.. _NAP1L4: NAP1L4 ^^^^^^ .. contents:: :local: General Information ******************* :Full gene name: nucleosome assembly protein 1-like 4 :Entrez Gene ID: 4676 :Location: 11p15.5 :Synonyms: NAP2L, NAP1L4b, hNAP2, NAP2 :Type: protein-coding User SNPs ********* SNPs given by the user that are near or inside this gene: +-----------+---------------+------------+ | SNP | Distance (bp) | Direction | +===========+===============+============+ | rs2237892 | 125909 | downstream | +-----------+---------------+------------+ .. _NAP1L4 Gene summary: NCBI Summary ************ This gene encodes a member of the nucleosome assembly protein (NAP) family which can interact with both core and linker histones. It can shuttle between the cytoplasm and nucleus, suggesting a role as a histone chaperone. This gene is one of several located near the imprinted gene domain of 11p15.5, an important tumor-suppressor gene region. Alterations in this region have been associated with the Beckwith-Wiedemann syndrome, Wilms tumor, rhabdomyosarcoma, adrenocortical carcinoma, and lung, ovarian, and breast cancer. [provided by RefSeq, Jul 2008] .. _OMIM ID 601651 : http://omim.org/entry/601651 .. _NAP1L4 OMIM Text: OMIM **** :OMIM ID: `OMIM ID 601651 `_ .. _NAP1L4 Phenotype: NCBI Phenotypes *************** * Common variants in the calcium-sensing receptor gene are associated with total serum calcium levels. * NHGRI GWA Catalog .. _NAP1L4 GO Term: Gene Ontology ************* * cytoplasm * chromatin assembly complex * unfolded protein binding * nucleosome assembly .. _NAP1L4 Pathway: KEGG Pathways ************* No pathways found linked to this gene. .. _NAP1L4 GeneRIF: GeneRIFs ******** * The biochemical properties of two human NAP1-like proteins, hNAP1L1 and hNAP1L4, were characterized. [`PMID 20002496`_] * Affinity Capture-MS [`PMID 19135240`_] * Reconstituted Complex [`PMID 11073993`_] * Reconstituted Complex [`PMID 11073993`_] * Reconstituted Complex [`PMID 11073993`_] * Affinity Capture-Western; Reconstituted Complex; Two-hybrid [`PMID 11073993`_] * NAP-2 is in complex(es) with other proteins, which are distinct from histones [`PMID 15368365`_] * Results identified several proteins interacting with NAP1L2, including the ubiquitously expressed members of the nucleosome assembly protein family, NAP1L1 and NAP1L4. [`PMID 21333655`_] * Observational study and genome-wide association study of gene-disease association. (HuGE Navigator) [`PMID 20201924`_] * Affinity Capture-MS [`PMID 20360068`_] * Reconstituted Complex [`PMID 9325046`_] * Reconstituted Complex [`PMID 9325046`_] * Reconstituted Complex [`PMID 9325046`_] * Reconstituted Complex [`PMID 9325046`_] * Reconstituted Complex [`PMID 9325046`_] * Telomeric NAP1L4 and OSBPL5 of the KCNQ1 cluster, and the DECORIN gene are not imprinted in human trophoblast stem cells. [`PMID 20644730`_] * HIV-1 gp120 modulates expression of the chemokines, GRO-alpha (CXCL1), GRO-gamma, NAP2, IL-8, IP-10, MIP-1beta, MIP-1alpha, RANTES, and MIP-3alpha, in PBMCs and MDMs [`PMID 12089333`_] * Human Nap2 promotes nucleosome assembly with H3t/H4. [`PMID 18281699`_] * Affinity Capture-MS [`PMID 21906983`_] .. _PMID 20002496: http://www.ncbi.nlm.nih.gov/pubmed/20002496 .. _PMID 19135240: http://www.ncbi.nlm.nih.gov/pubmed/19135240 .. _PMID 11073993: http://www.ncbi.nlm.nih.gov/pubmed/11073993 .. _PMID 15368365: http://www.ncbi.nlm.nih.gov/pubmed/15368365 .. _PMID 21333655: http://www.ncbi.nlm.nih.gov/pubmed/21333655 .. _PMID 20201924: http://www.ncbi.nlm.nih.gov/pubmed/20201924 .. _PMID 20360068: http://www.ncbi.nlm.nih.gov/pubmed/20360068 .. _PMID 9325046: http://www.ncbi.nlm.nih.gov/pubmed/9325046 .. _PMID 20644730: http://www.ncbi.nlm.nih.gov/pubmed/20644730 .. _PMID 12089333: http://www.ncbi.nlm.nih.gov/pubmed/12089333 .. _PMID 18281699: http://www.ncbi.nlm.nih.gov/pubmed/18281699 .. _PMID 21906983: http://www.ncbi.nlm.nih.gov/pubmed/21906983 .. _NAP1L4 Pubmed: PubMed Articles *************** *Recent articles:* * Kim W et al. "Systematic and quantitative assessment of the ubiquitin-modified proteome." Mol Cell. 2011 Oct 21;44(2):325-40. `PMID 21906983`_ * Wagner SA et al. "A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles." Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. `PMID 21890473`_ * Attia M et al. "Interaction between nucleosome assembly protein 1-like family members." J Mol Biol. 2011 Apr 15;407(5):647-60. `PMID 21333655`_ * Danielsen JM et al. "Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level." Mol Cell Proteomics. 2011 Mar;10(3):M110.003590. `PMID 21139048`_ * O'Seaghdha CM et al. "Common variants in the calcium-sensing receptor gene are associated with total serum calcium levels." Hum Mol Genet. 2010 Nov 1;19(21):4296-303. `PMID 20705733`_ * Frost JM et al. "Telomeric NAP1L4 and OSBPL5 of the KCNQ1 cluster, and the DECORIN gene are not imprinted in human trophoblast stem cells." PLoS One. 2010 Jul 14;5(7):e11595. `PMID 20644730`_ * Edenberg HJ et al. "Genome-wide association study of alcohol dependence implicates a region on chromosome 11." Alcohol Clin Exp Res. 2010 May;34(5):840-52. `PMID 20201924`_ * Hutchins JR et al. "Systematic analysis of human protein complexes identifies chromosome segregation proteins." Science. 2010 Apr 30;328(5978):593-9. `PMID 20360068`_ * Okuwaki M et al. "Functional characterization of human nucleosome assembly protein 1-like proteins as histone chaperones." Genes Cells. 2010 Jan;15(1):13-27. `PMID 20002496`_ * Sumara G et al. "Regulation of PKD by the MAPK p38delta in insulin secretion and glucose homeostasis." Cell. 2009 Jan 23;136(2):235-48. `PMID 19135240`_ .. _PMID 21890473: http://www.ncbi.nlm.nih.gov/pubmed/21890473 .. _PMID 20705733: http://www.ncbi.nlm.nih.gov/pubmed/20705733 .. _PMID 19135240: http://www.ncbi.nlm.nih.gov/pubmed/19135240 .. _PMID 20002496: http://www.ncbi.nlm.nih.gov/pubmed/20002496 .. _PMID 21333655: http://www.ncbi.nlm.nih.gov/pubmed/21333655 .. _PMID 21139048: http://www.ncbi.nlm.nih.gov/pubmed/21139048 .. _PMID 20201924: http://www.ncbi.nlm.nih.gov/pubmed/20201924 .. _PMID 20360068: http://www.ncbi.nlm.nih.gov/pubmed/20360068 .. _PMID 20644730: http://www.ncbi.nlm.nih.gov/pubmed/20644730 .. _PMID 21906983: http://www.ncbi.nlm.nih.gov/pubmed/21906983 *Top Pubmed articles linked to gene NAP1L4 matching any search term:* * Sumara G et al. "Regulation of PKD by the MAPK p38delta in insulin secretion and glucose homeostasis." Cell. 2009 Jan 23;136(2):235-48. `PMID 19135240`_ * Catchpoole D et al. "Mutation analysis of H19 and NAP1L4 (hNAP2) candidate genes and IGF2 DMR2 in Beckwith-Wiedemann syndrome." J Med Genet. 2000 Mar;37(3):212-5. `PMID 10777363`_ * Hu RJ et al. "A novel human homologue of yeast nucleosome assembly protein, 65 kb centromeric to the p57KIP2 gene, is biallelically expressed in fetal and adult tissues." Hum Mol Genet. 1996 Nov;5(11):1743-8. `PMID 8923002`_ .. _PMID 19135240: http://www.ncbi.nlm.nih.gov/pubmed/19135240 .. _PMID 8923002: http://www.ncbi.nlm.nih.gov/pubmed/8923002 .. _PMID 10777363: http://www.ncbi.nlm.nih.gov/pubmed/10777363