _PMID 20889853: http://www.ncbi.nlm.nih.gov/pubmed/20889853 .. _PMID 21987572: http://www.ncbi.nlm.nih.gov/pubmed/21987572 .. _PMID 20816152: http://www.ncbi.nlm.nih.gov/pubmed/20816152 .. _PMID 20927120: http://www.ncbi.nlm.nih.gov/pubmed/20927120 .. _PMID 20075150: http://www.ncbi.nlm.nih.gov/pubmed/20075150 .. _PMID 18372903: http://www.ncbi.nlm.nih.gov/pubmed/18372903 .. _PMID 20379614: http://www.ncbi.nlm.nih.gov/pubmed/20379614 .. _PMID 21909839: http://www.ncbi.nlm.nih.gov/pubmed/21909839 .. _PMID 15319434: http://www.ncbi.nlm.nih.gov/pubmed/15319434 .. _PMID 20571754: http://www.ncbi.nlm.nih.gov/pubmed/20571754 .. _PMID 19602701: http://www.ncbi.nlm.nih.gov/pubmed/19602701 .. _PMID 20879858: http://www.ncbi.nlm.nih.gov/pubmed/20879858 .. _CDC123 Pubmed: PubMed Articles *************** *Recent articles:* * Lee KA et al. "Ubiquitin ligase substrate identification through quantitative proteomics at both the protein and peptide levels." J Biol Chem. 2011 Dec 2;286(48):41530-8. `PMID 21987572`_ * Imamura M et al. "Genetic variants at CDC123/CAMK1D and SPRY2 are associated with susceptibility to type 2 diabetes in the Japanese population." Diabetologia. 2011 Dec;54(12):3071-7. `PMID 21909839`_ * Kim W et al. "Systematic and quantitative assessment of the ubiquitin-modified proteome." Mol Cell. 2011 Oct 21;44(2):325-40. `PMID 21906983`_ * Wagner SA et al. "A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles." Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. `PMID 21890473`_ * Soler Artigas M et al. "Genome-wide association and large-scale follow up identifies 16 new loci influencing lung function." Nat Genet. 2011 Sep 25;43(11):1082-90. `PMID 21946350`_ * Danielsen JM et al. "Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level." Mol Cell Proteomics. 2011 Mar;10(3):M110.003590. `PMID 21139048`_ * de Miguel-Yanes JM et al. "Genetic risk reclassification for type 2 diabetes by age below or above 50 years using 40 type 2 diabetes risk single nucleotide polymorphisms." Diabetes Care. 2011 Jan;34(1):121-5. `PMID 20889853`_ * Zhou DZ et al. "Variations in/nearby genes coding for JAZF1, TSPAN8/LGR5 and HHEX-IDE and risk of type 2 diabetes in Han Chinese." J Hum Genet. 2010 Dec;55(12):810-5. `PMID 20927120`_ * Rotger M et al. "Impact of single nucleotide polymorphisms and of clinical risk factors on new‐onset diabetes mellitus in HIV‐infected individuals." Clin Infect Dis. 2010 Nov 1;51(9):1090-8. `PMID 20879858`_ * Shu XO et al. "Identification of new genetic risk variants for type 2 diabetes." PLoS Genet. 2010 Sep 16;6(9). `PMID 20862305`_ .. _PMID 21890473: http://www.ncbi.nlm.nih.gov/pubmed/21890473 .. _PMID 20889853: http://www.ncbi.nlm.nih.gov/pubmed/20889853 .. _PMID 21139048: http://www.ncbi.nlm.nih.gov/pubmed/21139048 .. _PMID 20927120: http://www.ncbi.nlm.nih.gov/pubmed/20927120 .. _PMID 21987572: http://www.ncbi.nlm.nih.gov/pubmed/21987572 .. _PMID 20862305: http://www.ncbi.nlm.nih.gov/pubmed/20862305 .. _PMID 21946350: http://www.ncbi.nlm.nih.gov/pubmed/21946350 .. _PMID 21906983: http://www.ncbi.nlm.nih.gov/pubmed/21906983 .. _PMID 20879858: http://www.ncbi.nlm.nih.gov/pubmed/20879858 .. _PMID 21909839: http://www.ncbi.nlm.nih.gov/pubmed/21909839 *Top Pubmed articles linked to gene CDC123 matching any search term:* * Imamura M et al. "Genetic variants at CDC123/CAMK1D and SPRY2 are associated with susceptibility to type 2 diabetes in the Japanese population." Diabetologia. 2011 Dec;54(12):3071-7. `PMID 21909839`_ * Vangipurapu J et al. "Association of indices of liver and adipocyte insulin resistance with 19 confirmed susceptibility loci for type 2 diabetes in 6,733 non-diabetic Finnish men." Diabetologia. 2011 Mar;54(3):563-71. `PMID 21153532`_ * de Miguel-Yanes JM et al. "Genetic risk reclassification for type 2 diabetes by age below or above 50 years using 40 type 2 diabetes risk single nucleotide polymorphisms." Diabetes Care. 2011 Jan;34(1):121-5. `PMID 20889853`_ * Zhou DZ et al. "Variations in/nearby genes coding for JAZF1, TSPAN8/LGR5 and HHEX-IDE and risk of type 2 diabetes in Han Chinese." J Hum Genet. 2010 Dec;55(12):810-5. `PMID 20927120`_ * Stuebe AM et al. "Obesity and diabetes genetic variants associated with gestational weight gain." Am J Obstet Gynecol. 2010 Sep;203(3):283.e1-17. `PMID 20816152`_ * Morgan AR et al. "Obesity and diabetes genes are associated with being born small for gestational age: results from the Auckland Birthweight Collaborative study." BMC Med Genet. 2010 Aug 16;11:125. `PMID 20712903`_ * Zhao J et al. "Examination of all type 2 diabetes GWAS loci reveals HHEX-IDE as a locus influencing pediatric BMI." Diabetes. 2010 Mar;59(3):751-5. `PMID 19933996`_ * Wen J et al. "Investigation of type 2 diabetes risk alleles support CDKN2A/B, CDKAL1, and TCF7L2 as susceptibility genes in a Han Chinese cohort." PLoS One. 2010 Feb 10;5(2):e9153. `PMID 20161779`_ * Talmud PJ et al. "Utility of genetic and non-genetic risk factors in prediction of type 2 diabetes: Whitehall II prospective cohort study." BMJ. 2010 Jan 14;340:b4838. `PMID 20075150`_ * Schleinitz D et al. "Lack of significant effects of the type 2 diabetes susceptibility loci JAZF1, CDC123/CAMK1D, NOTCH2, ADAMTS9, THADA, and TSPAN8/LGR5 on diabetes and quantitative metabolic traits." Horm Metab Res. 2010 Jan;42(1):14-22. `PMID 19670153`_ * Simonis-Bik AM et al. "Gene variants in the novel type 2 diabetes loci CDC123/CAMK1D, THADA, ADAMTS9, BCL11A, and MTNR1B affect different aspects of pancreatic beta-cell function." Diabetes. 2010 Jan;59(1):293-301. `PMID 19833888`_ * Lango Allen H et al. "Polygenic risk variants for type 2 diabetes susceptibility modify age at diagnosis in monogenic HNF1A diabetes." Diabetes. 2010 Jan;59(1):266-71. `PMID 19794065`_ * Boesgaard TW et al. "Variant near ADAMTS9 known to associate with type 2 diabetes is related to insulin resistance in offspring of type 2 diabetes patients--EUGENE2 study." PLoS One. 2009 Sep 30;4(9):e7236. `PMID 19789630`_ * Kang ES et al. "Association of common type 2 diabetes risk gene variants and posttransplantation diabetes mellitus in renal allograft recipients in Korea." Transplantation. 2009 Sep 15;88(5):693-8. `PMID 19741467`_ * Stancáková A et al. "Association of 18 confirmed susceptibility loci for type 2 diabetes with indices of insulin release, proinsulin conversion, and insulin sensitivity in 5,327 nondiabetic Finnish men." Diabetes. 2009 Sep;58(9):2129-36. `PMID 19502414`_ * Omori S et al. "Replication study for the association of new meta-analysis-derived risk loci with susceptibility to type 2 diabetes in 6,244 Japanese individuals." Diabetologia. 2009 Aug;52(8):1554-60. `PMID 19455301`_ .. _PMID 19502414: http://www.ncbi.nlm.nih.gov/pubmed/19502414 .. _PMID 20889853: http://www.ncbi.nlm.nih.gov/pubmed/20889853 .. _PMID 20712903: http://www.ncbi.nlm.nih.gov/pubmed/20712903 .. _PMID 19933996: http://www.ncbi.nlm.nih.gov/pubmed/19933996 .. _PMID 20816152: http://www.ncbi.nlm.nih.gov/pubmed/20816152 .. _PMID 20927120: http://www.ncbi.nlm.nih.gov/pubmed/20927120 .. _PMID 20075150: http://www.ncbi.nlm.nih.gov/pubmed/20075150 .. _PMID 19670153: http://www.ncbi.nlm.nih.gov/pubmed/19670153 .. _PMID 19833888: http://www.ncbi.nlm.nih.gov/pubmed/19833888 .. _PMID 19794065: http://www.ncbi.nlm.nih.gov/pubmed/19794065 .. _PMID 21909839: http://www.ncbi.nlm.nih.gov/pubmed/21909839 .. _PMID 19455301: http://www.ncbi.nlm.nih.gov/pubmed/19455301 .. _PMID 21153532: http://www.ncbi.nlm.nih.gov/pubmed/21153532 .. _PMID 20161779: http://www.ncbi.nlm.nih.gov/pubmed/20161779 .. _PMID 19741467: http://www.ncbi.nlm.nih.gov/pubmed/19741467 .. _PMID 19789630: http://www.ncbi.nlm.nih.gov/pubmed/19789630