.. _CREB5: CREB5 ^^^^^ .. contents:: :local: General Information ******************* :Full gene name: cAMP responsive element binding protein 5 :Entrez Gene ID: 9586 :Location: 7p15.1 :Synonyms: CRE-BPA :Type: protein-coding User SNPs ********* SNPs given by the user that are near or inside this gene: +----------+---------------+-----------+ | SNP | Distance (bp) | Direction | +==========+===============+===========+ | rs864745 | 158384 | upstream | +----------+---------------+-----------+ .. _CREB5 Gene summary: NCBI Summary ************ The product of this gene belongs to the CRE (cAMP response element)-binding protein family. Members of this family contain zinc-finger and bZIP DNA-binding domains. The encoded protein specifically binds to CRE as a homodimer or a heterodimer with c-Jun or CRE-BP1, and functions as a CRE-dependent trans-activator. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008] .. _CREB5 OMIM Text: OMIM **** No OMIM data available for this gene. .. _CREB5 Phenotype: NCBI Phenotypes *************** * NHGRI GWA Catalog * Genome-wide meta-analysis for severe diabetic retinopathy. * Molecular genetics of adult ADHD: converging evidence from genome-wide association and extended pedigree linkage studies. .. _CREB5 GO Term: Gene Ontology ************* * protein binding * protein dimerization activity * zinc ion binding * positive regulation of transcription, DNA-dependent * nucleus * sequence-specific DNA binding * sequence-specific DNA binding transcription factor activity * transcription from RNA polymerase II promoter .. _CREB5 Pathway: KEGG Pathways ************* * `Cholinergic synapse `_ * `Prostate cancer `_ * `Huntington's disease `_ * `Amphetamine addiction `_ * `Cocaine addiction `_ * `Vasopressin-regulated water reabsorption `_ * `Dopaminergic synapse `_ * `Alcoholism `_ .. _CREB5 GeneRIF: GeneRIFs ******** * Affinity Capture-MS [`PMID 21890473`_] * Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator) [`PMID 20379614`_] * Reconstituted Complex [`PMID 8440710`_] * Reconstituted Complex [`PMID 8440710`_] * Clinical trial and genome-wide association study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator) [`PMID 18519826`_] * Observational study of gene-disease association. (HuGE Navigator) [`PMID 20080650`_] .. _PMID 21890473: http://www.ncbi.nlm.nih.gov/pubmed/21890473 .. _PMID 20379614: http://www.ncbi.nlm.nih.gov/pubmed/20379614 .. _PMID 8440710: http://www.ncbi.nlm.nih.gov/pubmed/8440710 .. _PMID 18519826: http://www.ncbi.nlm.nih.gov/pubmed/18519826 .. _PMID 20080650: http://www.ncbi.nlm.nih.gov/pubmed/20080650 .. _CREB5 Pubmed: PubMed Articles *************** *Recent articles:* * Wagner SA et al. "A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles." Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. `PMID 21890473`_ * Grassi MA et al. "Genome-wide meta-analysis for severe diabetic retinopathy." Hum Mol Genet. 2011 Jun 15;20(12):2472-81. `PMID 21441570`_ * Reina Ortiz M et al. "Effects of chronic ascariasis and trichuriasis on cytokine production and gene expression in human blood: a cross-sectional study." PLoS Negl Trop Dis. 2011 Jun;5(6):e1157. `PMID 21666788`_ * Rose JE et al. "Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score." Mol Med. 2010 Jul-Aug;16(7-8):247-53. `PMID 20379614`_ * Xu J et al. "Inherited genetic variant predisposes to aggressive but not indolent prostate cancer." Proc Natl Acad Sci U S A. 2010 Feb 2;107(5):2136-40. `PMID 20080650`_ * Trynka G et al. "Coeliac disease-associated risk variants in TNFAIP3 and REL implicate altered NF-kappaB signalling." Gut. 2009 Aug;58(8):1078-83. `PMID 19240061`_ * Lesch KP et al. "Molecular genetics of adult ADHD: converging evidence from genome-wide association and extended pedigree linkage studies." J Neural Transm. 2008 Nov;115(11):1573-85. `PMID 18839057`_ * Uhl GR et al. "Molecular genetics of successful smoking cessation: convergent genome-wide association study results." Arch Gen Psychiatry. 2008 Jun;65(6):683-93. `PMID 18519826`_ * Gerhard DS et al. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." Genome Res. 2004 Oct;14(10B):2121-7. `PMID 15489334`_ * Ota T et al. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat Genet. 2004 Jan;36(1):40-5. `PMID 14702039`_ .. _PMID 21890473: http://www.ncbi.nlm.nih.gov/pubmed/21890473 .. _PMID 18519826: http://www.ncbi.nlm.nih.gov/pubmed/18519826 .. _PMID 18839057: http://www.ncbi.nlm.nih.gov/pubmed/18839057 .. _PMID 14702039: http://www.ncbi.nlm.nih.gov/pubmed/14702039 .. _PMID 19240061: http://www.ncbi.nlm.nih.gov/pubmed/19240061 .. _PMID 20379614: http://www.ncbi.nlm.nih.gov/pubmed/20379614 .. _PMID 15489334: http://www.ncbi.nlm.nih.gov/pubmed/15489334 .. _PMID 21441570: http://www.ncbi.nlm.nih.gov/pubmed/21441570 .. _PMID 21666788: http://www.ncbi.nlm.nih.gov/pubmed/21666788 .. _PMID 20080650: http://www.ncbi.nlm.nih.gov/pubmed/20080650 *Top Pubmed articles linked to gene CREB5 matching any search term:* * Grassi MA et al. "Genome-wide meta-analysis for severe diabetic retinopathy." Hum Mol Genet. 2011 Jun 15;20(12):2472-81. `PMID 21441570`_ * Herrmann J et al. "Isomer-specific effects of CLA on gene expression in human adipose tissue depending on PPARgamma2 P12A polymorphism: a double blind, randomized, controlled cross-over study." Lipids Health Dis. 2009 Aug 18;8:35. `PMID 19689798`_ .. _PMID 21441570: http://www.ncbi.nlm.nih.gov/pubmed/21441570 .. _PMID 19689798: http://www.ncbi.nlm.nih.gov/pubmed/19689798