.. _MTNR1B: MTNR1B ^^^^^^ .. contents:: :local: General Information ******************* :Full gene name: melatonin receptor 1B :Entrez Gene ID: 4544 :Location: 11q21-q22 :Synonyms: MT2, MEL-1B-R, FGQTL2 :Type: protein-coding User SNPs ********* SNPs given by the user that are near or inside this gene: +------------+---------------+-----------+ | SNP | Distance (bp) | Direction | +============+===============+===========+ | rs10830963 | 0 | within | +------------+---------------+-----------+ .. _MTNR1B Gene summary: NCBI Summary ************ This gene encodes one of two high affinity forms of a receptor for melatonin, the primary hormone secreted by the pineal gland. This gene product is an integral membrane protein that is a G-protein coupled, 7-transmembrane receptor. It is found primarily in the retina and brain although this detection requires RT-PCR. It is thought to participate in light-dependent functions in the retina and may be involved in the neurobiological effects of melatonin. [provided by RefSeq, Jul 2008] .. _OMIM ID 600804 : http://omim.org/entry/600804 .. _MTNR1B OMIM Text: OMIM **** :OMIM ID: `OMIM ID 600804 `_ **Allelic Variants (Selected Examples)** .0001 \ ``DIABETES``\ MELLITUS, TYPE 2, SUSCEPTIBILITY TO In a large-scale exon resequencing of the MTNR1B gene in 7,632 Europeans, including 2,186 individuals with type 2 \ ``DIABETES``\ (T2D; 125853), Bonnefond et al. (2012) identified a G-to-C transversion at genomic coordinate Chr11:92,342,663 (NCBI36), resulting in an ala42-to-pro (A42P) substitution in the predicted transmembrane domain I. The mutation is rare, with a minor allele frequency of less than 0.1%, and functional analysis in HEK293 cells demonstrated that the A42P variant has no I(125)MLT binding ability and does not activate downstream G(i)-protein-dependent or ERK1 (601795)/2 (176948) signaling pathways. Analysis of this and 3 other complete loss-of-function MTNR1B variants (L60R, 600804.0002; P95L, 600804.0003; and Y308S, 600804.0004) as a pool in 11,854 individuals, including 5,967 with T2D, demonstrated their association with T2D (odds ratio, 3.88; p = 5.37 x 10(-3)). .0002 \ ``DIABETES``\ MELLITUS, TYPE 2, SUSCEPTIBILITY TO In a large-scale exon resequencing of the MTNR1B gene in 7,632 Europeans, including 2,186 individuals with type 2 \ ``DIABETES``\ (T2D; 125853), Bonnefond et al. (2012) identified a T-to-G transversion at genomic coordinate Chr11:92,342,718 (NCBI36), resulting in a leu60-to-arg (L60R) substitution in the predicted transmembrane domain I. The mutation is rare, with a minor allele frequency of less than 0.1%, and functional analysis in HEK293 cells demonstrated that the L60R variant has no I(125)MLT binding ability and does not activate downstream G(i)-protein-dependent or ERK1 (601795)/2 (176948) signaling pathways. Analysis of this and 3 other complete loss-of-function MTNR1B variants (A42P, 600804.0001; P95L, 600804.0003; and Y308S, 600804.0004) as a pool in 11,854 individuals, including 5,967 with T2D, demonstrated their association with T2D (odds ratio, 3.88; p = 5.37 x 10(-3)). .0003 \ ``DIABETES``\ MELLITUS, TYPE 2, SUSCEPTIBILITY TO In a large-scale exon resequencing of the MTNR1B gene in 7,632 Europeans, including 2,186 individuals with type 2 \ ``DIABETES``\ (T2D; 125853), Bonnefond et al. (2012) identified a C-to-T transition at genomic coordinate Chr11:92,354,321 (NCBI36), resulting in a pro95-to-leu (P95L) substitution in the predicted transmembrane domain II. The mutation is rare, with a minor allele frequency of less than 0.1%, and functional analysis in HEK293 cells demonstrated that the P95L variant has no I(125)MLT binding ability and does not activate downstream G(i)-protein-dependent or ERK1 (601795)/2 (176948) signaling pathways. Analysis of this and 3 other complete loss-of-function MTNR1B variants (A42P, 600804.0001; L60R, 600804.0002; and Y308S, 600804.0004) as a pool in 11,854 individuals, including 5,967 with T2D, demonstrated their association with T2D (odds ratio, 3.88; p = 5.37 x 10(-3)). .0004 \ ``DIABETES``\ MELLITUS, TYPE 2, SUSCEPTIBILITY TO In a large-scale exon resequencing of the MTNR1B gene in 7,632 Europeans, including 2,186 individuals with type 2 \ ``DIABETES``\ (T2D; 125853), Bonnefond et al. (2012) identified a A-to-C transversion at genomic coordinate Chr11:92,354,963 (NCBI36), resulting in a tyr308-to-ser (Y308S) substitution within a conserved motif in the predicted transmembrane domain VII. The mutation is rare, with a minor allele frequency of less than 0.1%, and functional analysis in HEK293 cells demonstrated that the Y308S variant has no I(125)MLT binding ability and does not activate downstream G(i)-protein-dependent or ERK1 (601795)/2 (176948) signaling pathways. Analysis of this and 3 other complete loss-of-function MTNR1B variants (A42P, 600804.0001; L60R, 600804.0002; and P95L, 600804.0003) as a pool in 11,854 individuals, including 5,967 with T2D, demonstrated their association with T2D (odds ratio, 3.88; p = 5.37 x 10(-3)). .. _MTNR1B Phenotype: NCBI Phenotypes *************** * Gene Reviews * Common variants at 10 genomic loci influence hemoglobin A₁(C) levels via glycemic and nonglycemic pathways. * Genome-wide screen for metabolic syndrome susceptibility Loci reveals strong lipid gene contribution but no evidence for common genetic basis for clustering of metabolic syndrome traits. * A variant near MTNR1B is associated with increased fasting plasma \ ``glucose``\ levels and type 2 \ ``diabetes``\ risk. * Variants in MTNR1B influence fasting \ ``glucose``\ levels. * A genome-wide association study of gestational \ ``diabetes``\ mellitus in Korean women. * Genome-wide association analysis of metabolic traits in a birth cohort from a founder population. * Genome-wide association study identifies multiple loci influencing human serum metabolite levels. * \ ``Diabetes``\ mellitus type 2 * Twelve type 2 \ ``diabetes``\ susceptibility loci identified through large-scale association analysis. * OMIM * Common genetic variation near melatonin receptor MTNR1B contributes to raised plasma \ ``glucose``\ and increased risk of type 2 \ ``diabetes``\ among Indian Asians and European Caucasians. * New genetic loci implicated in fasting \ ``glucose``\ homeostasis and their impact on type 2 \ ``diabetes``\ risk. * GTR * Large-scale genome-wide association studies in East Asians identify new genetic loci influencing metabolic traits. * Fasting \ ``glucose``\ GWAS candidate region analysis across ethnic groups in the Multiethnic Study of Atherosclerosis (MESA). * NHGRI GWA Catalog .. _MTNR1B GO Term: Gene Ontology ************* * G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger * regulation of \ ``insulin``\ secretion * \ ``glucose``\ homeostasis * melatonin receptor activity * synaptic transmission * G-protein coupled receptor activity * integral to plasma membrane * plasma membrane .. _MTNR1B Pathway: KEGG Pathways ************* * `Neuroactive ligand-receptor interaction `_ .. _MTNR1B GeneRIF: GeneRIFs ******** * Results suggest that common genetic variation in the MTNR1a and 1b genes may contribute to breast cancer susceptibility, and that associations may vary by menopausal status. [`PMID 22138747`_] * Expression in cultured skin cells. [`PMID 12767050`_] * variants in MTNR1B confer pancreatic beta-cell dysfunction [`PMID 20597807`_] * MT(2) melatonin receptor may have undergone a selective pressure in response to global variation in sunshine duration. selection of rs4753426C allele would insure that carriers adapted to local daily and seasonal rhythms more quickly [`PMID 20050988`_] * Observational study of genotype prevalence. (HuGE Navigator) [`PMID 20050988`_] * The rs10830963 polymorphism in MTNR1B was associated with increased fasting \ ``glucose``\ and risk of impaired fasting \ ``glucose``\ in Chinese children and adolescents. [`PMID 21701235`_] * Study identified six non-synonymous mutations for MTNR1A and ten for MTNR1B in autism spectrum disorders patients . The majority of these variations altered receptor function. [`PMID 20657642`_] * Meta-analysis and genome-wide association study of gene-disease association. (HuGE Navigator) [`PMID 19060907`_] * Variants in the gene encoding melatonin receptor 1B (MTNR1B) were consistently associated with fasting \ ``glucose``\ across all ten studies. [`PMID 19060907`_] * There were significant associations between the two genetic variants (rs10830963 and rs1387153) of the melatonin receptor 1B gene and gestational \ ``diabetes``\ mellitus. [`PMID 21658282`_] * role of proline residues in structure & function of the MT2 receptor; results indicate residues P174, P212 & P266 are important for ligand binding and/or signaling of the MT2 receptor [`PMID 18544139`_] * There is no effect by the common gene variant rs10830963 of the melatonin receptor 1B on the association between sleep disturbances and type 2 \ ``diabetes``\ . [`PMID 21380592`_] * Rare MTNR1B variants impairing melatonin receptor 1B function contribute to type 2 \ ``diabetes``\ . [`PMID 22286214`_] * Polymorphisms of the promoter of MTNR1B gene were associated with AIS, but not with the curve severity in AIS patients. This suggested that MTNR1B was an AIS predisposition gene. [`PMID 17632395`_] * These data suggest a possible link between circadian rhythm regulation and \ ``glucose``\ homeostasis through the melatonin signaling pathway. [`PMID 19060909`_] * Observational study of gene-disease association, gene-gene interaction, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator) [`PMID 20879858`_] * Melatonin synergizes with oxytocin to promote myometrial cell contractions in vitro, which in vivo would promote coordinated and forceful contractions of the late term pregnant uterus necessary for parturition. [`PMID 19001515`_] * melatonin receptor type 1B polymorphism is associated with the presence of rheumatoid factor in Korean rheumatoid arthritis [`PMID 16098099`_] * The results of this study suggested that the Single nucleotide polymorphisms MT(2) receptor gene influence the risk of recurrent depressive disorder. [`PMID 21353709`_] * These data suggest that the circulating hormone melatonin, which is predominantly released from the pineal gland in the brain, is involved in the pathogenesis of type 2 \ ``diabetes``\ . [`PMID 19060908`_] * Six SNP(rs7754840 in CDKAL1, rs391300 in SRR, rs2383208 in CDKN2A/2B, rs4402960 in IGF2BP2, rs10830963 in MTNR1B, rs4607517 in GCK)risk alleles of type 2 \ ``diabetes``\ were associated with GDM in pregnant Chinese women. [`PMID 22096510`_] * Melatonin has a modulating effect on dopaminergic neurotransmission in the brain. Read More: http://informahealthcare.com/doi/full/10.3109/15622975.2010.496870 [`PMID 20726823`_] * Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator) [`PMID 20726823`_] * Variations and single-nucleotide polymorphisms are associated in variations in fasting plasma \ ``glucose``\ and an increased risk of type 2 \ ``diabetes``\ . [`PMID 19533084`_] * Study showed that SNPs from GCK, G6PC2 and MTNR1B modulated the fasting \ ``glucose``\ levels in the normoglycaemic population while SNPs from G6PC2 and GCKR was associated with type 2 \ ``diabetes``\ . [`PMID 20668700`_] * Observational study, meta-analysis, and genome-wide association study of gene-disease association. (HuGE Navigator) [`PMID 20858683`_] * A common variant in the MTNR1B gene is associated with an increased risk of type 2 \ ``diabetes``\ and increased fasting plasma \ ``glucose``\ in Han Chinese. [`PMID 19241057`_] * A common variant in MTNR1B was associated with fasting \ ``glucose``\ , HbA1C and HOMA-B but not with sleep status in Chinese Hans from Shanghai. [`PMID 20398260`_] * residues N268 and A275 in TM6 as well as residues V291 and L295 in TM7 are essential for 2-iodomelatonin binding to the MT2 receptor [`PMID 15913560`_] * MT2 receptor is involved in mediating the \ ``insulin``\ - and cGMP-inhibiting action of melatonin in panreatic beta cells. [`PMID 18363673`_] * Observational study of gene-disease association, gene-gene interaction, and gene-environment interaction. (HuGE Navigator) [`PMID 20889853`_] * The G-allele of rs10830693 in the MTNR1B gene was significantly related to \ ``glucose``\ levels, while an impact of this genetic variant on the changes in \ ``glucose``\ metabolism in children participating in a lifestyle intervention was not observable. [`PMID 21366812`_] * Fasting \ ``glucose``\ association at MTNR1b is replicable across ethnic groups, although ethnic diversity in the pattern and strength of linkage disequilibrium exists. [`PMID 19937311`_] * Genetic variation in this protein may contribute to abnormal \ ``glucose``\ metabolism and related metabolic disturbances among Indian Asians. [`PMID 19651812`_] * Observational study and genome-wide association study of gene-disease association. (HuGE Navigator) [`PMID 19651812`_] * No significant differences were found in the hMel-1B and RORa receptors in patients with adolescent idiopathic scoliosis compared with controls [`PMID 20733416`_] * G-allele increases risk of type 2 \ ``diabetes``\ and associates with estimates of beta-cell dysfunction and hepatic \ ``insulin``\ resistance. [`PMID 19324940`_] * Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator) [`PMID 20802253`_] * Genetic variation of MTNR1B is associated with defective early \ ``insulin``\ response and decreased beta cell \ ``glucose``\ sensitivity. [`PMID 19455304`_] * MTNR1B contributes to the phenotypic expression of polycystic ovary syndrome. [`PMID 20207350`_] * Children and adolescents carrying \ ``glucose``\ -raising alleles of G6PC2, MTNR1B, GCK, and GLIS3 also showed reduced beta-cell function, as indicated by homeostasis model assessment of beta-cell function. [`PMID 21515849`_] * Common variants of MTNR1B, G6PC2 and GCK are associated with elevated FPG and impaired \ ``insulin``\ secretion, both individually and jointly, suggesting that these risk alleles may precipitate or perpetuate hyperglycemia in predisposed individuals. [`PMID 20628598`_] * Observational study and meta-analysis of gene-disease association. (HuGE Navigator) [`PMID 20628598`_] * Truncation of the C-terminal tail of both receptors (MT(1)Y7.64 and MT(2)Y7.64) inhibited internalization as well as the cAMP response, suggesting the importance of the C-terminal tail in these receptor functions. [`PMID 18341518`_] * The rs3781637 A/G polymorphism of the MTNR1B gene is associated with type 2 \ ``diabetes``\ , plasma, total cholesterol and LDL-C levels in the Han Chinese population. [`PMID 21470412`_] * SNPs within the MTNR1B gene are associated with polycystic ovary syndrome in Han Chinese women. [`PMID 20959387`_] * Melatonin inhibited ERalpha mRNA expression & enhanced induction of pancreatic spasmolytic polypeptide in MT(1)-transfected breast cancer cells, suggesting a role for the MT(1) receptor in melatonin-regulated growth-suppression & gene-modulation. [`PMID 12088876`_] * The results demonstrate a down-regulation of melatonin receptors in regions affected by Parkinson disease, suggesting their possible involvement in the disease process. [`PMID 20110911`_] * Data suggest that the genetic effect of promoter polymorphisms of BMP4, IL6, leptin, MMP3, and MTNR1B can be synergistic for susceptibility to AIS. [`PMID 21228692`_] * MTNR1B variations associate with with increased body mass and decreased fasting blood \ ``glucose``\ in Europeans. [`PMID 20200315`_] * Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator) [`PMID 19808892`_] * This study confirms the association of gestational \ ``diabetes``\ mellitus with the rs10830963 variant in a sample of the Greek population. [`PMID 22450346`_] * we concluded that MTNR1B SNP is not associated with either adolescent idiopathic scoliosis predisposition or curve severity in Japanese. [`PMID 21308753`_] * Common genetic variation within MTNR1B determines \ ``glucose``\ -stimulated \ ``insulin``\ secretion and plasma \ ``glucose``\ concentrations. [`PMID 19088850`_] * The common variant in MTNR1B confers the risk of Type 2 \ ``diabetes``\ and modulates FPG in both the Han Chinese and European populations. [`PMID 20536959`_] * MT(2) was localized to ganglion and bipolar cells in the inner nuclear layer, and to the inner segments of the photoreceptor cells, cellular processes in inner and outer plexiform layers . In AD patients intensity of MT(2)-staining was decreased. [`PMID 17316165`_] * Monitoring of ligand-independent dimerization and ligand-induced conformational changes of melatonin receptors in living cells by bioluminescence resonance energy transfer (melatonin receptor 2) [`PMID 11940583`_] * MT2 receptor interacts with melatonin. [`PMID 15266022`_] * MT1 receptor heterodimerizes with MT2 receptor. [`PMID 15266022`_] * MT2 receptor homodimerizes with itself. [`PMID 15266022`_] * This is the first single study, replicating the association between the MTNR1B locus and \ ``diabetes``\ -related traits in overweight and obese children and adolescents. [`PMID 21059861`_] * Observational study of gene-disease association. (HuGE Navigator) [`PMID 21059861`_] .. _PMID 22138747: http://www.ncbi.nlm.nih.gov/pubmed/22138747 .. _PMID 12767050: http://www.ncbi.nlm.nih.gov/pubmed/12767050 .. _PMID 20597807: http://www.ncbi.nlm.nih.gov/pubmed/20597807 .. _PMID 20050988: http://www.ncbi.nlm.nih.gov/pubmed/20050988 .. _PMID 21701235: http://www.ncbi.nlm.nih.gov/pubmed/21701235 .. _PMID 20657642: http://www.ncbi.nlm.nih.gov/pubmed/20657642 .. _PMID 19060907: http://www.ncbi.nlm.nih.gov/pubmed/19060907 .. _PMID 21658282: http://www.ncbi.nlm.nih.gov/pubmed/21658282 .. _PMID 18544139: http://www.ncbi.nlm.nih.gov/pubmed/18544139 .. _PMID 21380592: http://www.ncbi.nlm.nih.gov/pubmed/21380592 .. _PMID 22286214: http://www.ncbi.nlm.nih.gov/pubmed/22286214 .. _PMID 17632395: http://www.ncbi.nlm.nih.gov/pubmed/17632395 .. _PMID 19060909: http://www.ncbi.nlm.nih.gov/pubmed/19060909 .. _PMID 20879858: http://www.ncbi.nlm.nih.gov/pubmed/20879858 .. _PMID 19001515: http://www.ncbi.nlm.nih.gov/pubmed/19001515 .. _PMID 16098099: http://www.ncbi.nlm.nih.gov/pubmed/16098099 .. _PMID 21353709: http://www.ncbi.nlm.nih.gov/pubmed/21353709 .. _PMID 19060908: http://www.ncbi.nlm.nih.gov/pubmed/19060908 .. _PMID 22096510: http://www.ncbi.nlm.nih.gov/pubmed/22096510 .. _PMID 20726823: http://www.ncbi.nlm.nih.gov/pubmed/20726823 .. _PMID 19533084: http://www.ncbi.nlm.nih.gov/pubmed/19533084 .. _PMID 20668700: http://www.ncbi.nlm.nih.gov/pubmed/20668700 .. _PMID 20858683: http://www.ncbi.nlm.nih.gov/pubmed/20858683 .. _PMID 19241057: http://www.ncbi.nlm.nih.gov/pubmed/19241057 .. _PMID 20398260: http://www.ncbi.nlm.nih.gov/pubmed/20398260 .. _PMID 15913560: http://www.ncbi.nlm.nih.gov/pubmed/15913560 .. _PMID 18363673: http://www.ncbi.nlm.nih.gov/pubmed/18363673 .. _PMID 20889853: http://www.ncbi.nlm.nih.gov/pubmed/20889853 .. _PMID 21366812: http://www.ncbi.nlm.nih.gov/pubmed/21366812 .. _PMID 19937311: http://www.ncbi.nlm.nih.gov/pubmed/19937311 .. _PMID 19651812: http://www.ncbi.nlm.nih.gov/pubmed/19651812 .. _PMID 20733416: http://www.ncbi.nlm.nih.gov/pubmed/20733416 .. _PMID 19324940: http://www.ncbi.nlm.nih.gov/pubmed/19324940 .. _PMID 20802253: http://www.ncbi.nlm.nih.gov/pubmed/20802253 .. _PMID 19455304: http://www.ncbi.nlm.nih.gov/pubmed/19455304 .. _PMID 20207350: http://www.ncbi.nlm.nih.gov/pubmed/20207350 .. _PMID 21515849: http://www.ncbi.nlm.nih.gov/pubmed/21515849 .. _PMID 20628598: http://www.ncbi.nlm.nih.gov/pubmed/20628598 .. _PMID 18341518: http://www.ncbi.nlm.nih.gov/pubmed/18341518 .. _PMID 21470412: http://www.ncbi.nlm.nih.gov/pubmed/21470412 .. _PMID 20959387: http://www.ncbi.nlm.nih.gov/pubmed/20959387 .. _PMID 12088876: http://www.ncbi.nlm.nih.gov/pubmed/12088876 .. _PMID 20110911: http://www.ncbi.nlm.nih.gov/pubmed/20110911 .. _PMID 21228692: http://www.ncbi.nlm.nih.gov/pubmed/21228692 .. _PMID 20200315: http://www.ncbi.nlm.nih.gov/pubmed/20200315 .. _PMID 19808892: http://www.ncbi.nlm.nih.gov/pubmed/19808892 .. _PMID 22450346: http://www.ncbi.nlm.nih.gov/pubmed/22450346 .. _PMID 21308753: http://www.ncbi.nlm.nih.gov/pubmed/21308753 .. _PMID 19088850: http://www.ncbi.nlm.nih.gov/pubmed/19088850 .. _PMID 20536959: http://www.ncbi.nlm.nih.gov/pubmed/20536959 .. _PMID 17316165: http://www.ncbi.nlm.nih.gov/pubmed/17316165 .. _PMID 11940583: http://www.ncbi.nlm.nih.gov/pubmed/11940583 .. _PMID 15266022: http://www.ncbi.nlm.nih.gov/pubmed/15266022 .. _PMID 21059861: http://www.ncbi.nlm.nih.gov/pubmed/21059861 .. _MTNR1B Pubmed: PubMed Articles *************** *Recent articles:* * Rasmussen-Torvik LJ et al. "Fasting glucose GWAS candidate region analysis across ethnic groups in the Multiethnic Study of Atherosclerosis (MESA)." Genet Epidemiol. 2012 May;36(4):384-91. `PMID 22508271`_ * Deming SL et al. "Melatonin pathway genes and breast cancer risk among Chinese women." Breast Cancer Res Treat. 2012 Apr;132(2):693-9. `PMID 22138747`_ * Kristiansson K et al. "Genome-wide screen for metabolic syndrome susceptibility Loci reveals strong lipid gene contribution but no evidence for common genetic basis for clustering of metabolic syndrome traits." Circ Cardiovasc Genet. 2012 Apr 1;5(2):242-9. `PMID 22399527`_ * Vlassi M et al. "The rs10830963 variant of melatonin receptor MTNR1B is associated with increased risk for gestational diabetes mellitus in a Greek population." Hormones (Athens). 2012 Jan-Mar;11(1):70-6. `PMID 22450346`_ * Kwak SH et al. "A genome-wide association study of gestational diabetes mellitus in Korean women." Diabetes. 2012 Feb;61(2):531-41. `PMID 22233651`_ * Kettunen J et al. "Genome-wide association study identifies multiple loci influencing human serum metabolite levels." Nat Genet. 2012 Jan 29;44(3):269-76. `PMID 22286219`_ * Bonnefond A et al. "Rare MTNR1B variants impairing melatonin receptor 1B function contribute to type 2 diabetes." Nat Genet. 2012 Jan 29;44(3):297-301. `PMID 22286214`_ * Wang Y et al. "Association of six single nucleotide polymorphisms with gestational diabetes mellitus in a Chinese population." PLoS One. 2011;6(11):e26953. `PMID 22096510`_ * Kim YJ et al. "Large-scale genome-wide association studies in East Asians identify new genetic loci influencing metabolic traits." Nat Genet. 2011 Sep 11;43(10):990-5. `PMID 21909109`_ * Song JY et al. "Association of the rs10830963 polymorphism in MTNR1B with fasting glucose levels in Chinese children and adolescents." Obes Facts. 2011;4(3):197-203. `PMID 21701235`_ .. _PMID 22138747: http://www.ncbi.nlm.nih.gov/pubmed/22138747 .. _PMID 22233651: http://www.ncbi.nlm.nih.gov/pubmed/22233651 .. _PMID 21701235: http://www.ncbi.nlm.nih.gov/pubmed/21701235 .. _PMID 22450346: http://www.ncbi.nlm.nih.gov/pubmed/22450346 .. _PMID 21909109: http://www.ncbi.nlm.nih.gov/pubmed/21909109 .. _PMID 22096510: http://www.ncbi.nlm.nih.gov/pubmed/22096510 .. _PMID 22286219: http://www.ncbi.nlm.nih.gov/pubmed/22286219 .. _PMID 22286214: http://www.ncbi.nlm.nih.gov/pubmed/22286214 .. _PMID 22399527: http://www.ncbi.nlm.nih.gov/pubmed/22399527 .. _PMID 22508271: http://www.ncbi.nlm.nih.gov/pubmed/22508271 *Top Pubmed articles linked to gene MTNR1B matching any search term:* * Peter I et al. "Association of Type 2 Diabetes Susceptibility Loci With One-Year Weight Loss in the Look AHEAD Clinical Trial." Obesity (Silver Spring). 2012 Aug;20(8):1675-82. `PMID 22307069`_ * Liao S et al. "Association of Genetic Variants of Melatonin Receptor 1B with Gestational Plasma Glucose Level and Risk of Glucose Intolerance in Pregnant Chinese Women." PLoS One. 2012;7(7):e40113. `PMID 22768333`_ * Linder K et al. "Allele summation of diabetes risk genes predicts impaired glucose tolerance in female and obese individuals." PLoS One. 2012;7(6):e38224. `PMID 22768041`_ * Hotta K et al. "Association between type 2 diabetes genetic susceptibility loci and visceral and subcutaneous fat area as determined by computed tomography." J Hum Genet. 2012 May;57(5):305-10. `PMID 22377712`_ * Rasmussen-Torvik LJ et al. "Fasting glucose GWAS candidate region analysis across ethnic groups in the Multiethnic Study of Atherosclerosis (MESA)." Genet Epidemiol. 2012 May;36(4):384-91. `PMID 22508271`_ * Grimsby JL et al. "Race-ethnic differences in the association of genetic loci with HbA1c levels and mortality in U.S. adults: the third National Health and Nutrition Examination Survey (NHANES III)." BMC Med Genet. 2012 Apr 27;13(1):30. `PMID 22540250`_ * Winkler C et al. "Lack of association of type 2 diabetes susceptibility genotypes and body weight on the development of islet autoimmunity and type 1 diabetes." PLoS One. 2012;7(4):e35410. `PMID 22558147`_ * Deming SL et al. "Melatonin pathway genes and breast cancer risk among Chinese women." Breast Cancer Res Treat. 2012 Apr;132(2):693-9. `PMID 22138747`_ * Vlassi M et al. "The rs10830963 variant of melatonin receptor MTNR1B is associated with increased risk for gestational diabetes mellitus in a Greek population." Hormones (Athens). 2012 Jan-Mar;11(1):70-6. `PMID 22450346`_ * Kwak SH et al. "A genome-wide association study of gestational diabetes mellitus in Korean women." Diabetes. 2012 Feb;61(2):531-41. `PMID 22233651`_ * Bonnefond A et al. "Rare MTNR1B variants impairing melatonin receptor 1B function contribute to type 2 diabetes." Nat Genet. 2012 Jan 29;44(3):297-301. `PMID 22286214`_ * Kim YJ et al. "Large-scale genome-wide association studies in East Asians identify new genetic loci influencing metabolic traits." Nat Genet. 2011 Sep 11;43(10):990-5. `PMID 21909109`_ * Takahashi Y et al. "Lack of association between adolescent idiopathic scoliosis and previously reported single nucleotide polymorphisms in MATN1, MTNR1B, TPH1, and IGF1 in a Japanese population." J Orthop Res. 2011 Jul;29(7):1055-8. `PMID 21308753`_ * Song JY et al. "Association of the rs10830963 polymorphism in MTNR1B with fasting glucose levels in Chinese children and adolescents." Obes Facts. 2011;4(3):197-203. `PMID 21701235`_ * Reinehr T et al. "Relationship between MTNR1B (melatonin receptor 1B gene) polymorphism rs10830963 and glucose levels in overweight children and adolescents." Pediatr Diabetes. 2011 Jun;12(4 Pt 2):435-41. `PMID 21366812`_ * Holzapfel C et al. "Association of a MTNR1B gene variant with fasting glucose and HOMA-B in children and adolescents with high BMI-SDS." Eur J Endocrinol. 2011 Feb;164(2):205-12. `PMID 21059861`_ * de Miguel-Yanes JM et al. "Genetic risk reclassification for type 2 diabetes by age below or above 50 years using 40 type 2 diabetes risk single nucleotide polymorphisms." Diabetes Care. 2011 Jan;34(1):121-5. `PMID 20889853`_ * Soranzo N et al. "Common variants at 10 genomic loci influence hemoglobin A₁(C) levels via glycemic and nonglycemic pathways." 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