.. _NUDT5: NUDT5 ^^^^^ .. contents:: :local: General Information ******************* :Full gene name: nudix (nucleoside diphosphate linked moiety X)-type motif 5 :Entrez Gene ID: 11164 :Location: 10p14 :Synonyms: YSA1H, hYSAH1, YSA1 :Type: protein-coding User SNPs ********* SNPs given by the user that are near or inside this gene: +------------+---------------+-----------+ | SNP | Distance (bp) | Direction | +============+===============+===========+ | rs12779790 | 89867 | upstream | +------------+---------------+-----------+ .. _NUDT5 Gene summary: NCBI Summary ************ Nudix hydrolases, such as NUDT5, eliminate toxic nucleotide derivatives from the cell and regulate the levels of important signaling nucleotides and their metabolites (McLennan, 1999 [PubMed 10373642]).[supplied by OMIM, Mar 2008] .. _OMIM ID 609230 : http://omim.org/entry/609230 .. _NUDT5 OMIM Text: OMIM **** :OMIM ID: `OMIM ID 609230 `_ .. _NUDT5 Phenotype: NCBI Phenotypes *************** No phenotypes found linked to this gene. .. _NUDT5 GO Term: Gene Ontology ************* * D-ribose catabolic process * ribonucleoside diphosphate catabolic process * magnesium ion binding * nucleoside-diphosphatase activity * nucleotide metabolic process * ADP-ribose diphosphatase activity * intracellular * ADP-sugar diphosphatase activity .. _NUDT5 Pathway: KEGG Pathways ************* * `Purine metabolism `_ .. _NUDT5 GeneRIF: GeneRIFs ******** * human MTH1, MTH2, and NUDT5 proteins act as a defense against the mutagenesis induced by oxidized dGTP. [`PMID 20144704`_] * The broad substrate specificity of hNUDT5 is achieved by a diversity of not only substrate recognition, but also hydrolysis mechanisms. [`PMID 21768126`_] * NUDT5 protein eliminates various oxidized deoxyribonucleoside diphosphates from the nucleotide pool and prevents their toxic effects. [`PMID 19699693`_] * Results report the crystal structure of hNUDT5 in complex with a non-hydrolyzable ADPR analogue, alpha,beta-methyleneadenosine diphosphoribose, and three Mg(2+) ions representing the transition state of the enzyme during catalysis. [`PMID 18462755`_] * The human NUDT5, which has an intrinsic activity to cleave ADP sugars to AMP and sugar phosphate, possesses the ability to degrade 8-oxo-dGDP to the monophosphate. [`PMID 21389046`_] * degrades 8-oxo-dGDP to 8-oxo-dGMP, an unusable form for DNA synthesis, and promotes the cleavage of 8-oxo-dGTP by MTH1 to yield 8-oxo-dGMP also [`PMID 12717453`_] * Two-hybrid [`PMID 21900206`_] * Two-hybrid [`PMID 21900206`_] * Affinity Capture-MS [`PMID 20360068`_] * Results suggest that the NUDT5 protein may play significant roles in regulating the G1-S transition in HeLa cells. [`PMID 22200976`_] * Affinity Capture-MS [`PMID 21906983`_] * Two-hybrid [`PMID 16169070`_] .. _PMID 20144704: http://www.ncbi.nlm.nih.gov/pubmed/20144704 .. _PMID 21768126: http://www.ncbi.nlm.nih.gov/pubmed/21768126 .. _PMID 19699693: http://www.ncbi.nlm.nih.gov/pubmed/19699693 .. _PMID 18462755: http://www.ncbi.nlm.nih.gov/pubmed/18462755 .. _PMID 21389046: http://www.ncbi.nlm.nih.gov/pubmed/21389046 .. _PMID 12717453: http://www.ncbi.nlm.nih.gov/pubmed/12717453 .. _PMID 21900206: http://www.ncbi.nlm.nih.gov/pubmed/21900206 .. _PMID 20360068: http://www.ncbi.nlm.nih.gov/pubmed/20360068 .. _PMID 22200976: http://www.ncbi.nlm.nih.gov/pubmed/22200976 .. _PMID 21906983: http://www.ncbi.nlm.nih.gov/pubmed/21906983 .. _PMID 16169070: http://www.ncbi.nlm.nih.gov/pubmed/16169070 .. _NUDT5 Pubmed: PubMed Articles *************** *Recent articles:* * Zhang LQ et al. "Lowered nudix type 5 (NUDT5) expression leads to cell cycle retardation in HeLa cells." Mol Cell Biochem. 2012 Apr;363(1-2):377-84. `PMID 22200976`_ * Arimori T et al. "Diverse substrate recognition and hydrolysis mechanisms of human NUDT5." Nucleic Acids Res. 2011 Nov 1;39(20):8972-83. `PMID 21768126`_ * Kim W et al. "Systematic and quantitative assessment of the ubiquitin-modified proteome." Mol Cell. 2011 Oct 21;44(2):325-40. `PMID 21906983`_ * Wagner SA et al. "A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles." Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. `PMID 21890473`_ * Vinayagam A et al. "A directed protein interaction network for investigating intracellular signal transduction." Sci Signal. 2011 Sep 6;4(189):rs8. `PMID 21900206`_ * Ito R et al. "Cleavage of oxidized guanine nucleotide and ADP sugar by human NUDT5 protein." J Biochem. 2011 Jun;149(6):731-8. `PMID 21389046`_ * Danielsen JM et al. "Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level." Mol Cell Proteomics. 2011 Mar;10(3):M110.003590. `PMID 21139048`_ * Hori M et al. "Suppression of mutagenesis by 8-hydroxy-2'-deoxyguanosine 5'-triphosphate (7,8-dihydro-8-oxo-2'-deoxyguanosine 5'-triphosphate) by human MTH1, MTH2, and NUDT5." Free Radic Biol Med. 2010 May 1;48(9):1197-201. `PMID 20144704`_ * Hutchins JR et al. "Systematic analysis of human protein complexes identifies chromosome segregation proteins." Science. 2010 Apr 30;328(5978):593-9. `PMID 20360068`_ * Kamiya H et al. "NUDT5 hydrolyzes oxidized deoxyribonucleoside diphosphates with broad substrate specificity." DNA Repair (Amst). 2009 Oct 2;8(10):1250-4. `PMID 19699693`_ .. _PMID 21890473: http://www.ncbi.nlm.nih.gov/pubmed/21890473 .. _PMID 20144704: http://www.ncbi.nlm.nih.gov/pubmed/20144704 .. _PMID 21768126: http://www.ncbi.nlm.nih.gov/pubmed/21768126 .. _PMID 21900206: http://www.ncbi.nlm.nih.gov/pubmed/21900206 .. _PMID 21389046: http://www.ncbi.nlm.nih.gov/pubmed/21389046 .. _PMID 21139048: http://www.ncbi.nlm.nih.gov/pubmed/21139048 .. _PMID 19699693: http://www.ncbi.nlm.nih.gov/pubmed/19699693 .. _PMID 20360068: http://www.ncbi.nlm.nih.gov/pubmed/20360068 .. _PMID 22200976: http://www.ncbi.nlm.nih.gov/pubmed/22200976 .. _PMID 21906983: http://www.ncbi.nlm.nih.gov/pubmed/21906983 *Top Pubmed articles linked to gene NUDT5 matching any search term:* * Gasmi L et al. "Cloning, expression and characterization of YSA1H, a human adenosine 5'-diphosphosugar pyrophosphatase possessing a MutT motif." Biochem J. 1999 Dec 1;344 Pt 2:331-7. `PMID 10567213`_ .. _PMID 10567213: http://www.ncbi.nlm.nih.gov/pubmed/10567213