.. _KLF14: KLF14 ^^^^^ .. contents:: :local: General Information ******************* :Full gene name: Kruppel-like factor 14 :Entrez Gene ID: 136259 :Location: 7q32.3 :Synonyms: BTEB5 :Type: protein-coding User SNPs ********* SNPs given by the user that are near or inside this gene: +----------+---------------+-----------+ | SNP | Distance (bp) | Direction | +==========+===============+===========+ | rs972283 | 47966 | upstream | +----------+---------------+-----------+ .. _KLF14 Gene summary: NCBI Summary ************ This gene encodes a member of the Kruppel-like family of transcription factors. The gene exhibits imprinted expression from the maternal allele in embryonic and extra-embryonic tissues. Expression of this gene is induced by TGF-beta, and the protein represses TGF-beta receptor II expression. The protein functions as part of a transcriptional co-repressor complex that also contains the transcriptional regulator SIN3A and histone deacetylase 2. [provided by RefSeq, Nov 2009] .. _OMIM ID 608613 : http://omim.org/entry/608613 .. _KLF14 OMIM Text: OMIM **** :OMIM ID: `OMIM ID 608613 `_ .. _KLF14 Phenotype: NCBI Phenotypes *************** * Biological, clinical and population relevance of 95 loci for blood lipids. * Twelve type 2 \ ``diabetes``\ susceptibility loci identified through large-scale association analysis. * NHGRI GWA Catalog .. _KLF14 GO Term: Gene Ontology ************* * DNA binding * nucleus * transcription, DNA-dependent * regulation of transcription, DNA-dependent * zinc ion binding .. _KLF14 Pathway: KEGG Pathways ************* No pathways found linked to this gene. .. _KLF14 GeneRIF: GeneRIFs ******** * Observational study of gene-disease association, gene-gene interaction, and gene-environment interaction. (HuGE Navigator) [`PMID 20889853`_] * Observational study and genome-wide association study of gene-disease association. (HuGE Navigator) [`PMID 19936222`_] * Observational study of gene-disease association. (HuGE Navigator) [`PMID 19578363`_] * KLF14 gene is imprinted, with preferential expression from the maternal allele. [`PMID 17480121`_] * we show that the type 2 \ ``diabetes``\ and high-density lipoprotein cholesterol-associated cis-acting expression quantitative trait locus (eQTL) of the maternally expressed transcription factor KLF14 acts as a master trans regulator of adipose gene expression [`PMID 21572415`_] * Affinity Capture-MS [`PMID 21906983`_] * the TGFbeta pathway activation leads to recruitment of a KLF14-mSin3A-HDAC2 repressor complex to the TGFbetaRII promoter, as well as the remodeling of chromatin to increase histone marks that associate with transcriptional silencing. [`PMID 19088080`_] .. _PMID 20889853: http://www.ncbi.nlm.nih.gov/pubmed/20889853 .. _PMID 19936222: http://www.ncbi.nlm.nih.gov/pubmed/19936222 .. _PMID 19578363: http://www.ncbi.nlm.nih.gov/pubmed/19578363 .. _PMID 17480121: http://www.ncbi.nlm.nih.gov/pubmed/17480121 .. _PMID 21572415: http://www.ncbi.nlm.nih.gov/pubmed/21572415 .. _PMID 21906983: http://www.ncbi.nlm.nih.gov/pubmed/21906983 .. _PMID 19088080: http://www.ncbi.nlm.nih.gov/pubmed/19088080 .. _KLF14 Pubmed: PubMed Articles *************** *Recent articles:* * Kim W et al. "Systematic and quantitative assessment of the ubiquitin-modified proteome." Mol Cell. 2011 Oct 21;44(2):325-40. `PMID 21906983`_ * Small KS et al. "Identification of an imprinted master trans regulator at the KLF14 locus related to multiple metabolic phenotypes." Nat Genet. 2011 Jun;43(6):561-4. `PMID 21572415`_ * de Miguel-Yanes JM et al. "Genetic risk reclassification for type 2 diabetes by age below or above 50 years using 40 type 2 diabetes risk single nucleotide polymorphisms." Diabetes Care. 2011 Jan;34(1):121-5. `PMID 20889853`_ * Teslovich TM et al. "Biological, clinical and population relevance of 95 loci for blood lipids." Nature. 2010 Aug 5;466(7307):707-13. `PMID 20686565`_ * Voight BF et al. "Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis." Nat Genet. 2010 Jul;42(7):579-89. `PMID 20581827`_ * Chasman DI et al. "Forty-three loci associated with plasma lipoprotein size, concentration, and cholesterol content in genome-wide analysis." PLoS Genet. 2009 Nov;5(11):e1000730. `PMID 19936222`_ * Stacey SN et al. "New common variants affecting susceptibility to basal cell carcinoma." Nat Genet. 2009 Aug;41(8):909-14. `PMID 19578363`_ * Truty MJ et al. "Silencing of the transforming growth factor-beta (TGFbeta) receptor II by Kruppel-like factor 14 underscores the importance of a negative feedback mechanism in TGFbeta signaling." J Biol Chem. 2009 Mar 6;284(10):6291-300. `PMID 19088080`_ * Parker-Katiraee L et al. "Identification of the imprinted KLF14 transcription factor undergoing human-specific accelerated evolution." PLoS Genet. 2007 May 4;3(5):e65. `PMID 17480121`_ * Suske G et al. "Mammalian SP/KLF transcription factors: bring in the family." Genomics. 2005 May;85(5):551-6. `PMID 15820306`_ .. _PMID 20889853: http://www.ncbi.nlm.nih.gov/pubmed/20889853 .. _PMID 19936222: http://www.ncbi.nlm.nih.gov/pubmed/19936222 .. _PMID 15820306: http://www.ncbi.nlm.nih.gov/pubmed/15820306 .. _PMID 20581827: http://www.ncbi.nlm.nih.gov/pubmed/20581827 .. _PMID 19578363: http://www.ncbi.nlm.nih.gov/pubmed/19578363 .. _PMID 20686565: http://www.ncbi.nlm.nih.gov/pubmed/20686565 .. _PMID 19088080: http://www.ncbi.nlm.nih.gov/pubmed/19088080 .. _PMID 21572415: http://www.ncbi.nlm.nih.gov/pubmed/21572415 .. _PMID 21906983: http://www.ncbi.nlm.nih.gov/pubmed/21906983 .. _PMID 17480121: http://www.ncbi.nlm.nih.gov/pubmed/17480121 *Top Pubmed articles linked to gene KLF14 matching any search term:* * Chen G et al. "Genome-wide association study identifies novel loci association with fasting insulin and insulin resistance in African Americans." Hum Mol Genet. 2012 Jul 30;. `PMID 22791750`_ * Ohshige T et al. "Association of new loci identified in European genome-wide association studies with susceptibility to type 2 diabetes in the Japanese." PLoS One. 2011;6(10):e26911. `PMID 22046406`_ * Zhang J et al. "Regulation of fat storage and reproduction by Krüppel-like transcription factor KLF3 and fat-associated genes in Caenorhabditis elegans." J Mol Biol. 2011 Aug 19;411(3):537-53. `PMID 21704635`_ * Rees SD et al. "Replication of 13 genome-wide association (GWA)-validated risk variants for type 2 diabetes in Pakistani populations." Diabetologia. 2011 Jun;54(6):1368-74. `PMID 21350842`_ * Small KS et al. "Identification of an imprinted master trans regulator at the KLF14 locus related to multiple metabolic phenotypes." Nat Genet. 2011 Jun;43(6):561-4. `PMID 21572415`_ * Nielsen T et al. "Type 2 diabetes risk allele near CENTD2 is associated with decreased glucose-stimulated insulin release." Diabetologia. 2011 May;54(5):1052-6. `PMID 21267535`_ * de Miguel-Yanes JM et al. "Genetic risk reclassification for type 2 diabetes by age below or above 50 years using 40 type 2 diabetes risk single nucleotide polymorphisms." Diabetes Care. 2011 Jan;34(1):121-5. `PMID 20889853`_ * Voight BF et al. "Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis." Nat Genet. 2010 Jul;42(7):579-89. `PMID 20581827`_ .. _PMID 20889853: http://www.ncbi.nlm.nih.gov/pubmed/20889853 .. _PMID 22791750: http://www.ncbi.nlm.nih.gov/pubmed/22791750 .. _PMID 21267535: http://www.ncbi.nlm.nih.gov/pubmed/21267535 .. _PMID 22046406: http://www.ncbi.nlm.nih.gov/pubmed/22046406 .. _PMID 21350842: http://www.ncbi.nlm.nih.gov/pubmed/21350842 .. _PMID 20581827: http://www.ncbi.nlm.nih.gov/pubmed/20581827 .. _PMID 21704635: http://www.ncbi.nlm.nih.gov/pubmed/21704635 .. _PMID 21572415: http://www.ncbi.nlm.nih.gov/pubmed/21572415