.. _IL34:

IL34
^^^^

.. contents::
   :local:

General Information
*******************

:Full gene name: interleukin 34
:Entrez Gene ID: 146433
:Location: 16q22.1
:Synonyms: IL-34, C16orf77
:Type: protein-coding

eQTLs
*****

This gene is a target of the following eQTL associations:

+-----------+-----------------+--------+------------+--------------+---------+--------+
|    eQTL   |       Gene      | Tissue | Population |   Organism   | P-value | Source |
+===========+=================+========+============+==============+=========+========+
| rs7957197 | :ref:`C16orf77` | LCL    | YRI        | Homo sapiens | 3e-06   | SCAN   |
+-----------+-----------------+--------+------------+--------------+---------+--------+

.. _IL34 Gene summary:

NCBI Summary
************

Interleukin-34 is a cytokine that promotes the differentiation and viability of monocytes and macrophages through the colony-stimulating factor-1 receptor (CSF1R; MIM 164770) (Lin et al., 2008 [PubMed 18467591]).[supplied by OMIM, May 2008]

.. _OMIM ID 612081
                        : http://omim.org/entry/612081
                        

.. _IL34 OMIM Text:

OMIM
****

:OMIM ID: `OMIM ID 612081
                        `_


.. _IL34 Phenotype:

NCBI Phenotypes
***************

No phenotypes found linked to this gene.

.. _IL34 GO Term:

Gene Ontology
*************

* innate immune response
* extracellular space
* inflammatory response
* cytokine activity
* positive regulation of protein phosphorylation
* positive regulation of cell proliferation
* macrophage colony-stimulating factor receptor binding
* growth factor activity

.. _IL34 Pathway:

KEGG Pathways
*************

No pathways found linked to this gene.

.. _IL34 GeneRIF:

GeneRIFs
********

* study identifies IL-34 expression in the synovial tissue of patients with arthritis; this cytokine, as a downstream effector of TNFalpha and IL-1beta, may contribute to inflammation and bone erosions in rheumatoid arthritis [`PMID 22039170`_]
* The different spatiotemporal expression of IL-34 and CSF-1 allows for complementary activation of the CSF-1R in developing and adult tissues. [`PMID 20504948`_]
* Discovered IL-34 and its receptor CSF1 by functional screening of the extracellular proteome. [`PMID 18467591`_]

.. _PMID 22039170: http://www.ncbi.nlm.nih.gov/pubmed/22039170
.. _PMID 20504948: http://www.ncbi.nlm.nih.gov/pubmed/20504948
.. _PMID 18467591: http://www.ncbi.nlm.nih.gov/pubmed/18467591

.. _IL34 Pubmed:

PubMed Articles
***************

*Recent articles:*

* Chemel M et al. "Interleukin 34 expression is associated with synovitis severity in rheumatoid arthritis patients." Ann Rheum Dis. 2012 Jan;71(1):150-4. `PMID 22039170`_
* Wei S et al. "Functional overlap but differential expression of CSF-1 and IL-34 in their CSF-1 receptor-mediated regulation of myeloid cells." J Leukoc Biol. 2010 Sep;88(3):495-505. `PMID 20504948`_
* Lin H et al. "Discovery of a cytokine and its receptor by functional screening of the extracellular proteome." Science. 2008 May 9;320(5877):807-11. `PMID 18467591`_
* Lim J et al. "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration." Cell. 2006 May 19;125(4):801-14. `PMID 16713569`_
* Strausberg RL et al. "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences." Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. `PMID 12477932`_

.. _PMID 22039170: http://www.ncbi.nlm.nih.gov/pubmed/22039170
.. _PMID 16713569: http://www.ncbi.nlm.nih.gov/pubmed/16713569
.. _PMID 20504948: http://www.ncbi.nlm.nih.gov/pubmed/20504948
.. _PMID 12477932: http://www.ncbi.nlm.nih.gov/pubmed/12477932
.. _PMID 18467591: http://www.ncbi.nlm.nih.gov/pubmed/18467591

*Top Pubmed articles linked to gene IL34 matching any search term:* 

* Below JE et al. "Genome-wide association and meta-analysis in populations from Starr County, Texas, and Mexico City identify type 2 diabetes susceptibility loci and enrichment for expression quantitative trait loci in top signals." Diabetologia. 2011 Aug;54(8):2047-55. `PMID 21647700`_

.. _PMID 21647700: http://www.ncbi.nlm.nih.gov/pubmed/21647700