.. _ESRP1:

ESRP1
^^^^^

.. contents::
   :local:

General Information
*******************

:Full gene name: epithelial splicing regulatory protein 1
:Entrez Gene ID: 54845
:Location: 8q22.1
:Synonyms: RBM35A, RMB35A
:Type: protein-coding

User SNPs
*********

SNPs given by the user that are near or inside this gene: 

+----------+---------------+------------+
|   SNP    | Distance (bp) | Direction  |
+==========+===============+============+
| rs896854 |     240817    | downstream |
+----------+---------------+------------+

.. _ESRP1 Gene summary:

NCBI Summary
************

ESPR1 is an epithelial cell-type-specific splicing regulator (Warzecha et al., 2009 [PubMed 19285943]).[supplied by OMIM, Aug 2009]

.. _OMIM ID 612959
                        : http://omim.org/entry/612959
                        

.. _ESRP1 OMIM Text:

OMIM
****

:OMIM ID: `OMIM ID 612959
                        `_


.. _ESRP1 Phenotype:

NCBI Phenotypes
***************

No phenotypes found linked to this gene.

.. _ESRP1 GO Term:

Gene Ontology
*************

* nucleolus
* regulation of RNA splicing
* RNA splicing
* mRNA processing
* nucleus
* mRNA binding
* nucleotide binding
* plasma membrane

.. _ESRP1 Pathway:

KEGG Pathways
*************

No pathways found linked to this gene.

.. _ESRP1 GeneRIF:

GeneRIFs
********

* results further establish ESRP1 and ESRP2 as global regulators of an epithelial splicing regulatory network. [`PMID 19829082`_]
* The FLJ20171 gene was shown to effectively separate these two chromophobe renal cell carcinoma (RCC) and benign oncocytoma groups by quantitative reverse transcription-PCR using fresh tissue samples, with similar trends seen on formalin-fixed tissues. [`PMID 17145811`_]
* The functional significance of EMT-associated alternative splicing was tested by expression of the epithelial-specific splicing factor ESRP1 [`PMID 21876675`_]
* ESRP1 coordinates a complex alternative splicing network that adds an important post-transcriptional layer to the changes in gene expression that underlie epithelial-mesenchymal transitions during development and disease. [`PMID 20711167`_]
* functions of the ESRP1 in an epithelial posttranscriptional gene expression program. [`PMID 22354987`_]
* ESRP1 and ESRP2 are epithelial cell-type-specific regulators of FGFR2 splicing. [`PMID 19285943`_]
* Affinity Capture-MS [`PMID 21906983`_]
* Results demonstrate that RBM35A functions as a tumor suppressor in colon cancer cells, and suggest that RBM35A is involved in posttranscriptional regulation of a number of genes by exerting a differential effect on protein translation via 5'UTRs of mRNAs. [`PMID 19177006`_]

.. _PMID 19829082: http://www.ncbi.nlm.nih.gov/pubmed/19829082
.. _PMID 17145811: http://www.ncbi.nlm.nih.gov/pubmed/17145811
.. _PMID 21876675: http://www.ncbi.nlm.nih.gov/pubmed/21876675
.. _PMID 20711167: http://www.ncbi.nlm.nih.gov/pubmed/20711167
.. _PMID 22354987: http://www.ncbi.nlm.nih.gov/pubmed/22354987
.. _PMID 19285943: http://www.ncbi.nlm.nih.gov/pubmed/19285943
.. _PMID 21906983: http://www.ncbi.nlm.nih.gov/pubmed/21906983
.. _PMID 19177006: http://www.ncbi.nlm.nih.gov/pubmed/19177006

.. _ESRP1 Pubmed:

PubMed Articles
***************

*Recent articles:*

* Dittmar KA et al. "Genome-wide determination of a broad ESRP-regulated posttranscriptional network by high-throughput sequencing." Mol Cell Biol. 2012 Apr;32(8):1468-82. `PMID 22354987`_
* Kim W et al. "Systematic and quantitative assessment of the ubiquitin-modified proteome." Mol Cell. 2011 Oct 21;44(2):325-40. `PMID 21906983`_
* Shapiro IM et al. "An EMT-driven alternative splicing program occurs in human breast cancer and modulates cellular phenotype." PLoS Genet. 2011 Aug;7(8):e1002218. `PMID 21876675`_
* Warzecha CC et al. "An ESRP-regulated splicing programme is abrogated during the epithelial-mesenchymal transition." EMBO J. 2010 Oct 6;29(19):3286-300. `PMID 20711167`_
* Warzecha CC et al. "The epithelial splicing factors ESRP1 and ESRP2 positively and negatively regulate diverse types of alternative splicing events." RNA Biol. 2009 Nov-Dec;6(5):546-62. `PMID 19829082`_
* Warzecha CC et al. "ESRP1 and ESRP2 are epithelial cell-type-specific regulators of FGFR2 splicing." Mol Cell. 2009 Mar 13;33(5):591-601. `PMID 19285943`_
* Leontieva OV et al. "RNA-binding motif protein 35A is a novel tumor suppressor for colorectal cancer." Cell Cycle. 2009 Feb 1;8(3):490-7. `PMID 19177006`_
* Barbe L et al. "Toward a confocal subcellular atlas of the human proteome." Mol Cell Proteomics. 2008 Mar;7(3):499-508. `PMID 18029348`_
* Rohan S et al. "Gene expression profiling separates chromophobe renal cell carcinoma from oncocytoma and identifies vesicular transport and cell junction proteins as differentially expressed genes." Clin Cancer Res. 2006 Dec 1;12(23):6937-45. `PMID 17145811`_
* Gerhard DS et al. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." Genome Res. 2004 Oct;14(10B):2121-7. `PMID 15489334`_

.. _PMID 19829082: http://www.ncbi.nlm.nih.gov/pubmed/19829082
.. _PMID 17145811: http://www.ncbi.nlm.nih.gov/pubmed/17145811
.. _PMID 21876675: http://www.ncbi.nlm.nih.gov/pubmed/21876675
.. _PMID 20711167: http://www.ncbi.nlm.nih.gov/pubmed/20711167
.. _PMID 22354987: http://www.ncbi.nlm.nih.gov/pubmed/22354987
.. _PMID 19285943: http://www.ncbi.nlm.nih.gov/pubmed/19285943
.. _PMID 18029348: http://www.ncbi.nlm.nih.gov/pubmed/18029348
.. _PMID 21906983: http://www.ncbi.nlm.nih.gov/pubmed/21906983
.. _PMID 19177006: http://www.ncbi.nlm.nih.gov/pubmed/19177006
.. _PMID 15489334: http://www.ncbi.nlm.nih.gov/pubmed/15489334