.. _HDDC3:

HDDC3
^^^^^

.. contents::
   :local:

General Information
*******************

:Full gene name: HD domain containing 3
:Entrez Gene ID: 374659
:Location: 15q26.1
:Synonyms: MESH1
:Type: protein-coding

User SNPs
*********

SNPs given by the user that are near or inside this gene: 

+-----------+---------------+-----------+
|    SNP    | Distance (bp) | Direction |
+===========+===============+===========+
| rs8042680 |     45563     |  upstream |
+-----------+---------------+-----------+

.. _HDDC3 Gene summary:

NCBI Summary
************

None available.

.. _HDDC3 OMIM Text:

OMIM
****

No OMIM data available for this gene.

.. _HDDC3 Phenotype:

NCBI Phenotypes
***************

No phenotypes found linked to this gene.

.. _HDDC3 GO Term:

Gene Ontology
*************

* guanosine-3',5'-bis(diphosphate) 3'-diphosphatase activity
* metal ion binding
* phosphoric diester hydrolase activity

.. _HDDC3 Pathway:

KEGG Pathways
*************

* `Purine metabolism <http://www.genome.jp/dbget-bin/show_pathway?hsa00230+374659>`_

.. _HDDC3 GeneRIF:

GeneRIFs
********

* Affinity Capture-MS [`PMID 21890473`_]
* Two-hybrid [`PMID 16189514`_]
* Mesh1, encoded by HDDC3 in humans, contains an active site for ppGpp hydrolysis and a conserved His-Asp-box motif for Mn(2+) binding. It catalyzes hydrolysis of ppGpp both in vitro and in vivo. [`PMID 20818390`_]

.. _PMID 21890473: http://www.ncbi.nlm.nih.gov/pubmed/21890473
.. _PMID 16189514: http://www.ncbi.nlm.nih.gov/pubmed/16189514
.. _PMID 20818390: http://www.ncbi.nlm.nih.gov/pubmed/20818390

.. _HDDC3 Pubmed:

PubMed Articles
***************

*Recent articles:*

* Wagner SA et al. "A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles." Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. `PMID 21890473`_
* Sun D et al. "A metazoan ortholog of SpoT hydrolyzes ppGpp and functions in starvation responses." Nat Struct Mol Biol. 2010 Oct;17(10):1188-94. `PMID 20818390`_
* Lamesch P et al. "hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes." Genomics. 2007 Mar;89(3):307-15. `PMID 17207965`_
* Zody MC et al. "Analysis of the DNA sequence and duplication history of human chromosome 15." Nature. 2006 Mar 30;440(7084):671-5. `PMID 16572171`_
* Rual JF et al. "Towards a proteome-scale map of the human protein-protein interaction network." Nature. 2005 Oct 20;437(7062):1173-8. `PMID 16189514`_
* Gerhard DS et al. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." Genome Res. 2004 Oct;14(10B):2121-7. `PMID 15489334`_
* Ota T et al. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat Genet. 2004 Jan;36(1):40-5. `PMID 14702039`_
* Strausberg RL et al. "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences." Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. `PMID 12477932`_

.. _PMID 21890473: http://www.ncbi.nlm.nih.gov/pubmed/21890473
.. _PMID 16189514: http://www.ncbi.nlm.nih.gov/pubmed/16189514
.. _PMID 14702039: http://www.ncbi.nlm.nih.gov/pubmed/14702039
.. _PMID 17207965: http://www.ncbi.nlm.nih.gov/pubmed/17207965
.. _PMID 12477932: http://www.ncbi.nlm.nih.gov/pubmed/12477932
.. _PMID 20818390: http://www.ncbi.nlm.nih.gov/pubmed/20818390
.. _PMID 16572171: http://www.ncbi.nlm.nih.gov/pubmed/16572171
.. _PMID 15489334: http://www.ncbi.nlm.nih.gov/pubmed/15489334