.. _INTS8:

INTS8
^^^^^

.. contents::
   :local:

General Information
*******************

:Full gene name: integrator complex subunit 8
:Entrez Gene ID: 55656
:Location: 8q22.1
:Synonyms: INT8, C8orf52
:Type: protein-coding

User SNPs
*********

SNPs given by the user that are near or inside this gene: 

+----------+---------------+------------+
|   SNP    | Distance (bp) | Direction  |
+==========+===============+============+
| rs896854 |     67790     | downstream |
+----------+---------------+------------+

.. _INTS8 Gene summary:

NCBI Summary
************

INTS8 is a subunit of the Integrator complex, which associates with the C-terminal domain of RNA polymerase II large subunit (POLR2A; MIM 180660) and mediates 3-prime end processing of small nuclear RNAs U1 (RNU1; MIM 180680) and U2 (RNU2; MIM 180690) (Baillat et al., 2005 [PubMed 16239144]).[supplied by OMIM, Mar 2008]

.. _OMIM ID 611351
                        : http://omim.org/entry/611351
                        

.. _INTS8 OMIM Text:

OMIM
****

:OMIM ID: `OMIM ID 611351
                        `_


.. _INTS8 Phenotype:

NCBI Phenotypes
***************

No phenotypes found linked to this gene.

.. _INTS8 GO Term:

Gene Ontology
*************

* integrator complex
* protein binding
* snRNA processing

.. _INTS8 Pathway:

KEGG Pathways
*************

No pathways found linked to this gene.

.. _INTS8 GeneRIF:

GeneRIFs
********

* Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator) [`PMID 20379614`_]
* Affinity Capture-MS [`PMID 21906983`_]
* Affinity Capture-MS [`PMID 20133760`_]
* Affinity Capture-MS [`PMID 20133760`_]
* Affinity Capture-MS [`PMID 20133760`_]
* Affinity Capture-MS [`PMID 20133760`_]
* Affinity Capture-MS [`PMID 16239144`_]
* Reconstituted Complex [`PMID 16239144`_]
* Affinity Capture-MS [`PMID 16239144`_]

.. _PMID 20379614: http://www.ncbi.nlm.nih.gov/pubmed/20379614
.. _PMID 21906983: http://www.ncbi.nlm.nih.gov/pubmed/21906983
.. _PMID 20133760: http://www.ncbi.nlm.nih.gov/pubmed/20133760
.. _PMID 16239144: http://www.ncbi.nlm.nih.gov/pubmed/16239144

.. _INTS8 Pubmed:

PubMed Articles
***************

*Recent articles:*

* Kim W et al. "Systematic and quantitative assessment of the ubiquitin-modified proteome." Mol Cell. 2011 Oct 21;44(2):325-40. `PMID 21906983`_
* Danielsen JM et al. "Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level." Mol Cell Proteomics. 2011 Mar;10(3):M110.003590. `PMID 21139048`_
* Rose JE et al. "Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score." Mol Med. 2010 Jul-Aug;16(7-8):247-53. `PMID 20379614`_
* Malovannaya A et al. "Streamlined analysis schema for high-throughput identification of endogenous protein complexes." Proc Natl Acad Sci U S A. 2010 Feb 9;107(6):2431-6. `PMID 20133760`_
* Olsen JV et al. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks." Cell. 2006 Nov 3;127(3):635-48. `PMID 17081983`_
* Baillat D et al. "Integrator, a multiprotein mediator of small nuclear RNA processing, associates with the C-terminal repeat of RNA polymerase II." Cell. 2005 Oct 21;123(2):265-76. `PMID 16239144`_
* Gerhard DS et al. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." Genome Res. 2004 Oct;14(10B):2121-7. `PMID 15489334`_
* Ota T et al. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat Genet. 2004 Jan;36(1):40-5. `PMID 14702039`_
* Strausberg RL et al. "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences." Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. `PMID 12477932`_
* Hillier LD et al. "Generation and analysis of 280,000 human expressed sequence tags." Genome Res. 1996 Sep;6(9):807-28. `PMID 8889549`_

.. _PMID 17081983: http://www.ncbi.nlm.nih.gov/pubmed/17081983
.. _PMID 16239144: http://www.ncbi.nlm.nih.gov/pubmed/16239144
.. _PMID 14702039: http://www.ncbi.nlm.nih.gov/pubmed/14702039
.. _PMID 8889549: http://www.ncbi.nlm.nih.gov/pubmed/8889549
.. _PMID 12477932: http://www.ncbi.nlm.nih.gov/pubmed/12477932
.. _PMID 21139048: http://www.ncbi.nlm.nih.gov/pubmed/21139048
.. _PMID 20379614: http://www.ncbi.nlm.nih.gov/pubmed/20379614
.. _PMID 20133760: http://www.ncbi.nlm.nih.gov/pubmed/20133760
.. _PMID 21906983: http://www.ncbi.nlm.nih.gov/pubmed/21906983
.. _PMID 15489334: http://www.ncbi.nlm.nih.gov/pubmed/15489334