.. _NCR3LG1:

NCR3LG1
^^^^^^^

.. contents::
   :local:

General Information
*******************

:Full gene name: natural killer cell cytotoxicity receptor 3 ligand 1
:Entrez Gene ID: 374383
:Location: 11p15.1
:Synonyms: DKFZp686O24166, B7H6, B7-H6
:Type: protein-coding

User SNPs
*********

SNPs given by the user that are near or inside this gene: 

+--------+---------------+------------+
|  SNP   | Distance (bp) | Direction  |
+========+===============+============+
| rs5215 |      9762     | downstream |
+--------+---------------+------------+

.. _NCR3LG1 Gene summary:

NCBI Summary
************

B7H6 belongs to the B7 family (see MIM 605402) and is selectively expressed on tumor cells. Interaction of B7H6 with NKp30 (NCR3; MIM 611550) results in natural killer (NK) cell activation and cytotoxicity (Brandt et al., 2009 [PubMed 19528259]).[supplied by OMIM, Jan 2011]

.. _NCR3LG1 OMIM Text:

OMIM
****

No OMIM data available for this gene.

.. _NCR3LG1 Phenotype:

NCBI Phenotypes
***************

No phenotypes found linked to this gene.

.. _NCR3LG1 GO Term:

Gene Ontology
*************

* plasma membrane
* viral capsid
* integral to membrane
* structural molecule activity

.. _NCR3LG1 Pathway:

KEGG Pathways
*************

No pathways found linked to this gene.

.. _NCR3LG1 GeneRIF:

GeneRIFs
********

* The NKp30-B7-H6 structure revealed that this NK cell activating complex is distinct from the CTLA4-B7 and PD-1-PD-L T cell inhibitory complexes in both overall organization and detailed atomic interactions that mediate binding and specificity. [`PMID 21422170`_]
* Affinity Capture-MS [`PMID 21875946`_]
* DKFZp686O24166 was designated the gene B7-H6; identification as a tumor cell surface molecule that binds NKp30, a receptor which triggers antitumor NK cell cytotoxicity and cytokine secretion [`PMID 19528259`_]

.. _PMID 21422170: http://www.ncbi.nlm.nih.gov/pubmed/21422170
.. _PMID 21875946: http://www.ncbi.nlm.nih.gov/pubmed/21875946
.. _PMID 19528259: http://www.ncbi.nlm.nih.gov/pubmed/19528259

.. _NCR3LG1 Pubmed:

PubMed Articles
***************

*Recent articles:*

* Kaifu T et al. "B7-H6/NKp30 interaction: a mechanism of alerting NK cells against tumors." Cell Mol Life Sci. 2011 Nov;68(21):3531-9. `PMID 21877119`_
* Berndt JD et al. "Mindbomb 1, an E3 ubiquitin ligase, forms a complex with RYK to activate Wnt/β-catenin signaling." J Cell Biol. 2011 Sep 5;194(5):737-50. `PMID 21875946`_
* Joyce MG et al. "Crystal structure of human natural cytotoxicity receptor NKp30 and identification of its ligand binding site." Proc Natl Acad Sci U S A. 2011 Apr 12;108(15):6223-8. `PMID 21444796`_
* Li Y et al. "Structure of the human activating natural cytotoxicity receptor NKp30 bound to its tumor cell ligand B7-H6." J Exp Med. 2011 Apr 11;208(4):703-14. `PMID 21422170`_
* Brandt CS et al. "The B7 family member B7-H6 is a tumor cell ligand for the activating natural killer cell receptor NKp30 in humans." J Exp Med. 2009 Jul 6;206(7):1495-503. `PMID 19528259`_
* Strausberg RL et al. "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences." Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. `PMID 12477932`_

.. _PMID 21444796: http://www.ncbi.nlm.nih.gov/pubmed/21444796
.. _PMID 19528259: http://www.ncbi.nlm.nih.gov/pubmed/19528259
.. _PMID 21877119: http://www.ncbi.nlm.nih.gov/pubmed/21877119
.. _PMID 12477932: http://www.ncbi.nlm.nih.gov/pubmed/12477932
.. _PMID 21422170: http://www.ncbi.nlm.nih.gov/pubmed/21422170
.. _PMID 21875946: http://www.ncbi.nlm.nih.gov/pubmed/21875946