.. _MAN2A2: MAN2A2 ^^^^^^ .. contents:: :local: General Information ******************* :Full gene name: mannosidase, alpha, class 2A, member 2 :Entrez Gene ID: 4122 :Location: 15q26.1 :Synonyms: MANA2X :Type: protein-coding User SNPs ********* SNPs given by the user that are near or inside this gene: +-----------+---------------+------------+ | SNP | Distance (bp) | Direction | +===========+===============+============+ | rs8042680 | 55522 | downstream | +-----------+---------------+------------+ .. _MAN2A2 Gene summary: NCBI Summary ************ None available. .. _OMIM ID 600988 : http://omim.org/entry/600988 .. _MAN2A2 OMIM Text: OMIM **** :OMIM ID: `OMIM ID 600988 `_ .. _MAN2A2 Phenotype: NCBI Phenotypes *************** * NHGRI GWA Catalog * Molecular genetics of adult ADHD: converging evidence from genome-wide association and extended pedigree linkage studies. .. _MAN2A2 GO Term: Gene Ontology ************* * carbohydrate binding * cellular protein metabolic process * carbohydrate metabolic process * zinc ion binding * protein N-linked glycosylation via asparagine * mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase activity * integral to membrane * post-translational protein modification * Golgi membrane * mannose metabolic process .. _MAN2A2 Pathway: KEGG Pathways ************* * `N-Glycan biosynthesis `_ * `Metabolic pathways `_ .. _MAN2A2 GeneRIF: GeneRIFs ******** * Specific alterations of the N-linked carbohydrates on HIV-1 gp120 and gp41 by glucosidases and mannosidase inhibitors can enhance mannose-binding lectin (MBL)-mediated neutralization of virus by strengthening the interaction of HIV-1 with MBL [`PMID 12560567`_] * Oligosaccharide side-chains of HIV-1 gp160 are processed by glycosidase I and II, mannosidase I and II, acetylglucosaminyl transferase I and II, and fucosyl, galactosyl and sialyl transferases in both the endoplasmic reticulum and golgi apparatus [`PMID 11530211`_] * Two-hybrid [`PMID 16169070`_] * Two-hybrid [`PMID 16169070`_] * Two-hybrid [`PMID 16169070`_] * Two-hybrid [`PMID 16169070`_] * Two-hybrid [`PMID 16169070`_] * Mannose-containing, N-linked oligosaccharide side-chains of HIV-1 gp41 are involved in the initial stage of infection by HIV-1; glycosylation inhibitors block virus-cell and cell-cell fusion and release of the virions [`PMID 8093218`_] * HIV-1 gp120 N-linked oligosaccharides are processed by manosidase I and II in the Golgi complex [`PMID 8892864`_] .. _PMID 12560567: http://www.ncbi.nlm.nih.gov/pubmed/12560567 .. _PMID 11530211: http://www.ncbi.nlm.nih.gov/pubmed/11530211 .. _PMID 16169070: http://www.ncbi.nlm.nih.gov/pubmed/16169070 .. _PMID 8093218: http://www.ncbi.nlm.nih.gov/pubmed/8093218 .. _PMID 8892864: http://www.ncbi.nlm.nih.gov/pubmed/8892864 .. _MAN2A2 Pubmed: PubMed Articles *************** *Recent articles:* * Lesch KP et al. "Molecular genetics of adult ADHD: converging evidence from genome-wide association and extended pedigree linkage studies." J Neural Transm. 2008 Nov;115(11):1573-85. `PMID 18839057`_ * Stelzl U et al. "A human protein-protein interaction network: a resource for annotating the proteome." Cell. 2005 Sep 23;122(6):957-68. `PMID 16169070`_ * Hillman RT et al. "An unappreciated role for RNA surveillance." Genome Biol. 2004;5(2):R8. `PMID 14759258`_ * Hart ML et al. "Glycosylation inhibitors and neuraminidase enhance human immunodeficiency virus type 1 binding and neutralization by mannose-binding lectin." J Gen Virol. 2003 Feb;84(Pt 2):353-60. `PMID 12560567`_ * Strausberg RL et al. "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences." Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. `PMID 12477932`_ * Land A et al. "Folding of the human immunodeficiency virus type 1 envelope glycoprotein in the endoplasmic reticulum." Biochimie. 2001 Aug;83(8):783-90. `PMID 11530211`_ * Papandreou MJ et al. "Effect of various glycosidase treatments on the resistance of the HIV-1 envelope to degradation." FEBS Lett. 1997 Apr 7;406(1-2):191-5. `PMID 9109416`_ * Hu H et al. "Infectivities of human and other primate lentiviruses are activated by desialylation of the virion surface." J Virol. 1996 Nov;70(11):7462-70. `PMID 8892864`_ * Bolmstedt A et al. "Influence of N-linked glycans in V4-V5 region of human immunodeficiency virus type 1 glycoprotein gp160 on induction of a virus-neutralizing humoral response." J Acquir Immune Defic Syndr Hum Retrovirol. 1996 Jul;12(3):213-20. `PMID 8673525`_ * Misago M et al. "Molecular cloning and expression of cDNAs encoding human alpha-mannosidase II and a previously unrecognized alpha-mannosidase IIx isozyme." Proc Natl Acad Sci U S A. 1995 Dec 5;92(25):11766-70. `PMID 8524845`_ .. _PMID 9109416: http://www.ncbi.nlm.nih.gov/pubmed/9109416 .. _PMID 8673525: http://www.ncbi.nlm.nih.gov/pubmed/8673525 .. _PMID 18839057: http://www.ncbi.nlm.nih.gov/pubmed/18839057 .. _PMID 12477932: http://www.ncbi.nlm.nih.gov/pubmed/12477932 .. _PMID 8892864: http://www.ncbi.nlm.nih.gov/pubmed/8892864 .. _PMID 12560567: http://www.ncbi.nlm.nih.gov/pubmed/12560567 .. _PMID 11530211: http://www.ncbi.nlm.nih.gov/pubmed/11530211 .. _PMID 14759258: http://www.ncbi.nlm.nih.gov/pubmed/14759258 .. _PMID 16169070: http://www.ncbi.nlm.nih.gov/pubmed/16169070 .. _PMID 8524845: http://www.ncbi.nlm.nih.gov/pubmed/8524845 *Top Pubmed articles linked to gene MAN2A2 matching any search term:* * Pal R et al. "Role of oligosaccharides in the processing and maturation of envelope glycoproteins of human immunodeficiency virus type 1." Proc Natl Acad Sci U S A. 1989 May;86(9):3384-8. `PMID 2541446`_ * Blough HA et al. "Glycosylation inhibitors block the expression of LAV/HTLV-III (HIV) glycoproteins." Biochem Biophys Res Commun. 1986 Nov 26;141(1):33-8. `PMID 3099781`_ .. _PMID 2541446: http://www.ncbi.nlm.nih.gov/pubmed/2541446 .. _PMID 3099781: http://www.ncbi.nlm.nih.gov/pubmed/3099781