.. _HAUS7:

HAUS7
^^^^^

.. contents::
   :local:

General Information
*******************

:Full gene name: HAUS augmin-like complex, subunit 7
:Entrez Gene ID: 55559
:Location: Xq28
:Synonyms: UIP1, UCHL5IP, HSXQ28ORF
:Type: protein-coding

User SNPs
*********

SNPs given by the user that are near or inside this gene: 

+-----------+---------------+-----------+
|    SNP    | Distance (bp) | Direction |
+===========+===============+===========+
| rs3020789 |     156384    |  upstream |
+-----------+---------------+-----------+

.. _HAUS7 Gene summary:

NCBI Summary
************

This gene encodes a protein identified by interaction with ubiquitin C-terminal hydrolase 37, which functions to edit polyubiquitin chains on ubiquitinated substrates. This protein is a subunit of the multisubunit augmin complex, which regulates centrosome and mitotic spindle integrity, and is necessary for the completion of cytokinesis. [provided by RefSeq, Jul 2009]

.. _OMIM ID 300540
                        : http://omim.org/entry/300540
                        

.. _HAUS7 OMIM Text:

OMIM
****

:OMIM ID: `OMIM ID 300540
                        `_


.. _HAUS7 Phenotype:

NCBI Phenotypes
***************

No phenotypes found linked to this gene.

.. _HAUS7 GO Term:

Gene Ontology
*************

* nucleolus
* HAUS complex
* centrosome organization
* cell division
* cytoplasm
* thioesterase binding
* microtubule
* mitosis
* spindle assembly
* spindle
* centrosome
* plasma membrane

.. _HAUS7 Pathway:

KEGG Pathways
*************

No pathways found linked to this gene.

.. _HAUS7 GeneRIF:

GeneRIFs
********

* Dosage Lethality [`PMID 22623531`_]
* Affinity Capture-MS [`PMID 21906983`_]
* Affinity Capture-MS [`PMID 20360068`_]
* Affinity Capture-MS [`PMID 20360068`_]
* Affinity Capture-MS [`PMID 20360068`_]
* Affinity Capture-MS [`PMID 20360068`_]
* Affinity Capture-MS; Affinity Capture-Western [`PMID 19369198`_]
* Affinity Capture-Western; Reconstituted Complex; Two-hybrid [`PMID 11163772`_]

.. _PMID 22623531: http://www.ncbi.nlm.nih.gov/pubmed/22623531
.. _PMID 21906983: http://www.ncbi.nlm.nih.gov/pubmed/21906983
.. _PMID 20360068: http://www.ncbi.nlm.nih.gov/pubmed/20360068
.. _PMID 19369198: http://www.ncbi.nlm.nih.gov/pubmed/19369198
.. _PMID 11163772: http://www.ncbi.nlm.nih.gov/pubmed/11163772

.. _HAUS7 Pubmed:

PubMed Articles
***************

*Recent articles:*

* Toyoshima M et al. "Functional genomics identifies therapeutic targets for MYC-driven cancer." Proc Natl Acad Sci U S A. 2012 Jun 12;109(24):9545-50. `PMID 22623531`_
* Kim W et al. "Systematic and quantitative assessment of the ubiquitin-modified proteome." Mol Cell. 2011 Oct 21;44(2):325-40. `PMID 21906983`_
* Hutchins JR et al. "Systematic analysis of human protein complexes identifies chromosome segregation proteins." Science. 2010 Apr 30;328(5978):593-9. `PMID 20360068`_
* Xin X et al. "Shifted Transversal Design smart-pooling for high coverage interactome mapping." Genome Res. 2009 Jul;19(7):1262-9. `PMID 19447967`_
* Lawo S et al. "HAUS, the 8-subunit human Augmin complex, regulates centrosome and spindle integrity." Curr Biol. 2009 May 26;19(10):816-26. `PMID 19427217`_
* Uehara R et al. "The augmin complex plays a critical role in spindle microtubule generation for mitotic progression and cytokinesis in human cells." Proc Natl Acad Sci U S A. 2009 Apr 28;106(17):6998-7003. `PMID 19369198`_
* Barbe L et al. "Toward a confocal subcellular atlas of the human proteome." Mol Cell Proteomics. 2008 Mar;7(3):499-508. `PMID 18029348`_
* Chen MJ et al. "Biochemical and cellular characteristics of the 3' -> 5' exonuclease TREX2." Nucleic Acids Res. 2007;35(8):2682-94. `PMID 17426129`_
* Hahn Y et al. "Human-specific nonsense mutations identified by genome sequence comparisons." Hum Genet. 2006 Mar;119(1-2):169-78. `PMID 16395595`_
* Mehrle A et al. "The LIFEdb database in 2006." Nucleic Acids Res. 2006 Jan 1;34(Database issue):D415-8. `PMID 16381901`_

.. _PMID 22623531: http://www.ncbi.nlm.nih.gov/pubmed/22623531
.. _PMID 19369198: http://www.ncbi.nlm.nih.gov/pubmed/19369198
.. _PMID 16395595: http://www.ncbi.nlm.nih.gov/pubmed/16395595
.. _PMID 19427217: http://www.ncbi.nlm.nih.gov/pubmed/19427217
.. _PMID 20360068: http://www.ncbi.nlm.nih.gov/pubmed/20360068
.. _PMID 18029348: http://www.ncbi.nlm.nih.gov/pubmed/18029348
.. _PMID 17426129: http://www.ncbi.nlm.nih.gov/pubmed/17426129
.. _PMID 19447967: http://www.ncbi.nlm.nih.gov/pubmed/19447967
.. _PMID 21906983: http://www.ncbi.nlm.nih.gov/pubmed/21906983
.. _PMID 16381901: http://www.ncbi.nlm.nih.gov/pubmed/16381901