.. _DUSP14: DUSP14 ^^^^^^ .. contents:: :local: General Information ******************* :Full gene name: dual specificity phosphatase 14 :Entrez Gene ID: 11072 :Location: 17q12 :Synonyms: MKP-L, MKP6 :Type: protein-coding User SNPs ********* SNPs given by the user that are near or inside this gene: +----------+---------------+------------+ | SNP | Distance (bp) | Direction | +==========+===============+============+ | rs757210 | 222927 | downstream | +----------+---------------+------------+ .. _DUSP14 Gene summary: NCBI Summary ************ Dual-specificity phosphatases (DUSPs) constitute a large heterogeneous subgroup of the type I cysteine-based protein-tyrosine phosphatase superfamily. DUSPs are characterized by their ability to dephosphorylate both tyrosine and serine/threonine residues. They have been implicated as major modulators of critical signaling pathways. DUSP14 contains the consensus DUSP C-terminal catalytic domain but lacks the N-terminal CH2 domain found in the MKP (mitogen-activated protein kinase phosphatase) class of DUSPs (see MIM 600714) (summary by Patterson et al., 2009 [PubMed 19228121]).[supplied by OMIM, Dec 2009] .. _OMIM ID 606618 : http://omim.org/entry/606618 .. _DUSP14 OMIM Text: OMIM **** :OMIM ID: `OMIM ID 606618 `_ .. _DUSP14 Phenotype: NCBI Phenotypes *************** * NHGRI GWA Catalog * Genome-wide association analyses identifies a susceptibility locus for tuberculosis on chromosome 18q11.2. .. _DUSP14 GO Term: Gene Ontology ************* * MAP kinase tyrosine/serine/threonine phosphatase activity * protein tyrosine phosphatase activity * peptidyl-tyrosine dephosphorylation * protein tyrosine/serine/threonine phosphatase activity .. _DUSP14 Pathway: KEGG Pathways ************* * `MAPK signaling pathway `_ .. _DUSP14 GeneRIF: GeneRIFs ******** * Affinity Capture-Western; Reconstituted Complex; Two-hybrid [`PMID 11123293`_] * DUSP14 may be a susceptibility gene for pulmonary tuberculosis. [`PMID 22233810`_] * Activation of ATM by radiation down-regulates phospho-ERK1/2 and its downstream signaling via increased expression of mitogen-activated protein kinase phosphatase MKP-1. [`PMID 17178844`_] * Reconstituted Complex [`PMID 21800051`_] * The overproduction, purification and crystal structure at 1.88 A resolution of human dual-specificity phosphatase 14, DUSP14 (MKP6), are reported. [`PMID 19770498`_] * The binding of Lipomannan to TLR2 triggers MAPK activation, followed by an up-regulation of MKP-1 expression, which in turn may act as a negative regulator of MAPK activation. [`PMID 18201568`_] * Affinity Capture-MS [`PMID 21906983`_] .. _PMID 11123293: http://www.ncbi.nlm.nih.gov/pubmed/11123293 .. _PMID 22233810: http://www.ncbi.nlm.nih.gov/pubmed/22233810 .. _PMID 17178844: http://www.ncbi.nlm.nih.gov/pubmed/17178844 .. _PMID 21800051: http://www.ncbi.nlm.nih.gov/pubmed/21800051 .. _PMID 19770498: http://www.ncbi.nlm.nih.gov/pubmed/19770498 .. _PMID 18201568: http://www.ncbi.nlm.nih.gov/pubmed/18201568 .. _PMID 21906983: http://www.ncbi.nlm.nih.gov/pubmed/21906983 .. _DUSP14 Pubmed: PubMed Articles *************** *Recent articles:* * Barreiro LB et al. "Deciphering the genetic architecture of variation in the immune response to Mycobacterium tuberculosis infection." Proc Natl Acad Sci U S A. 2012 Jan 24;109(4):1204-9. `PMID 22233810`_ * Fang Y et al. "The interaction between ubiquitin C-terminal hydrolase 37 and glucose-regulated protein 78 in hepatocellular carcinoma." Mol Cell Biochem. 2012 Jan;359(1-2):59-66. `PMID 21800051`_ * Kim W et al. "Systematic and quantitative assessment of the ubiquitin-modified proteome." Mol Cell. 2011 Oct 21;44(2):325-40. `PMID 21906983`_ * Wagner SA et al. "A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles." Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. `PMID 21890473`_ * Danielsen JM et al. "Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level." Mol Cell Proteomics. 2011 Mar;10(3):M110.003590. `PMID 21139048`_ * Thye T et al. "Genome-wide association analyses identifies a susceptibility locus for tuberculosis on chromosome 18q11.2." Nat Genet. 2010 Sep;42(9):739-41. `PMID 20694014`_ * Lountos GT et al. "Overproduction, purification and structure determination of human dual-specificity phosphatase 14." Acta Crystallogr D Biol Crystallogr. 2009 Oct;65(Pt 10):1013-20. `PMID 19770498`_ * Patterson KI et al. "Dual-specificity phosphatases: critical regulators with diverse cellular targets." Biochem J. 2009 Mar 15;418(3):475-89. `PMID 19228121`_ * Elass E et al. "Mycobacterial lipomannan induces MAP kinase phosphatase-1 expression in macrophages." FEBS Lett. 2008 Feb 6;582(3):445-50. `PMID 18201568`_ * Nyati MK et al. "Ataxia telangiectasia mutated down-regulates phospho-extracellular signal-regulated kinase 1/2 via activation of MKP-1 in response to radiation." Cancer Res. 2006 Dec 15;66(24):11554-9. `PMID 17178844`_ .. _PMID 21890473: http://www.ncbi.nlm.nih.gov/pubmed/21890473 .. _PMID 17178844: http://www.ncbi.nlm.nih.gov/pubmed/17178844 .. _PMID 22233810: http://www.ncbi.nlm.nih.gov/pubmed/22233810 .. _PMID 21139048: http://www.ncbi.nlm.nih.gov/pubmed/21139048 .. _PMID 21800051: http://www.ncbi.nlm.nih.gov/pubmed/21800051 .. _PMID 19770498: http://www.ncbi.nlm.nih.gov/pubmed/19770498 .. _PMID 19228121: http://www.ncbi.nlm.nih.gov/pubmed/19228121 .. _PMID 18201568: http://www.ncbi.nlm.nih.gov/pubmed/18201568 .. _PMID 20694014: http://www.ncbi.nlm.nih.gov/pubmed/20694014 .. _PMID 21906983: http://www.ncbi.nlm.nih.gov/pubmed/21906983 *Top Pubmed articles linked to gene DUSP14 matching any search term:* * Fang Y et al. "The interaction between ubiquitin C-terminal hydrolase 37 and glucose-regulated protein 78 in hepatocellular carcinoma." Mol Cell Biochem. 2012 Jan;359(1-2):59-66. `PMID 21800051`_ * Hendrix NW et al. "Prenatally diagnosed 17q12 microdeletion syndrome with a novel association with congenital diaphragmatic hernia." Fetal Diagn Ther. 2012;31(2):129-33. `PMID 22178801`_ * Klinger S et al. "Increasing GLP-1-induced beta-cell proliferation by silencing the negative regulators of signaling cAMP response element modulator-alpha and DUSP14." Diabetes. 2008 Mar;57(3):584-93. `PMID 18025410`_ .. _PMID 21800051: http://www.ncbi.nlm.nih.gov/pubmed/21800051 .. _PMID 18025410: http://www.ncbi.nlm.nih.gov/pubmed/18025410 .. _PMID 22178801: http://www.ncbi.nlm.nih.gov/pubmed/22178801