.. _ETV5: ETV5 ^^^^ .. contents:: :local: General Information ******************* :Full gene name: ets variant 5 :Entrez Gene ID: 2119 :Location: 3q28 :Synonyms: ERM :Type: protein-coding User SNPs ********* SNPs given by the user that are near or inside this gene: +-----------+---------------+------------+ | SNP | Distance (bp) | Direction | +===========+===============+============+ | rs1470579 | 235026 | downstream | +-----------+---------------+------------+ .. _ETV5 Gene summary: NCBI Summary ************ None available. .. _OMIM ID 601600 : http://omim.org/entry/601600 .. _ETV5 OMIM Text: OMIM **** :OMIM ID: `OMIM ID 601600 `_ .. _ETV5 Phenotype: NCBI Phenotypes *************** * Thirty new loci for age at menarche identified by a meta-analysis of genome-wide association studies. * Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index. * NHGRI GWA Catalog * Genome-wide association yields new sequence variants at seven loci that associate with measures of obesity. .. _ETV5 GO Term: Gene Ontology ************* * transcription regulatory region DNA binding * DNA binding * sequence-specific DNA binding transcription factor activity * positive regulation of transcription, DNA-dependent * cellular response to oxidative stress * sequence-specific DNA binding * regulation of transcription, DNA-dependent * regulation of branching involved in mammary gland duct morphogenesis * nucleus .. _ETV5 Pathway: KEGG Pathways ************* * `Transcriptional misregulation in cancer `_ .. _ETV5 GeneRIF: GeneRIFs ******** * Affinity Capture-Western [`PMID 20062082`_] * Pea3 and Erm, but not Er81, play an important role in the progression of esophageal squamous cell carcinoma [`PMID 21689625`_] * ERM has a role in progression of breast cancer [`PMID 15534105`_] * Reconstituted Complex [`PMID 8798622`_] * functional role for the ERMs (ezrin/radixin/moesin) as adaptor molecules in the interactions of adhesion receptors and intracellular tyrosine kinases [`PMID 12387735`_] * analysis of NHERF recognition by ERM proteins [`PMID 16615918`_] * CD44-mediated hyaluronan binding in myeloid cells is regulated by phosphorylated ERM and the actin cytoskeleton. [`PMID 15652352`_] * Upregulation of ETV5 induced the expression of cell adhesion molecules and enhanced cell survival in a spheroid model. [`PMID 21520040`_] * ERM is subject to SUMO modification and this post-translational modification causes inhibition of transcription-enhancing activity [`PMID 15857832`_] * results indicate concurrent mechanisms in expression of MMP-2 and -9, RUNX1/AML1 and ETV5/ERM, and several basement membrane components, which likely associate with the invasive stage of endometrioid endometrial and ovarian endometrioid carcinoma. [`PMID 20970160`_] * ERM/ETV5 up-regulation activates MMP-2 and thus has a role during myometrial infiltration in endometrial cancer [`PMID 17638886`_] * A TMPRSS2:ETV5 gene fusion was identified in prostate cancer. [`PMID 18172298`_] * Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator) [`PMID 20571754`_] * Observational study of gene-disease association. (HuGE Navigator) [`PMID 20816195`_] * Testing various shorter fragments of ERM as bait indicated that the region essential for binding CHD3/ZFH is within the amino acid region 96-349, which contains the central inhibitory DNA-binding domain (CIDD) of ERM [`PMID 17489097`_] * Erm is involved in SP-C regulation, which results from an interaction with TTF-1 [`PMID 16613858`_] * The erm gene expression is regulated by the conventional PKC (cPKC) pathway. [`PMID 15620692`_] * Affinity Capture-MS; Affinity Capture-Western [`PMID 21572435`_] * Affinity Capture-MS [`PMID 21693764`_] * The flexible nature of transactivation domain may be instrumental for ERM recognition and binding to diverse molecular partners. [`PMID 20647002`_] .. _PMID 20062082: http://www.ncbi.nlm.nih.gov/pubmed/20062082 .. _PMID 21689625: http://www.ncbi.nlm.nih.gov/pubmed/21689625 .. _PMID 15534105: http://www.ncbi.nlm.nih.gov/pubmed/15534105 .. _PMID 8798622: http://www.ncbi.nlm.nih.gov/pubmed/8798622 .. _PMID 12387735: http://www.ncbi.nlm.nih.gov/pubmed/12387735 .. _PMID 16615918: http://www.ncbi.nlm.nih.gov/pubmed/16615918 .. _PMID 15652352: http://www.ncbi.nlm.nih.gov/pubmed/15652352 .. _PMID 21520040: http://www.ncbi.nlm.nih.gov/pubmed/21520040 .. _PMID 15857832: http://www.ncbi.nlm.nih.gov/pubmed/15857832 .. _PMID 20970160: http://www.ncbi.nlm.nih.gov/pubmed/20970160 .. _PMID 17638886: http://www.ncbi.nlm.nih.gov/pubmed/17638886 .. _PMID 18172298: http://www.ncbi.nlm.nih.gov/pubmed/18172298 .. _PMID 20571754: http://www.ncbi.nlm.nih.gov/pubmed/20571754 .. _PMID 20816195: http://www.ncbi.nlm.nih.gov/pubmed/20816195 .. _PMID 17489097: http://www.ncbi.nlm.nih.gov/pubmed/17489097 .. _PMID 16613858: http://www.ncbi.nlm.nih.gov/pubmed/16613858 .. _PMID 15620692: http://www.ncbi.nlm.nih.gov/pubmed/15620692 .. _PMID 21572435: http://www.ncbi.nlm.nih.gov/pubmed/21572435 .. _PMID 21693764: http://www.ncbi.nlm.nih.gov/pubmed/21693764 .. _PMID 20647002: http://www.ncbi.nlm.nih.gov/pubmed/20647002 .. _ETV5 Pubmed: PubMed Articles *************** *Recent articles:* * Llauradó M et al. "ETV5 transcription factor is overexpressed in ovarian cancer and regulates cell adhesion in ovarian cancer cells." Int J Cancer. 2012 Apr 1;130(7):1532-43. `PMID 21520040`_ * Yuen HF et al. "The role of Pea3 group transcription factors in esophageal squamous cell carcinoma." Am J Pathol. 2011 Aug;179(2):992-1003. `PMID 21689625`_ * Tatham MH et al. "Comparative proteomic analysis identifies a role for SUMO in protein quality control." Sci Signal. 2011 Jun 21;4(178):rs4. `PMID 21693764`_ * Vitari AC et al. "COP1 is a tumour suppressor that causes degradation of ETS transcription factors." Nature. 2011 May 15;474(7351):403-6. `PMID 21572435`_ * Planagumà J et al. "Matrix metalloproteinase-2 and matrix metalloproteinase-9 codistribute with transcription factors RUNX1/AML1 and ETV5/ERM at the invasive front of endometrial and ovarian carcinoma." Hum Pathol. 2011 Jan;42(1):57-67. `PMID 20970160`_ * Elks CE et al. "Thirty new loci for age at menarche identified by a meta-analysis of genome-wide association studies." Nat Genet. 2010 Dec;42(12):1077-85. `PMID 21102462`_ * den Hoed M et al. "Genetic susceptibility to obesity and related traits in childhood and adolescence: influence of loci identified by genome-wide association studies." Diabetes. 2010 Nov;59(11):2980-8. `PMID 20724581`_ * Speliotes EK et al. "Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index." Nat Genet. 2010 Nov;42(11):937-48. `PMID 20935630`_ * Melén E et al. "Analyses of shared genetic factors between asthma and obesity in children." J Allergy Clin Immunol. 2010 Sep;126(3):631-7.e1-8. `PMID 20816195`_ * Morgan AR et al. "Obesity and diabetes genes are associated with being born small for gestational age: results from the Auckland Birthweight Collaborative study." BMC Med Genet. 2010 Aug 16;11:125. `PMID 20712903`_ .. _PMID 20712903: http://www.ncbi.nlm.nih.gov/pubmed/20712903 .. _PMID 21689625: http://www.ncbi.nlm.nih.gov/pubmed/21689625 .. _PMID 20816195: http://www.ncbi.nlm.nih.gov/pubmed/20816195 .. _PMID 21520040: http://www.ncbi.nlm.nih.gov/pubmed/21520040 .. _PMID 20724581: http://www.ncbi.nlm.nih.gov/pubmed/20724581 .. _PMID 20970160: http://www.ncbi.nlm.nih.gov/pubmed/20970160 .. _PMID 20935630: http://www.ncbi.nlm.nih.gov/pubmed/20935630 .. _PMID 21102462: http://www.ncbi.nlm.nih.gov/pubmed/21102462 .. _PMID 21693764: http://www.ncbi.nlm.nih.gov/pubmed/21693764 .. _PMID 21572435: http://www.ncbi.nlm.nih.gov/pubmed/21572435 *Top Pubmed articles linked to gene ETV5 matching any search term:* * Boender AJ et al. "Nutritional State Affects the Expression of the Obesity-Associated Genes Etv5, Faim2, Fto, and Negr1." Obesity (Silver Spring). 2012 May 7;. `PMID 22627920`_ * Breitfeld J et al. "Genetics of adiponectin." Biochimie. 2012 Mar 15;. `PMID 22449616`_ * Dorajoo R et al. "Replication of 13 obesity loci among Singaporean Chinese, Malay and Asian-Indian populations." Int J Obes (Lond). 2012 Jan;36(1):159-63. `PMID 21544081`_ * Hotta K et al. "Computed tomography analysis of the association between the SH2B1 rs7498665 single-nucleotide polymorphism and visceral fat area." J Hum Genet. 2011 Oct;56(10):716-9. `PMID 21796141`_ * Sandholt CH et al. "Studies of metabolic phenotypic correlates of 15 obesity associated gene variants." PLoS One. 2011;6(9):e23531. `PMID 21912638`_ * Hotta K et al. "Association of variations in the FTO, SCG3 and MTMR9 genes with metabolic syndrome in a Japanese population." J Hum Genet. 2011 Sep;56(9):647-51. `PMID 21796137`_ * Lopez JP et al. "Glucose-induced ERM protein activation and translocation regulates insulin secretion." Am J Physiol Endocrinol Metab. 2010 Nov;299(5):E772-85. `PMID 20739507`_ * den Hoed M et al. "Genetic susceptibility to obesity and related traits in childhood and adolescence: influence of loci identified by genome-wide association studies." Diabetes. 2010 Nov;59(11):2980-8. `PMID 20724581`_ * Fontaine-Bisson B et al. "Evaluating the discriminative power of multi-trait genetic risk scores for type 2 diabetes in a northern Swedish population." Diabetologia. 2010 Oct;53(10):2155-62. `PMID 20571754`_ * Morgan AR et al. "Obesity and diabetes genes are associated with being born small for gestational age: results from the Auckland Birthweight Collaborative study." BMC Med Genet. 2010 Aug 16;11:125. `PMID 20712903`_ * Ng MC et al. "Implication of genetic variants near NEGR1, SEC16B, TMEM18, ETV5/DGKG, GNPDA2, LIN7C/BDNF, MTCH2, BCDIN3D/FAIM2, SH2B1, FTO, MC4R, and KCTD15 with obesity and type 2 diabetes in 7705 Chinese." J Clin Endocrinol Metab. 2010 May;95(5):2418-25. `PMID 20215397`_ * Cheung CY et al. "Obesity susceptibility genetic variants identified from recent genome-wide association studies: implications in a chinese population." J Clin Endocrinol Metab. 2010 Mar;95(3):1395-403. `PMID 20061430`_ * Thorleifsson G et al. "Genome-wide association yields new sequence variants at seven loci that associate with measures of obesity." Nat Genet. 2009 Jan;41(1):18-24. `PMID 19079260`_ * Kobberup S et al. "ETS-family genes in pancreatic development." Dev Dyn. 2007 Nov;236(11):3100-10. `PMID 17907201`_ .. _PMID 20712903: http://www.ncbi.nlm.nih.gov/pubmed/20712903 .. _PMID 19079260: http://www.ncbi.nlm.nih.gov/pubmed/19079260 .. _PMID 20739507: http://www.ncbi.nlm.nih.gov/pubmed/20739507 .. _PMID 21912638: http://www.ncbi.nlm.nih.gov/pubmed/21912638 .. _PMID 20215397: http://www.ncbi.nlm.nih.gov/pubmed/20215397 .. _PMID 20571754: http://www.ncbi.nlm.nih.gov/pubmed/20571754 .. _PMID 21796137: http://www.ncbi.nlm.nih.gov/pubmed/21796137 .. _PMID 22449616: http://www.ncbi.nlm.nih.gov/pubmed/22449616 .. _PMID 21544081: http://www.ncbi.nlm.nih.gov/pubmed/21544081 .. _PMID 20061430: http://www.ncbi.nlm.nih.gov/pubmed/20061430 .. _PMID 17907201: http://www.ncbi.nlm.nih.gov/pubmed/17907201 .. _PMID 20724581: http://www.ncbi.nlm.nih.gov/pubmed/20724581 .. _PMID 22627920: http://www.ncbi.nlm.nih.gov/pubmed/22627920 .. _PMID 21796141: http://www.ncbi.nlm.nih.gov/pubmed/21796141