.. _MKRN2:

MKRN2
^^^^^

.. contents::
   :local:

General Information
*******************

:Full gene name: makorin ring finger protein 2
:Entrez Gene ID: 23609
:Location: 3p25
:Synonyms: HSPC070, RNF62
:Type: protein-coding

User SNPs
*********

SNPs given by the user that are near or inside this gene: 

+-----------+---------------+-----------+
|    SNP    | Distance (bp) | Direction |
+===========+===============+===========+
| rs1801282 |     205469    |  upstream |
+-----------+---------------+-----------+

.. _MKRN2 Gene summary:

NCBI Summary
************

Members of the makorin family, including MKRN2, have a characteristic zinc finger composition that suggests that they are ribonucleoproteins (Gray et al., 2001 [PubMed 11597136]).[supplied by OMIM, Mar 2008]

.. _OMIM ID 608426
                        : http://omim.org/entry/608426
                        

.. _MKRN2 OMIM Text:

OMIM
****

:OMIM ID: `OMIM ID 608426
                        `_


.. _MKRN2 Phenotype:

NCBI Phenotypes
***************

No phenotypes found linked to this gene.

.. _MKRN2 GO Term:

Gene Ontology
*************

* nucleic acid binding
* intracellular
* molecular_function
* zinc ion binding
* ligase activity
* biological_process
* protein ubiquitination

.. _MKRN2 Pathway:

KEGG Pathways
*************

No pathways found linked to this gene.

.. _MKRN2 GeneRIF:

GeneRIFs
********

* Two-hybrid [`PMID 19549727`_]
* Affinity Capture-MS [`PMID 22118674`_]
* MKRN2 and RAF1 are co-expressed in tissues and cell lines [`PMID 11597136`_]
* Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator) [`PMID 21048031`_]

.. _PMID 19549727: http://www.ncbi.nlm.nih.gov/pubmed/19549727
.. _PMID 22118674: http://www.ncbi.nlm.nih.gov/pubmed/22118674
.. _PMID 11597136: http://www.ncbi.nlm.nih.gov/pubmed/11597136
.. _PMID 21048031: http://www.ncbi.nlm.nih.gov/pubmed/21048031

.. _MKRN2 Pubmed:

PubMed Articles
***************

*Recent articles:*

* Altun M et al. "Activity-based chemical proteomics accelerates inhibitor development for deubiquitylating enzymes." Chem Biol. 2011 Nov 23;18(11):1401-12. `PMID 22118674`_
* Danielsen JM et al. "Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level." Mol Cell Proteomics. 2011 Mar;10(3):M110.003590. `PMID 21139048`_
* Casabonne D et al. "Single nucleotide polymorphisms of matrix metalloproteinase 9 (MMP9) and tumor protein 73 (TP73) interact with Epstein-Barr virus in chronic lymphocytic leukemia: results from the European case-control study EpiLymph." Haematologica. 2011 Feb;96(2):323-7. `PMID 21048031`_
* Markson G et al. "Analysis of the human E2 ubiquitin conjugating enzyme protein interaction network." Genome Res. 2009 Oct;19(10):1905-11. `PMID 19549727`_
* Gerhard DS et al. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." Genome Res. 2004 Oct;14(10B):2121-7. `PMID 15489334`_
* Ota T et al. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat Genet. 2004 Jan;36(1):40-5. `PMID 14702039`_
* Strausberg RL et al. "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences." Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. `PMID 12477932`_
* Gray TA et al. "Phylogenetic conservation of the makorin-2 gene, encoding a multiple zinc-finger protein, antisense to the RAF1 proto-oncogene." Genomics. 2001 Oct;77(3):119-26. `PMID 11597136`_
* Zhang QH et al. "Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells." Genome Res. 2000 Oct;10(10):1546-60. `PMID 11042152`_

.. _PMID 19549727: http://www.ncbi.nlm.nih.gov/pubmed/19549727
.. _PMID 12477932: http://www.ncbi.nlm.nih.gov/pubmed/12477932
.. _PMID 14702039: http://www.ncbi.nlm.nih.gov/pubmed/14702039
.. _PMID 21139048: http://www.ncbi.nlm.nih.gov/pubmed/21139048
.. _PMID 22118674: http://www.ncbi.nlm.nih.gov/pubmed/22118674
.. _PMID 11597136: http://www.ncbi.nlm.nih.gov/pubmed/11597136
.. _PMID 11042152: http://www.ncbi.nlm.nih.gov/pubmed/11042152
.. _PMID 21048031: http://www.ncbi.nlm.nih.gov/pubmed/21048031
.. _PMID 15489334: http://www.ncbi.nlm.nih.gov/pubmed/15489334