.. _IDE: IDE ^^^ .. contents:: :local: General Information ******************* :Full gene name: insulin-degrading enzyme :Entrez Gene ID: 3416 :Location: 10q23-q25 :Synonyms: INSULYSIN :Type: protein-coding User SNPs ********* SNPs given by the user that are near or inside this gene: +-----------+---------------+-----------+ | SNP | Distance (bp) | Direction | +===========+===============+===========+ | rs1111875 | 129030 | upstream | +-----------+---------------+-----------+ .. _IDE Gene summary: NCBI Summary ************ This gene encodes a zinc metallopeptidase that degrades intracellular \ ``insulin``\ , and thereby terminates \ ``insulin``\ s activity, as well as participating in intercellular peptide signalling by degrading diverse peptides such as glucagon, amylin, bradykinin, and kallidin. The preferential affinity of this enzyme for \ ``insulin``\ results in \ ``insulin``\ -mediated inhibition of the degradation of other peptides such as beta-amyloid. Deficiencies in this protein's function are associated with Alzheimer's disease and type 2 \ ``diabetes``\ mellitus but mutations in this gene have not been shown to be causitive for these diseases. This protein localizes primarily to the cytoplasm but in some cell types localizes to the extracellular space, cell membrane, peroxisome, and mitochondrion. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Additional transcript variants have been described but have not been experimentally verified.[provided by RefSeq, Sep 2009] .. _OMIM ID 146680 : http://omim.org/entry/146680 .. _IDE OMIM Text: OMIM **** :OMIM ID: `OMIM ID 146680 `_ .. _IDE Phenotype: NCBI Phenotypes *************** * Twelve type 2 \ ``diabetes``\ susceptibility loci identified through large-scale association analysis. * NHGRI GWA Catalog .. _IDE GO Term: Gene Ontology ************* * glycoprotein binding * protein homodimerization activity * cytosol * cytoplasm * zinc ion binding * peroxisomal matrix * mitochondrion * cell surface * proteolysis * ubiquitin homeostasis * hormone catabolic process * extracellular space * protein binding * metalloendopeptidase activity * ATP binding * proteolysis involved in cellular protein catabolic process * beta-amyloid binding * ATPase activity * plasma membrane * peptide binding * positive regulation of protein oligomerization * peroxisome * bradykinin catabolic process * protein heterooligomerization * nucleus * determination of adult lifespan * ubiquitin binding * negative regulation of proteolysis * receptor binding * protein homotetramerization * beta-amyloid metabolic process * cytosolic proteasome complex * beta-endorphin binding * \ ``insulin``\ receptor signaling pathway * protein homooligomerization * interspecies interaction between organisms * \ ``insulin``\ binding .. _IDE Pathway: KEGG Pathways ************* * `Alzheimer's disease `_ .. _IDE GeneRIF: GeneRIFs ******** * Allele and genotype frequency distribution for three markers of \ ``insulin``\ ase differed only in the sample of females between T2D patients and control , while only in case of rs7078413 SNP genotype frequencies varied significantly in the total population [`PMID 19239107`_] * IDE knockout mice show significantly elevated levels of blood \ ``insulin``\ , brain beta-amyloid, and brain amyloid-precursor protein intracellular domain, providing key in vivo evidence that IDE degrades both extracellular and intracellular peptides. [`PMID 12634421`_] * dimers of \ ``insulin``\ -degrading enzyme reveal a cis activation mechanism [`PMID 21343292`_] * analysis of over 2,400 samples provides no compelling evidence that variation in IDE contributes to \ ``diabetes``\ susceptibility in humans [`PMID 12716770`_] * Affinity Capture-MS [`PMID 21903422`_] * IDE gene polymorphisms do not confer susceptibility to early- or late-onset AD at least in a Japanese population. [`PMID 14755451`_] * structural basis of how the high dipole moment of substrates complements the charge distribution of the IDE catalytic chamber for the substrate selectivity [`PMID 19896952`_] * Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator) [`PMID 20628086`_] * Polymorphisms in the IDE-KIF11-HHEX gene locus are associated with susceptibility to type 2 \ ``diabetes``\ across the boundary of race. [`PMID 17971426`_] * Polymorphism in this enzyme are associated with NIDDM in men. [`PMID 12765971`_] * The association of low birth weight and type 2 \ ``diabetes``\ risk alleles of the HHEX-IDE locus is confirmed in children of mothers with type 1 \ ``diabetes``\ . [`PMID 19622614`_] * Affinity Capture-MS [`PMID 20360068`_] * HHEX, IDE and SLC30A8 showed strongest tissue-specific mRNA expression bias and are associated with increased risk of type 2 diabete. [`PMID 20703447`_] * the catalytic mechanisms for the hydrolysis of the three different peptide bonds of Alzheimer amyloid beta (Abeta) peptide by \ ``insulin``\ -degrading enzyme (IDE) [`PMID 20033747`_] * First demonstration of IDE in normal and neoplastic human mammary tissues, providing an experimental starting point towards exploring a potential role of IDE in the control of tumor progression. [`PMID 17143514`_] * IDE protein was expressed in all the tissues assessed and all the tumor cell lines except for Raji and HL-60. [`PMID 18783335`_] * \ ``Insulin``\ -degrading enzyme rapidly removes the beta-amyloid precursor protein intracellular domain (AICD). [`PMID 11809755`_] * the catalytic domain of \ ``insulin``\ -degrading enzyme forms a denaturant-resistant complex with amyloid beta peptide [`PMID 18411275`_] * genomic region in the proximity of IDE that may contribute to Alzheimer and Parkinson disease in a similar manner. [`PMID 15088150`_] * IDE cleaves ubiquitin in a biphasic manner [`PMID 21185309`_] * Reconstituted Complex [`PMID 21800051`_] * there is an association between PPARG, KCNJ11, CDKAL1, CDKN2A-CDKN2B, IDE-KIF11-HHEX, IGF2BP2 and SLC30A8 and type 2 \ ``diabetes``\ in the Chinese population [`PMID 19862325`_] * To test the hypothesis that \ ``insulin``\ might upregulate IDE via a negative feedback control mechanism, we used both in vitro and in vivo strategies to determine the impact of \ ``insulin``\ signaling on IDE levels. [`PMID 15590928`_] * the evolutionarily conserved IDE may play a key role in modulating and reshaping the strength and duration of NP-mediated signaling. [`PMID 21098034`_] * a previously unreported variant unequivocally associated with increased IDE expression was also associated with reduced plasma Abeta40 and decreased LOAD susceptibility [`PMID 20098734`_] * IDE is targeted to mitochondria via alternative initiation of translation. [`PMID 15285718`_] * Results indicate that alleles of IDE contribute to variability in A beta deposition in the AD brain and suggest that this relationship may have relevance for the degree of cognitive dysfunction in AD patients. [`PMID 15718037`_] * this study more generally suggests an interplay between RB and IDE within the proteasome that may have important growth-regulatory consequences. [`PMID 20362553`_] * The upstream polymorphism IDE2 was found to influence AD risk and to trigger the Abeta42 plasma level, whereas the downstream polymorphism IDE7 modified the T2DM risk; no associations were found for the intronic variant IDE9. [`PMID 22107728`_] * Biochemical characteristics of \ ``insulin``\ degradation in wound fluid were consistent with characteristics of \ ``insulin``\ -degrading enzyme. Reduction in \ ``insulin``\ -degrading activity in wound fluid is potential therapeutic target. [`PMID 14764804`_] * The C allele of single-nucleotide polymorphism IDE2 associated with Alzheimer disease. There may be a possible synergic interaction between IDE & APOE epsilon4. [`PMID 15277615`_] * Reconstituted Complex [`PMID 1733942`_] * Reconstituted Complex [`PMID 1733942`_] * BRI2 protein regulates beta-amyloid degradation by increasing levels of secreted \ ``insulin``\ -degrading enzyme (IDE). [`PMID 21873424`_] * This study systematically characterizes IDE mRNAs, identifies a novel, catalytically inefficient splice form and compares its subcellular distribution, kinetic properties and ability to degrade amyloid beta protein to the known isoform. [`PMID 15850385`_] * present study provides evidence that IDE promoter polymorphisms that significantly decrease IDE expression levels are associated with development of sporadic lzheimer disease [`PMID 18996360`_] * possible mechanism by which the \ ``insulin``\ -degrading enzyme (IDE) zinc-binding protease carries out its catalytic function toward two peptides of different length [`PMID 19785409`_] * kinetics and regulation of human IDE with short peptides [`PMID 18986166`_] * Study verified associations of two IDE polymorphisms (rs1887922 and rs2149632) with type 2 \ ``diabetes``\ risk in two independent German cohorts and evaluated in detail the association of common variants with \ ``insulin``\ metabolism and glycemic traits. [`PMID 19809796`_] * Here we show that a combination of risk genotypes for NEP and IDE genes leads to a higher susceptibility to AD. [`PMID 19864659`_] * IDE protease binds to the 73-kDa gE precursor and that this event occurs in the cytosol but not as a receptor/ligand interaction. [`PMID 19864391`_] * Meta-analysis of gene-disease association. (HuGE Navigator) [`PMID 17913278`_] * Variations in IDE may contribute to \ ``diabetes``\ susceptibility in the Korean population. [`PMID 17913278`_] * Cys-178 has a role in preventing inactivation and oligomerization of human \ ``insulin``\ -degrading enzyme by oxidation and nitrosylation [`PMID 19808678`_] * \ ``Insulin``\ degrading enzyme is linked with aggregated Abeta40 isoform while neprilysin negatively correlates with amyloid angiopathy. [`PMID 19019493`_] * IDE-N is the catalytic domain and IDE-C facilitates substrate recognition as well as plays a key role in the oligomerization of IDE. [`PMID 16574064`_] * Observational study of gene-disease association. (HuGE Navigator) [`PMID 20877624`_] * Affinity Capture-MS; Affinity Capture-Western [`PMID 17715127`_] * Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator) [`PMID 20384434`_] * In comparison to Abeta40, Abeta42 is more flexible and interacts through a smaller number (17-22) of hydrogen bonds in the catalytic chamber of IDE. [`PMID 20380468`_] * Data suggest that HEs-1/Hey-1 transcriptional modulation of \ ``insulin``\ degrading enzyme may impact amyloid beta metabolism by providing a functional link between Notch signaling and the amyloidogenic pathway. [`PMID 22036964`_] * Phosphorylation of amyloid-beta peptide at serine 8 attenuates its clearance via \ ``insulin``\ -degrading and angiotensin-converting enzymes. [`PMID 22267728`_] * produce tumor antigenic peptides presented by MHC class I molecules for cytotoxic T lymphocyte recognition [`PMID 20364150`_] * Meta-analysis and HuGE review of gene-disease association. (HuGE Navigator) [`PMID 19602701`_] * Meta-analysis and genome-wide association study of gene-disease association. (HuGE Navigator) [`PMID 17463249`_] * when intracellular long-chain fatty acid concentrations are elevated, they may act directly on \ ``insulin``\ -degrading enzyme to decrease \ ``insulin``\ metabolism and alter \ ``insulin``\ action in intact cells and this mechanism may contribute to \ ``insulin``\ resistance [`PMID 12746301`_] * Beta-amyloid degradation is largely the result of the action of IDE, as it is blocked by \ ``insulin``\ in the medium, a competitive substrate of IDE. IDE could be an important therapeutic target to decrease the amount of Abeta in the cerebrovasculature. [`PMID 16511862`_] * This study provides strong evidence for pathogenic variant(s) in the 276-kb region harboring IDE that influence intermediate Alzheimer's disease phenotypes and risk for AD. [`PMID 15024728`_] * Different reconstructed \ ``insulin``\ -degrading enzyme haplotypes were associated with Alzheimers disease and lower cognitive ability. [`PMID 16675064`_] * protein structures of human IDE in complex with four substrates (\ ``insulin``\ B chain, amyloid-beta peptide (1-40), amylin and glucagon) [`PMID 17051221`_] * Significant differences were found in the response to induced ketosis among non-carriers of putative gain-of-function polymorphisms in rs1143627 and rs16944 in the IL-1beta gene and among variants of the polymorphism rs2251101 in the insulysin gene. [`PMID 21992747`_] * The single nucleotide polymorphism rs2209972 in the human IDE gene is associated with metabolic features of polycystic ovary syndrome women in a Chinese population. [`PMID 17953957`_] * SNPs rs4646953 & rs4646955 are associated with Alzheimer disease in Finnish patients, conferring an approximately two-fold increased risk. [`PMID 17496198`_] * Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator) [`PMID 20880607`_] * IDE gene promoter region variants are associated with AD in subjects without an epsilon4 allele [`PMID 15181249`_] * Located on chromosome 10 and suscptibility of polymorphisms are related to type 2 \ ``diabetes``\ . [`PMID 19053027`_] * This study demenostrated that \ ``insulin``\ -degrading enzyme levels is increased in Alzheimer disease in relation to disease severity. [`PMID 19606063`_] * IDE forms an enclosed catalytic chamber that completely engulfs and intimately interacts with a partially unfolded \ ``insulin``\ molecule. [`PMID 19321446`_] * This study suggests IDE may be indirectly related to dementia via its regulation of \ ``insulin``\ levels, but it is not a major gene for Alzheimer's. [`PMID 17192720`_] * The combined genotype data from 1269 late-onset AD cases and 980 controls yielded a significant association to IDE_9 located in the 3'-end of the IDE gene after conservative multiple testing Bonferroni correction (p = 0.005). [`PMID 16876916`_] * Polymorphism in/near IDE contributes to a large proportion of variance in plasma \ ``insulin``\ levels and correlated traits. [`PMID 15277398`_] * IIA(Glc) of the sugar phosphotransferase system regulates the peptidase activity of a mammalian insulysin homolog in V. vulnificus. [`PMID 20971110`_] * Importance of the distribution of the enzyme in brain and pituitary is discussed in relation to its main known substrataes. [`PMID 18226493`_] * Results describe the in vitro degradation of \ ``insulin``\ -like peptide 3 by \ ``insulin``\ -degrading enzyme. [`PMID 20082125`_] * a defect in Abeta proteolysis by IDE contributes to the accumulation of this peptide in the cortical microvasculature [`PMID 15489232`_] * Co-purification [`PMID 8051160`_] * These results suggest that PPARgamma transcriptionally induces IDE expression. [`PMID 19383491`_] * This shows that IDE is involved in cellular \ ``insulin``\ metabolism and provides further evidence that \ ``insulin``\ inhibits protein degradation via an interaction with IDE. [`PMID 17964527`_] * \ ``Insulin``\ -degrading enzyme protein expression was found in normal tissues of the kidney, liver, lung, brain, breast and skeletal muscle, as well as in breast and ovarian cancer tissues. [`PMID 18813847`_] * This result suggests that the IDE gene might contribute to metabolic syndrome susceptibility in Chinese elders [`PMID 19592050`_] * the genetic linkage of AD in this set of chromosome 10-linked AD families may be the result of systemic defects in IDE activity in the absence of altered IDE expression [`PMID 17244626`_] * Observational study and genome-wide association study of gene-disease association. (HuGE Navigator) [`PMID 17293876`_] * cellular receptor for infection by varicella-zoster virus. Interacts with VZV glycoprotein E. [`PMID 17055432`_] * Observational study and meta-analysis of gene-disease association. (HuGE Navigator) [`PMID 20927120`_] * Loss of \ ``insulin``\ -induced regulation of IDE activity under hyperglycaemia may contribute to the reduced \ ``insulin``\ extraction and peripheral hyper\ ``insulin``\ aemia in type 2 \ ``diabetes``\ . [`PMID 19396426`_] * Affinity Capture-MS [`PMID 21906983`_] * predict that alkylation of C812 and C819 disrupts substrate binding, whereas alkylation of C178 interferes with the apposition of active-site domains and subtly repositions zinc-binding residues [`PMID 18621727`_] * IDE is not correlated with amyloig beta or clinical diagnosis Alzheimer disease [`PMID 20663017`_] * Five IDE variants for altered in vitro reporter gene expression, based on their presence on haplotypes (H2, H6 and H9) and their association with altered IDE mRNA transcript levels , were tested. [`PMID 21731745`_] * the same genetic HHEX-IDE variant, which is associated with type 2 \ ``diabetes``\ from previous studies, also influences pediatric body mass index [`PMID 19933996`_] * Results suggest a relationship between a gene that is intimately involved in \ ``insulin``\ metabolism and the determination of lifespan in humans. [`PMID 18448515`_] * Common genetic variation at IDE is unlikely to confer clinically significant risk of type 2 \ ``diabetes``\ in Caucasians. [`PMID 16380485`_] .. _PMID 19239107: http://www.ncbi.nlm.nih.gov/pubmed/19239107 .. _PMID 12634421: http://www.ncbi.nlm.nih.gov/pubmed/12634421 .. _PMID 21343292: http://www.ncbi.nlm.nih.gov/pubmed/21343292 .. _PMID 12716770: http://www.ncbi.nlm.nih.gov/pubmed/12716770 .. _PMID 21903422: http://www.ncbi.nlm.nih.gov/pubmed/21903422 .. _PMID 14755451: http://www.ncbi.nlm.nih.gov/pubmed/14755451 .. _PMID 19896952: http://www.ncbi.nlm.nih.gov/pubmed/19896952 .. _PMID 20628086: http://www.ncbi.nlm.nih.gov/pubmed/20628086 .. _PMID 17971426: http://www.ncbi.nlm.nih.gov/pubmed/17971426 .. _PMID 12765971: http://www.ncbi.nlm.nih.gov/pubmed/12765971 .. _PMID 19622614: http://www.ncbi.nlm.nih.gov/pubmed/19622614 .. _PMID 20360068: http://www.ncbi.nlm.nih.gov/pubmed/20360068 .. _PMID 20703447: http://www.ncbi.nlm.nih.gov/pubmed/20703447 .. _PMID 20033747: http://www.ncbi.nlm.nih.gov/pubmed/20033747 .. _PMID 17143514: http://www.ncbi.nlm.nih.gov/pubmed/17143514 .. _PMID 18783335: http://www.ncbi.nlm.nih.gov/pubmed/18783335 .. _PMID 11809755: http://www.ncbi.nlm.nih.gov/pubmed/11809755 .. _PMID 18411275: http://www.ncbi.nlm.nih.gov/pubmed/18411275 .. _PMID 15088150: http://www.ncbi.nlm.nih.gov/pubmed/15088150 .. _PMID 21185309: http://www.ncbi.nlm.nih.gov/pubmed/21185309 .. _PMID 21800051: http://www.ncbi.nlm.nih.gov/pubmed/21800051 .. _PMID 19862325: http://www.ncbi.nlm.nih.gov/pubmed/19862325 .. _PMID 15590928: http://www.ncbi.nlm.nih.gov/pubmed/15590928 .. _PMID 21098034: http://www.ncbi.nlm.nih.gov/pubmed/21098034 .. _PMID 20098734: http://www.ncbi.nlm.nih.gov/pubmed/20098734 .. _PMID 15285718: http://www.ncbi.nlm.nih.gov/pubmed/15285718 .. _PMID 15718037: http://www.ncbi.nlm.nih.gov/pubmed/15718037 .. _PMID 20362553: http://www.ncbi.nlm.nih.gov/pubmed/20362553 .. _PMID 22107728: http://www.ncbi.nlm.nih.gov/pubmed/22107728 .. _PMID 14764804: http://www.ncbi.nlm.nih.gov/pubmed/14764804 .. _PMID 15277615: http://www.ncbi.nlm.nih.gov/pubmed/15277615 .. _PMID 1733942: http://www.ncbi.nlm.nih.gov/pubmed/1733942 .. _PMID 21873424: http://www.ncbi.nlm.nih.gov/pubmed/21873424 .. _PMID 15850385: http://www.ncbi.nlm.nih.gov/pubmed/15850385 .. _PMID 18996360: http://www.ncbi.nlm.nih.gov/pubmed/18996360 .. _PMID 19785409: http://www.ncbi.nlm.nih.gov/pubmed/19785409 .. _PMID 18986166: http://www.ncbi.nlm.nih.gov/pubmed/18986166 .. _PMID 19809796: http://www.ncbi.nlm.nih.gov/pubmed/19809796 .. _PMID 19864659: http://www.ncbi.nlm.nih.gov/pubmed/19864659 .. _PMID 19864391: http://www.ncbi.nlm.nih.gov/pubmed/19864391 .. _PMID 17913278: http://www.ncbi.nlm.nih.gov/pubmed/17913278 .. _PMID 19808678: http://www.ncbi.nlm.nih.gov/pubmed/19808678 .. _PMID 19019493: http://www.ncbi.nlm.nih.gov/pubmed/19019493 .. _PMID 16574064: http://www.ncbi.nlm.nih.gov/pubmed/16574064 .. _PMID 20877624: http://www.ncbi.nlm.nih.gov/pubmed/20877624 .. _PMID 17715127: http://www.ncbi.nlm.nih.gov/pubmed/17715127 .. _PMID 20384434: http://www.ncbi.nlm.nih.gov/pubmed/20384434 .. _PMID 20380468: http://www.ncbi.nlm.nih.gov/pubmed/20380468 .. _PMID 22036964: http://www.ncbi.nlm.nih.gov/pubmed/22036964 .. _PMID 22267728: http://www.ncbi.nlm.nih.gov/pubmed/22267728 .. _PMID 20364150: http://www.ncbi.nlm.nih.gov/pubmed/20364150 .. _PMID 19602701: http://www.ncbi.nlm.nih.gov/pubmed/19602701 .. _PMID 17463249: http://www.ncbi.nlm.nih.gov/pubmed/17463249 .. _PMID 12746301: http://www.ncbi.nlm.nih.gov/pubmed/12746301 .. _PMID 16511862: http://www.ncbi.nlm.nih.gov/pubmed/16511862 .. _PMID 15024728: http://www.ncbi.nlm.nih.gov/pubmed/15024728 .. _PMID 16675064: http://www.ncbi.nlm.nih.gov/pubmed/16675064 .. _PMID 17051221: http://www.ncbi.nlm.nih.gov/pubmed/17051221 .. _PMID 21992747: http://www.ncbi.nlm.nih.gov/pubmed/21992747 .. _PMID 17953957: http://www.ncbi.nlm.nih.gov/pubmed/17953957 .. _PMID 17496198: http://www.ncbi.nlm.nih.gov/pubmed/17496198 .. _PMID 20880607: http://www.ncbi.nlm.nih.gov/pubmed/20880607 .. _PMID 15181249: http://www.ncbi.nlm.nih.gov/pubmed/15181249 .. _PMID 19053027: http://www.ncbi.nlm.nih.gov/pubmed/19053027 .. _PMID 19606063: http://www.ncbi.nlm.nih.gov/pubmed/19606063 .. _PMID 19321446: http://www.ncbi.nlm.nih.gov/pubmed/19321446 .. _PMID 17192720: http://www.ncbi.nlm.nih.gov/pubmed/17192720 .. _PMID 16876916: http://www.ncbi.nlm.nih.gov/pubmed/16876916 .. _PMID 15277398: http://www.ncbi.nlm.nih.gov/pubmed/15277398 .. _PMID 20971110: http://www.ncbi.nlm.nih.gov/pubmed/20971110 .. _PMID 18226493: http://www.ncbi.nlm.nih.gov/pubmed/18226493 .. _PMID 20082125: http://www.ncbi.nlm.nih.gov/pubmed/20082125 .. _PMID 15489232: http://www.ncbi.nlm.nih.gov/pubmed/15489232 .. _PMID 8051160: http://www.ncbi.nlm.nih.gov/pubmed/8051160 .. _PMID 19383491: http://www.ncbi.nlm.nih.gov/pubmed/19383491 .. _PMID 17964527: http://www.ncbi.nlm.nih.gov/pubmed/17964527 .. _PMID 18813847: http://www.ncbi.nlm.nih.gov/pubmed/18813847 .. _PMID 19592050: http://www.ncbi.nlm.nih.gov/pubmed/19592050 .. _PMID 17244626: http://www.ncbi.nlm.nih.gov/pubmed/17244626 .. _PMID 17293876: http://www.ncbi.nlm.nih.gov/pubmed/17293876 .. _PMID 17055432: http://www.ncbi.nlm.nih.gov/pubmed/17055432 .. _PMID 20927120: http://www.ncbi.nlm.nih.gov/pubmed/20927120 .. _PMID 19396426: http://www.ncbi.nlm.nih.gov/pubmed/19396426 .. _PMID 21906983: http://www.ncbi.nlm.nih.gov/pubmed/21906983 .. _PMID 18621727: http://www.ncbi.nlm.nih.gov/pubmed/18621727 .. _PMID 20663017: http://www.ncbi.nlm.nih.gov/pubmed/20663017 .. _PMID 21731745: http://www.ncbi.nlm.nih.gov/pubmed/21731745 .. _PMID 19933996: http://www.ncbi.nlm.nih.gov/pubmed/19933996 .. _PMID 18448515: http://www.ncbi.nlm.nih.gov/pubmed/18448515 .. _PMID 16380485: http://www.ncbi.nlm.nih.gov/pubmed/16380485 .. _IDE Pubmed: PubMed Articles *************** *Recent articles:* * Kumar S et al. "Phosphorylation of amyloid-β peptide at serine 8 attenuates its clearance via insulin-degrading and angiotensin-converting enzymes." J Biol Chem. 2012 Mar 9;287(11):8641-51. `PMID 22267728`_ * Leal MC et al. "Notch signaling proteins HES-1 and Hey-1 bind to insulin degrading enzyme (IDE) proximal promoter and repress its transcription and activity: implications for cellular Aβ metabolism." Biochim Biophys Acta. 2012 Feb;1823(2):227-35. `PMID 22036964`_ * Fang Y et al. "The interaction between ubiquitin C-terminal hydrolase 37 and glucose-regulated protein 78 in hepatocellular carcinoma." Mol Cell Biochem. 2012 Jan;359(1-2):59-66. `PMID 21800051`_ * Bartl J et al. "Disorder-specific effects of polymorphisms at opposing ends of the Insulin Degrading Enzyme gene." BMC Med Genet. 2011 Nov 22;12:151. `PMID 22107728`_ * Kilger E et al. "BRI2 protein regulates β-amyloid degradation by increasing levels of secreted insulin-degrading enzyme (IDE)." J Biol Chem. 2011 Oct 28;286(43):37446-57. `PMID 21873424`_ * Kim W et al. "Systematic and quantitative assessment of the ubiquitin-modified proteome." Mol Cell. 2011 Oct 21;44(2):325-40. `PMID 21906983`_ * Henderson ST et al. "Pharmacogenetic analysis of the effects of polymorphisms in APOE, IDE and IL1B on a ketone body based therapeutic on cognition in mild to moderate Alzheimer's disease; a randomized, double-blind, placebo-controlled study." BMC Med Genet. 2011 Oct 12;12:137. `PMID 21992747`_ * Wagner SA et al. "A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles." Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. `PMID 21890473`_ * Li S et al. "Mapping a dynamic innate immunity protein interaction network regulating type I interferon production." Immunity. 2011 Sep 23;35(3):426-40. `PMID 21903422`_ * Belbin O et al. "Multiple insulin degrading enzyme variants alter in vitro reporter gene expression." PLoS One. 2011;6(6):e21429. `PMID 21731745`_ .. _PMID 21890473: http://www.ncbi.nlm.nih.gov/pubmed/21890473 .. _PMID 21873424: http://www.ncbi.nlm.nih.gov/pubmed/21873424 .. _PMID 21800051: http://www.ncbi.nlm.nih.gov/pubmed/21800051 .. _PMID 21992747: http://www.ncbi.nlm.nih.gov/pubmed/21992747 .. _PMID 22036964: http://www.ncbi.nlm.nih.gov/pubmed/22036964 .. _PMID 21903422: http://www.ncbi.nlm.nih.gov/pubmed/21903422 .. _PMID 22107728: http://www.ncbi.nlm.nih.gov/pubmed/22107728 .. _PMID 21731745: http://www.ncbi.nlm.nih.gov/pubmed/21731745 .. _PMID 22267728: http://www.ncbi.nlm.nih.gov/pubmed/22267728 .. _PMID 21906983: http://www.ncbi.nlm.nih.gov/pubmed/21906983 *Top Pubmed articles linked to gene IDE matching any search term:* * Zhang L et al. "Nuclear Respiratory Factor 1 Mediates the Transcription Initiation of Insulin-Degrading Enzyme in a TATA Box-Binding Protein-Independent Manner." PLoS One. 2012;7(8):e42035. `PMID 22870279`_ * Cabibbo G et al. "Causes of and prevention strategies for hepatocellular carcinoma." Semin Oncol. 2012 Aug;39(4):374-83. `PMID 22846856`_ * Bartl J et al. "Different effects of soluble and aggregated amyloid β(42) on gene/protein expression and enzyme activity involved in insulin and APP pathways." J Neural Transm. 2012 Jul 11;. `PMID 22782687`_ * Matsushita K et al. "Glycolysis inhibitors as a potential therapeutic option to treat aggressive neuroblastoma expressing GLUT1." J Pediatr Surg. 2012 Jul;47(7):1323-30. `PMID 22813791`_ * Kukday SS et al. "Cell-Permeable, Small-Molecule Activators of the Insulin-Degrading Enzyme." J Biomol Screen. 2012 Jun 26;. `PMID 22740246`_ * Grasso G et al. "Metal ions affect insulin-degrading enzyme activity." J Inorg Biochem. 2012 Jun 23;. `PMID 22819648`_ * Lin YL et al. "The Components of Flemingia macrophylla Attenuate Amyloid β-Protein Accumulation by Regulating Amyloid β-Protein Metabolic Pathway." Evid Based Complement Alternat Med. 2012;2012:795843. `PMID 22719789`_ * Kim YG et al. "Peptidomics approach to elucidate the proteolytic regulation of bioactive peptides." Proc Natl Acad Sci U S A. 2012 May 29;109(22):8523-7. `PMID 22586115`_ * Gallagher JJ et al. "Impaired Performance of Female APP/PS1 Mice in the Morris Water Maze Is Coupled with Increased Aβ Accumulation and Microglial Activation." Neurodegener Dis. 2012 May 24;. `PMID 22627185`_ * Lhuillier O et al. "[A clinical monitoring tool for diabetic patients for the benefit of freelance nurses]." Soins. 2012 Apr;(764):46-8. `PMID 22641947`_ * Leal MC et al. "Notch signaling proteins HES-1 and Hey-1 bind to insulin degrading enzyme (IDE) proximal promoter and repress its transcription and activity: implications for cellular Aβ metabolism." Biochim Biophys Acta. 2012 Feb;1823(2):227-35. `PMID 22036964`_ * Bartl J et al. "Disorder-specific effects of polymorphisms at opposing ends of the Insulin Degrading Enzyme gene." 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