.. _JAKMIP1:

JAKMIP1
^^^^^^^

.. contents::
   :local:

General Information
*******************

:Full gene name: janus kinase and microtubule interacting protein 1
:Entrez Gene ID: 152789
:Location: 4p16.1
:Synonyms: Gababrbp, MARLIN1, JAMIP1
:Type: protein-coding

User SNPs
*********

SNPs given by the user that are near or inside this gene: 

+------------+---------------+-----------+
|    SNP     | Distance (bp) | Direction |
+============+===============+===========+
| rs10010131 |     90597     |  upstream |
+------------+---------------+-----------+

.. _JAKMIP1 Gene summary:

NCBI Summary
************

None available.

.. _OMIM ID 611195
                        : http://omim.org/entry/611195
                        

.. _JAKMIP1 OMIM Text:

OMIM
****

:OMIM ID: `OMIM ID 611195
                        `_


.. _JAKMIP1 Phenotype:

NCBI Phenotypes
***************

* NHGRI GWA Catalog
* Genomic association analysis identifies multiple loci influencing antihypertensive response to an angiotensin II receptor blocker.

.. _JAKMIP1 GO Term:

Gene Ontology
*************

* ribonucleoprotein complex
* microtubule
* RNA binding
* GABA receptor binding
* extrinsic to membrane
* cytoplasm
* protein transport
* kinase binding
* microtubule binding

.. _JAKMIP1 Pathway:

KEGG Pathways
*************

No pathways found linked to this gene.

.. _JAKMIP1 GeneRIF:

GeneRIFs
********

* Marlin-1 functions to regulate the cellular levels of GABA(B) R2 subunits, which may have significant effects on the production of functional GABA(B) receptor heterodimers [`PMID 14718537`_]
* Affinity Capture-Western; Reconstituted Complex [`PMID 14718537`_]
* We have identified four new transcripts of 2975 bp, 1743 bp, 2189 bp and 2420 bp respectively, named Jakmip1B, Jakmip1C, Jakmip1D and Jakmip1E [`PMID 17761393`_]
* Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator) [`PMID 20379614`_]
* Observational study of gene-disease association. (HuGE Navigator) [`PMID 17804789`_]
* Marlin1 has a role in cell polarization, segregation of signaling complexes, and vesicle traffic, some of which may involve Jak tyrosine kinases [`PMID 15277531`_]
* Jamip1 interacts with Tyk2. [`PMID 15277531`_]
* Jamip1 interacts with Jamip1. [`PMID 15277531`_]
* Jamip1 interacts with Jak1. [`PMID 15277531`_]
* Jakmip1 is a novel effector memory gene that restrains T cell-mediated cytotoxicity. [`PMID 18941173`_]

.. _PMID 14718537: http://www.ncbi.nlm.nih.gov/pubmed/14718537
.. _PMID 17761393: http://www.ncbi.nlm.nih.gov/pubmed/17761393
.. _PMID 20379614: http://www.ncbi.nlm.nih.gov/pubmed/20379614
.. _PMID 17804789: http://www.ncbi.nlm.nih.gov/pubmed/17804789
.. _PMID 15277531: http://www.ncbi.nlm.nih.gov/pubmed/15277531
.. _PMID 18941173: http://www.ncbi.nlm.nih.gov/pubmed/18941173

.. _JAKMIP1 Pubmed:

PubMed Articles
***************

*Recent articles:*

* Turner ST et al. "Genomic association analysis identifies multiple loci influencing antihypertensive response to an angiotensin II receptor blocker." Hypertension. 2012 Jun;59(6):1204-11. `PMID 22566498`_
* Rose JE et al. "Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score." Mol Med. 2010 Jul-Aug;16(7-8):247-53. `PMID 20379614`_
* Libri V et al. "Jakmip1 is expressed upon T cell differentiation and has an inhibitory function in cytotoxic T lymphocytes." J Immunol. 2008 Nov 1;181(9):5847-56. `PMID 18941173`_
* Costa V et al. "Identification and expression analysis of novel Jakmip1 transcripts." Gene. 2007 Nov 1;402(1-2):1-8. `PMID 17761393`_
* Raelson JV et al. "Genome-wide association study for Crohn's disease in the Quebec Founder Population identifies multiple validated disease loci." Proc Natl Acad Sci U S A. 2007 Sep 11;104(37):14747-52. `PMID 17804789`_
* Cruz-Garcia D et al. "Identification and characterization of two novel (neuro)endocrine long coiled-coil proteins." FEBS Lett. 2007 Jul 10;581(17):3149-56. `PMID 17572408`_
* Kimura K et al. "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes." Genome Res. 2006 Jan;16(1):55-65. `PMID 16344560`_
* Steindler C et al. "Jamip1 (marlin-1) defines a family of proteins interacting with janus kinases and microtubules." J Biol Chem. 2004 Oct 8;279(41):43168-77. `PMID 15277531`_
* Jin J et al. "Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization." Curr Biol. 2004 Aug 24;14(16):1436-50. `PMID 15324660`_
* Couve A et al. "Marlin-1, a novel RNA-binding protein associates with GABA receptors." J Biol Chem. 2004 Apr 2;279(14):13934-43. `PMID 14718537`_

.. _PMID 14718537: http://www.ncbi.nlm.nih.gov/pubmed/14718537
.. _PMID 22566498: http://www.ncbi.nlm.nih.gov/pubmed/22566498
.. _PMID 17804789: http://www.ncbi.nlm.nih.gov/pubmed/17804789
.. _PMID 15324660: http://www.ncbi.nlm.nih.gov/pubmed/15324660
.. _PMID 15277531: http://www.ncbi.nlm.nih.gov/pubmed/15277531
.. _PMID 20379614: http://www.ncbi.nlm.nih.gov/pubmed/20379614
.. _PMID 17572408: http://www.ncbi.nlm.nih.gov/pubmed/17572408
.. _PMID 17761393: http://www.ncbi.nlm.nih.gov/pubmed/17761393
.. _PMID 18941173: http://www.ncbi.nlm.nih.gov/pubmed/18941173
.. _PMID 16344560: http://www.ncbi.nlm.nih.gov/pubmed/16344560