.. _IGF2BP2: IGF2BP2 ^^^^^^^ .. contents:: :local: General Information ******************* :Full gene name: insulin-like growth factor 2 mRNA binding protein 2 :Entrez Gene ID: 10644 :Location: 3q27.2 :Synonyms: IMP2, p62, IMP-2, VICKZ2 :Type: protein-coding User SNPs ********* SNPs given by the user that are near or inside this gene: +-----------+---------------+-----------+ | SNP | Distance (bp) | Direction | +===========+===============+===========+ | rs1470579 | 0 | within | +-----------+---------------+-----------+ .. _IGF2BP2 Gene summary: NCBI Summary ************ This gene encodes a member of the IGF-II mRNA-binding protein (IMP) family. The protein encoded by this gene contains several four KH domains and two RRM domains. It functions by binding to the 5' UTR of the \ ``insulin``\ -like growth factor 2 (IGF2) mRNA and regulating IGF2 translation. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008] .. _OMIM ID 608289 : http://omim.org/entry/608289 .. _IGF2BP2 OMIM Text: OMIM **** :OMIM ID: `OMIM ID 608289 `_ **Allelic Variants (Selected Examples)** .0001 \ ``DIABETES``\ MELLITUS, NONINSULIN-DEPENDENT, SUSCEPTIBILITY TO In genomewide association studies of type 2 \ ``DIABETES``\ (125853), the \ ``DIABETES``\ Genetics Initiative of Broad Institute of Harvard and MIT, Lund University, and Novartis Institutes for BioMedical Research (2007), Zeggini et al. (2007), and Scott et al. (2007) found that the T allele of rs4402960 confers increased susceptibility to type 2 \ ``DIABETES``\ . Combined analyses obtained a P value of 8.9 x 10(-16). .. _IGF2BP2 Phenotype: NCBI Phenotypes *************** * Gene Reviews * A genome-wide association study of gestational \ ``diabetes``\ mellitus in Korean women. * Meta-analysis of genome-wide association data and large-scale replication identifies additional susceptibility loci for type 2 \ ``diabetes``\ . * Genome-wide association study of type 2 \ ``diabetes``\ in a sample from Mexico City and a meta-analysis of a Mexican-American sample from Starr County, Texas. * \ ``Diabetes``\ mellitus type 2 * Twelve type 2 \ ``diabetes``\ susceptibility loci identified through large-scale association analysis. * Confirmation of multiple risk Loci and genetic impacts by a genome-wide association study of type 2 \ ``diabetes``\ in the Japanese population. * OMIM * Stratifying Type 2 \ ``Diabetes``\ Cases by BMI Identifies Genetic Risk Variants in LAMA1 and Enrichment for Risk Variants in Lean Compared to Obese Cases. * A genome-wide association study of type 2 \ ``diabetes``\ in Finns detects multiple susceptibility variants. * GTR * Genome-wide association analysis identifies loci for type 2 \ ``diabetes``\ and triglyceride levels. * Replication of genome-wide association signals in UK samples reveals risk loci for type 2 \ ``diabetes``\ . * NHGRI GWA Catalog * SNPs in KCNQ1 are associated with susceptibility to type 2 \ ``diabetes``\ in East Asian and European populations. * Hundreds of variants clustered in genomic loci and biological pathways affect human height. .. _IGF2BP2 GO Term: Gene Ontology ************* * cytosol * protein binding * regulation of cytokine biosynthetic process * cytoskeletal part * nucleus * translation regulator activity * cytoplasm * mRNA 3'-UTR binding * negative regulation of translation * nucleotide binding * mRNA 5'-UTR binding * anatomical structure morphogenesis .. _IGF2BP2 Pathway: KEGG Pathways ************* No pathways found linked to this gene. .. _IGF2BP2 GeneRIF: GeneRIFs ******** * Observational study and genome-wide association study of gene-disease association. (HuGE Navigator) [`PMID 19401414`_] * Affinity Capture-MS [`PMID 17620599`_] * Affinity Capture-MS [`PMID 17353931`_] * HMGA2 differentially regulates expression of IMP family members during mouse embryogenesis. [`PMID 15225648`_] * Observational study of gene-disease association, gene-gene interaction, gene-environment interaction, and genetic testing. (HuGE Navigator) [`PMID 20075150`_] * Study suggests that there is a significant association between expression of IMP-2 and the growth of tumor cells, in which IMP-2 is associated with apoptosis induced by tretinoin. [`PMID 15618018`_] * Meta-analysis and HuGE review of gene-disease association. (HuGE Navigator) [`PMID 19602701`_] * VICKZ exhibits differential expression in lymphoma subtypes and thus may be a marker of potential value in the diagnosis and study of hematopoietic neoplasia. [`PMID 17296566`_] * Data reveal how the posttranscriptional regulation of gene expression by IMP-2 contributes to the control of adhesion structures and stable microtubules and demonstrate an important function for IMP-2 in cellular motility. [`PMID 20956565`_] * Variants of CDKAL1 and IGF2BP2 attenuate the first phase of \ ``glucose``\ -stimulated \ ``insulin``\ secretion but show no effect on the second phase of \ ``insulin``\ secretion in hyperglycmia and type 2 \ ``diabetes``\ . [`PMID 18618095`_] * involved in the selective autophagic clearance of non-ubiquitylated aggregation-prone substrates [`PMID 21771882`_] * Observational study of gene-disease association, gene-gene interaction, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator) [`PMID 20879858`_] * we provide evidence that there is a strong and statistically significant correlation between HMGA2 and IMP2 gene expression in human liposarcomas. [`PMID 17426251`_] * Affinity Capture-MS [`PMID 21906983`_] * Affinity Capture-MS [`PMID 17643375`_] * Affinity Capture-MS [`PMID 17643375`_] * Affinity Capture-MS [`PMID 17643375`_] * non-replications of IGF2BP2 associations with type 2 \ ``diabetes``\ [`PMID 20627640`_] * Little evidence of association was observed between SNPs in IGF2BP2 and type 2 \ ``diabetes``\ in African Americans. [`PMID 18443202`_] * Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator) [`PMID 20628086`_] * Six SNP(rs7754840 in CDKAL1, rs391300 in SRR, rs2383208 in CDKN2A/2B, rs4402960 in IGF2BP2, rs10830963 in MTNR1B, rs4607517 in GCK)risk alleles of type 2 \ ``diabetes``\ were associated with GDM in pregnant Chinese women. [`PMID 22096510`_] * IGF2BP2 SNPs revealed a significant association with type 2 \ ``diabetes``\ [`PMID 18598350`_] * findings show that IGF2BP2 rs1470579 and rs4402960 polymorphisms may be associated with the development of type 2 \ ``diabetes``\ and these polymorphisms may affect the therapeutic efficacy of repaglinide in Chinese T2DM patientsmellitus [`PMID 20523342`_] * Affinity Capture-MS [`PMID 20186120`_] * Observational study of gene-disease association, gene-gene interaction, and gene-environment interaction. (HuGE Navigator) [`PMID 20889853`_] * IGF2BP2 stimulation increases radiosensitivity of a pancreatic cancer cell line through endoplasmic reticulum stress under hypoxic comditions. [`PMID 19018773`_] * The induction of a steatotic phenotype implies that p62 plays a role in hepatic pathophysiology [`PMID 21145819`_] * Type 2 \ ``diabetes``\ susceptibility of IGF2BP2 was confirmed in Japanese. [`PMID 19033397`_] * Study show that polymorphisms in IGF2BP2 were associated with type 2 \ ``diabetes``\ risk in the studied population. [`PMID 18694974`_] * Observational study of gene-disease association. (HuGE Navigator) [`PMID 20929593`_] * Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator) [`PMID 20802253`_] * meta-analysis suggested that IGF2BP2 rs4402960 polymorphism conferred elevated risk of T2DM, especially in European, East Asian and South Asian populations [`PMID 21839790`_] * Double phosphorylation promotes IMP2 binding to the IGF2 leader 3 mRNA 5' untranslated region, and the translational initiation of this mRNA [`PMID 21576258`_] * Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator) [`PMID 20203524`_] * Affinity Capture-MS [`PMID 17314511`_] * The IGF2BP2 variant shows a nominal interaction with exposure to famine in wartime in utero and predisposition to type 2 \ ``diabetes``\ . [`PMID 19258437`_] * Meta-analysis and genome-wide association study of gene-disease association. (HuGE Navigator) [`PMID 17463249`_] * Gene variants of CDKAL1, PPARG, IGF2BP2, HHEX, TCF7L2, and FTO predispose to type 2 \ ``diabetes``\ in the German KORA 500 K study population. [`PMID 18597214`_] * Affinity Capture-MS [`PMID 19135240`_] * Affinity Capture-MS [`PMID 22586326`_] * IGF2BP2 single-nucleotide polymorphisms are associated with body fat and this effect on body fat influences \ ``insulin``\ resistance which may contribute to type 2 \ ``diabetes``\ mellitus risk. [`PMID 19148120`_] * Data show that SNPs in IGF2BP2 did not confer a significant risk for type 2 \ ``diabetes``\ in Pima Indians. [`PMID 19008344`_] * Novel evidence for a rare variant in the 3' downstream region of IGF2BP2 in type 2 \ ``diabetes``\ in French Caucasians. [`PMID 18430866`_] * The results indicate that in Chinese Hans, common variants in IGF2BP2 loci independently or additively contribute to type 2 \ ``diabetes``\ risk, likely mediated through beta-cell dysfunction. [`PMID 18633108`_] * Data confirmed the associations of single nucleotide polymorphisms in IGF2BP2 with risk for type 2 \ ``diabetes``\ in Asians. [`PMID 18469204`_] * Observational study and meta-analysis of gene-disease association. (HuGE Navigator) [`PMID 20490451`_] * IGF2BP2 genetic variation is associated with type 2 \ ``diabetes``\ . [`PMID 22032244`_] * The association of 6 loci with type 2 \ ``diabetes``\ risk in Japanese patients is reported. [`PMID 18162508`_] * prostate cancer was inversely associated with the IGF2BP2 rs4402960 T allele [`PMID 20142250`_] * IGF2 is emerging as an important gene for ovarian cancer. [`PMID 21422097`_] .. _PMID 19401414: http://www.ncbi.nlm.nih.gov/pubmed/19401414 .. _PMID 17620599: http://www.ncbi.nlm.nih.gov/pubmed/17620599 .. _PMID 17353931: http://www.ncbi.nlm.nih.gov/pubmed/17353931 .. _PMID 15225648: http://www.ncbi.nlm.nih.gov/pubmed/15225648 .. _PMID 20075150: http://www.ncbi.nlm.nih.gov/pubmed/20075150 .. _PMID 15618018: http://www.ncbi.nlm.nih.gov/pubmed/15618018 .. _PMID 19602701: http://www.ncbi.nlm.nih.gov/pubmed/19602701 .. _PMID 17296566: http://www.ncbi.nlm.nih.gov/pubmed/17296566 .. _PMID 20956565: http://www.ncbi.nlm.nih.gov/pubmed/20956565 .. _PMID 18618095: http://www.ncbi.nlm.nih.gov/pubmed/18618095 .. _PMID 21771882: http://www.ncbi.nlm.nih.gov/pubmed/21771882 .. _PMID 20879858: http://www.ncbi.nlm.nih.gov/pubmed/20879858 .. _PMID 17426251: http://www.ncbi.nlm.nih.gov/pubmed/17426251 .. _PMID 21906983: http://www.ncbi.nlm.nih.gov/pubmed/21906983 .. _PMID 17643375: http://www.ncbi.nlm.nih.gov/pubmed/17643375 .. _PMID 20627640: http://www.ncbi.nlm.nih.gov/pubmed/20627640 .. _PMID 18443202: http://www.ncbi.nlm.nih.gov/pubmed/18443202 .. _PMID 20628086: http://www.ncbi.nlm.nih.gov/pubmed/20628086 .. _PMID 22096510: http://www.ncbi.nlm.nih.gov/pubmed/22096510 .. _PMID 18598350: http://www.ncbi.nlm.nih.gov/pubmed/18598350 .. _PMID 20523342: http://www.ncbi.nlm.nih.gov/pubmed/20523342 .. _PMID 20186120: http://www.ncbi.nlm.nih.gov/pubmed/20186120 .. _PMID 20889853: http://www.ncbi.nlm.nih.gov/pubmed/20889853 .. _PMID 19018773: http://www.ncbi.nlm.nih.gov/pubmed/19018773 .. _PMID 21145819: http://www.ncbi.nlm.nih.gov/pubmed/21145819 .. _PMID 19033397: http://www.ncbi.nlm.nih.gov/pubmed/19033397 .. _PMID 18694974: http://www.ncbi.nlm.nih.gov/pubmed/18694974 .. _PMID 20929593: http://www.ncbi.nlm.nih.gov/pubmed/20929593 .. _PMID 20802253: http://www.ncbi.nlm.nih.gov/pubmed/20802253 .. _PMID 21839790: http://www.ncbi.nlm.nih.gov/pubmed/21839790 .. _PMID 21576258: http://www.ncbi.nlm.nih.gov/pubmed/21576258 .. _PMID 20203524: http://www.ncbi.nlm.nih.gov/pubmed/20203524 .. _PMID 17314511: http://www.ncbi.nlm.nih.gov/pubmed/17314511 .. _PMID 19258437: http://www.ncbi.nlm.nih.gov/pubmed/19258437 .. _PMID 17463249: http://www.ncbi.nlm.nih.gov/pubmed/17463249 .. _PMID 18597214: http://www.ncbi.nlm.nih.gov/pubmed/18597214 .. _PMID 19135240: http://www.ncbi.nlm.nih.gov/pubmed/19135240 .. _PMID 22586326: http://www.ncbi.nlm.nih.gov/pubmed/22586326 .. _PMID 19148120: http://www.ncbi.nlm.nih.gov/pubmed/19148120 .. _PMID 19008344: http://www.ncbi.nlm.nih.gov/pubmed/19008344 .. _PMID 18430866: http://www.ncbi.nlm.nih.gov/pubmed/18430866 .. _PMID 18633108: http://www.ncbi.nlm.nih.gov/pubmed/18633108 .. _PMID 18469204: http://www.ncbi.nlm.nih.gov/pubmed/18469204 .. _PMID 20490451: http://www.ncbi.nlm.nih.gov/pubmed/20490451 .. _PMID 22032244: http://www.ncbi.nlm.nih.gov/pubmed/22032244 .. _PMID 18162508: http://www.ncbi.nlm.nih.gov/pubmed/18162508 .. _PMID 20142250: http://www.ncbi.nlm.nih.gov/pubmed/20142250 .. _PMID 21422097: http://www.ncbi.nlm.nih.gov/pubmed/21422097 .. _IGF2BP2 Pubmed: PubMed Articles *************** *Recent articles:* * Tsai YC et al. "Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcription." Mol Cell Proteomics. 2012 May;11(5):60-76. `PMID 22586326`_ * Perry JR et al. "Stratifying type 2 diabetes cases by BMI identifies genetic risk variants in LAMA1 and enrichment for risk variants in lean compared to obese cases." PLoS Genet. 2012 May;8(5):e1002741. `PMID 22693455`_ * Zhao Y et al. "IGF2BP2 genetic variation and type 2 diabetes: a global meta-analysis." DNA Cell Biol. 2012 May;31(5):713-20. `PMID 22032244`_ * Le HT et al. "Two isoforms of the mRNA binding protein IGF2BP2 are generated by alternative translational initiation." PLoS One. 2012;7(3):e33140. `PMID 22427968`_ * Kwak SH et al. "A genome-wide association study of gestational diabetes mellitus in Korean women." Diabetes. 2012 Feb;61(2):531-41. `PMID 22233651`_ * Wang Y et al. "Association of six single nucleotide polymorphisms with gestational diabetes mellitus in a Chinese population." PLoS One. 2011;6(11):e26953. `PMID 22096510`_ * Kim W et al. "Systematic and quantitative assessment of the ubiquitin-modified proteome." Mol Cell. 2011 Oct 21;44(2):325-40. `PMID 21906983`_ * Wagner SA et al. "A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles." Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. `PMID 21890473`_ * Watanabe Y et al. "p62/SQSTM1 in autophagic clearance of a non-ubiquitylated substrate." J Cell Sci. 2011 Aug 15;124(Pt 16):2692-701. `PMID 21771882`_ * Jia H et al. "Association between IGF2BP2 rs4402960 polymorphism and risk of type 2 diabetes mellitus: a meta-analysis." Arch Med Res. 2011 Jul;42(5):361-7. `PMID 21839790`_ .. _PMID 21890473: http://www.ncbi.nlm.nih.gov/pubmed/21890473 .. _PMID 22233651: http://www.ncbi.nlm.nih.gov/pubmed/22233651 .. _PMID 22586326: http://www.ncbi.nlm.nih.gov/pubmed/22586326 .. _PMID 21771882: http://www.ncbi.nlm.nih.gov/pubmed/21771882 .. _PMID 21839790: http://www.ncbi.nlm.nih.gov/pubmed/21839790 .. _PMID 22427968: http://www.ncbi.nlm.nih.gov/pubmed/22427968 .. _PMID 22096510: http://www.ncbi.nlm.nih.gov/pubmed/22096510 .. _PMID 22693455: http://www.ncbi.nlm.nih.gov/pubmed/22693455 .. _PMID 21906983: http://www.ncbi.nlm.nih.gov/pubmed/21906983 .. _PMID 22032244: http://www.ncbi.nlm.nih.gov/pubmed/22032244 *Top Pubmed articles linked to gene IGF2BP2 matching any search term:* * Iwata M et al. "Genetic risk score constructed using 14 susceptibility alleles for type 2 diabetes is associated with the early onset of diabetes and may predict the future requirement of insulin injections among Japanese individuals." Diabetes Care. 2012 Aug;35(8):1763-70. `PMID 22688542`_ * Jia H et al. "Reply: Clarification of Data in the Recent Meta-analysis About Association Between IGF2BP2 rs4402960 Polymorphism And Risk of Type 2 Diabetes Mellitus." Arch Med Res. 2012 Jul 24;. `PMID 22841982`_ * Liu S et al. "Association Between IGF2BP2 rs4402960 Polymorphism And Risk of Type 2 Diabetes Mellitus: Need for Clarification of Data in a Recent Meta-analysis." Arch Med Res. 2012 Jul 23;. `PMID 22835599`_ * Gu T et al. "IGF2BP2 and IGF2 genetic effects in diabetes and diabetic nephropathy." J Diabetes Complications. 2012 Jul 4;. `PMID 22770937`_ * Schaeffer V et al. "RNA-binding protein IGF2BP2/IMP2 is required for laminin-β2 mRNA translation and is modulated by glucose concentration." Am J Physiol Renal Physiol. 2012 Jul;303(1):F75-82. `PMID 22513850`_ * Mtiraoui N et al. "Contribution of common variants of ENPP1, IGF2BP2, KCNJ11, MLXIPL, PPARγ, SLC30A8 and TCF7L2 to the risk of type 2 diabetes in Lebanese and Tunisian Arabs." Diabetes Metab. 2012 Jun 27;. `PMID 22749234`_ * Ekelund M et al. "Genetic prediction of postpartum diabetes in women with gestational diabetes mellitus." Diabetes Res Clin Pract. 2012 May 14;. `PMID 22591707`_ * Kurzawski M et al. "Analysis of common type 2 diabetes mellitus genetic risk factors in new-onset diabetes after transplantation in kidney transplant patients medicated with tacrolimus." Eur J Clin Pharmacol. 2012 May 9;. `PMID 22569928`_ * Perry JR et al. "Stratifying type 2 diabetes cases by BMI identifies genetic risk variants in LAMA1 and enrichment for risk variants in lean compared to obese cases." PLoS Genet. 2012 May;8(5):e1002741. `PMID 22693455`_ * Winkler C et al. "Lack of association of type 2 diabetes susceptibility genotypes and body weight on the development of islet autoimmunity and type 1 diabetes." PLoS One. 2012;7(4):e35410. `PMID 22558147`_ * Cauchi S et al. "European genetic variants associated with type 2 diabetes in North African Arabs." Diabetes Metab. 2012 Mar 29;. `PMID 22463974`_ * Wang Y et al. "Association of six single nucleotide polymorphisms with gestational diabetes mellitus in a Chinese population." PLoS One. 2011;6(11):e26953. `PMID 22096510`_ * Boudoukha S et al. "Role of the RNA-binding protein IMP-2 in muscle cell motility." Mol Cell Biol. 2010 Dec;30(24):5710-25. `PMID 20956565`_ * Rotger M et al. "Impact of single nucleotide polymorphisms and of clinical risk factors on new‐onset diabetes mellitus in HIV‐infected individuals." Clin Infect Dis. 2010 Nov 1;51(9):1090-8. `PMID 20879858`_ * Bailey SD et al. "Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study." Diabetes Care. 2010 Oct;33(10):2250-3. `PMID 20628086`_ * Stuebe AM et al. "Obesity and diabetes genetic variants associated with gestational weight gain." Am J Obstet Gynecol. 2010 Sep;203(3):283.e1-17. `PMID 20816152`_ * Pechlivanis S et al. "Coronary artery calcification and its relationship to validated genetic variants for diabetes mellitus assessed in the Heinz Nixdorf recall cohort." Arterioscler Thromb Vasc Biol. 2010 Sep;30(9):1867-72. `PMID 20616309`_ * Ruchat SM et al. "Improvements in glucose homeostasis in response to regular exercise are influenced by the PPARG Pro12Ala variant: results from the HERITAGE Family Study." Diabetologia. 2010 Apr;53(4):679-89. `PMID 20043145`_ * Schulze MB et al. "Use of multiple metabolic and genetic markers to improve the prediction of type 2 diabetes: the EPIC-Potsdam Study." Diabetes Care. 2009 Nov;32(11):2116-9. `PMID 19720844`_ * Grarup N et al. "Studies of association of variants near the HHEX, CDKN2A/B, and IGF2BP2 genes with type 2 diabetes and impaired insulin release in 10,705 Danish subjects: validation and extension of genome-wide association studies." Diabetes. 2007 Dec;56(12):3105-11. `PMID 17827400`_ .. _PMID 22841982: http://www.ncbi.nlm.nih.gov/pubmed/22841982 .. _PMID 19720844: http://www.ncbi.nlm.nih.gov/pubmed/19720844 .. _PMID 22770937: http://www.ncbi.nlm.nih.gov/pubmed/22770937 .. _PMID 20816152: http://www.ncbi.nlm.nih.gov/pubmed/20816152 .. _PMID 22096510: http://www.ncbi.nlm.nih.gov/pubmed/22096510 .. _PMID 22688542: http://www.ncbi.nlm.nih.gov/pubmed/22688542 .. _PMID 22558147: http://www.ncbi.nlm.nih.gov/pubmed/22558147 .. _PMID 22463974: http://www.ncbi.nlm.nih.gov/pubmed/22463974 .. _PMID 20628086: http://www.ncbi.nlm.nih.gov/pubmed/20628086 .. _PMID 20616309: http://www.ncbi.nlm.nih.gov/pubmed/20616309 .. _PMID 22591707: http://www.ncbi.nlm.nih.gov/pubmed/22591707 .. _PMID 17827400: http://www.ncbi.nlm.nih.gov/pubmed/17827400 .. _PMID 22569928: http://www.ncbi.nlm.nih.gov/pubmed/22569928 .. _PMID 22749234: http://www.ncbi.nlm.nih.gov/pubmed/22749234 .. _PMID 22513850: http://www.ncbi.nlm.nih.gov/pubmed/22513850 .. _PMID 20043145: http://www.ncbi.nlm.nih.gov/pubmed/20043145 .. _PMID 20956565: http://www.ncbi.nlm.nih.gov/pubmed/20956565 .. _PMID 22835599: http://www.ncbi.nlm.nih.gov/pubmed/22835599 .. _PMID 20879858: http://www.ncbi.nlm.nih.gov/pubmed/20879858 .. _PMID 22693455: http://www.ncbi.nlm.nih.gov/pubmed/22693455