.. _OASL: OASL ^^^^ .. contents:: :local: General Information ******************* :Full gene name: 2'-5'-oligoadenylate synthetase-like :Entrez Gene ID: 8638 :Location: 12q24.2 :Synonyms: p59OASL, p59 OASL, p59-OASL, OASLd, TRIP14, TRIP-14 :Type: protein-coding User SNPs ********* SNPs given by the user that are near or inside this gene: +-----------+---------------+-----------+ | SNP | Distance (bp) | Direction | +===========+===============+===========+ | rs7957197 | 0 | within | +-----------+---------------+-----------+ .. _OASL Gene summary: NCBI Summary ************ None available. .. _OMIM ID 603281 : http://omim.org/entry/603281 .. _OASL OMIM Text: OMIM **** :OMIM ID: `OMIM ID 603281 `_ .. _OASL Phenotype: NCBI Phenotypes *************** * Genetic variants in LPL, OASL and TOMM40/APOE-C1-C2-C4 genes are associated with multiple cardiovascular-related traits. * Genomics meets glycomics-the first GWAS study of human N-Glycome identifies HNF1α as a master regulator of plasma protein fucosylation. * Twelve type 2 \ ``diabetes``\ susceptibility loci identified through large-scale association analysis. * NHGRI GWA Catalog .. _OASL GO Term: Gene Ontology ************* * negative regulation of viral genome replication * nucleolus * response to virus * 2'-5'-oligoadenylate synthetase activity * cytosol * cytoplasm * double-stranded RNA binding * DNA binding * ATP binding * biological_process * thyroid hormone receptor binding * type I interferon-mediated signaling pathway * interferon-gamma-mediated signaling pathway * cytokine-mediated signaling pathway .. _OASL Pathway: KEGG Pathways ************* No pathways found linked to this gene. .. _OASL GeneRIF: GeneRIFs ******** * Observational study of gene-disease association, gene-gene interaction, and gene-environment interaction. (HuGE Navigator) [`PMID 20889853`_] * Clinical trial of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator) [`PMID 19559055`_] * Affinity Capture-MS [`PMID 22586326`_] * The pronounced difference in gene regulation between the OASL gene agrees with a functional difference between these genes, which must exist as a consequence of the lack of the 2-5A synthetase activity of the OASL protein. [`PMID 19203244`_] * Proof that OASL is an antiviral protein that works through a novel mechanism distinct from other OASL proteins in other vertebrate species. [`PMID 18931074`_] * variants in LPL, OASL and TOMM40/APOE-C1-C2-C4 genes are associated with multiple cardiovascular-related traits [`PMID 21943158`_] * OASLa, a major isoform of OASL induced in human liver, may mediate anti-HCV activity through two different domains. [`PMID 20074559`_] * Observational study of gene-disease association. (HuGE Navigator) [`PMID 21050126`_] * Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator) [`PMID 20379614`_] * Affinity Capture-MS [`PMID 21987572`_] * The expression of OASL and IFIT2 was significantly higher in SLE patients than in controls. [`PMID 20506645`_] * interaction with methyl CpG-binding protein 1 was confirmed in vitro and in vivo and was mapped to the ubiquitin-like domain of p59 OASL [`PMID 14728690`_] .. _PMID 20889853: http://www.ncbi.nlm.nih.gov/pubmed/20889853 .. _PMID 19559055: http://www.ncbi.nlm.nih.gov/pubmed/19559055 .. _PMID 22586326: http://www.ncbi.nlm.nih.gov/pubmed/22586326 .. _PMID 19203244: http://www.ncbi.nlm.nih.gov/pubmed/19203244 .. _PMID 18931074: http://www.ncbi.nlm.nih.gov/pubmed/18931074 .. _PMID 21943158: http://www.ncbi.nlm.nih.gov/pubmed/21943158 .. _PMID 20074559: http://www.ncbi.nlm.nih.gov/pubmed/20074559 .. _PMID 21050126: http://www.ncbi.nlm.nih.gov/pubmed/21050126 .. _PMID 20379614: http://www.ncbi.nlm.nih.gov/pubmed/20379614 .. _PMID 21987572: http://www.ncbi.nlm.nih.gov/pubmed/21987572 .. _PMID 20506645: http://www.ncbi.nlm.nih.gov/pubmed/20506645 .. _PMID 14728690: http://www.ncbi.nlm.nih.gov/pubmed/14728690 .. _OASL Pubmed: PubMed Articles *************** *Recent articles:* * Guo X et al. "Identification of OASL d, a splice variant of human OASL, with antiviral activity." Int J Biochem Cell Biol. 2012 Jul;44(7):1133-8. `PMID 22531715`_ * Tsai YC et al. "Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcription." Mol Cell Proteomics. 2012 May;11(5):60-76. `PMID 22586326`_ * Lee KA et al. "Ubiquitin ligase substrate identification through quantitative proteomics at both the protein and peptide levels." J Biol Chem. 2011 Dec 2;286(48):41530-8. `PMID 21987572`_ * Middelberg RP et al. "Genetic variants in LPL, OASL and TOMM40/APOE-C1-C2-C4 genes are associated with multiple cardiovascular-related traits." BMC Med Genet. 2011 Sep 24;12:123. `PMID 21943158`_ * de Miguel-Yanes JM et al. "Genetic risk reclassification for type 2 diabetes by age below or above 50 years using 40 type 2 diabetes risk single nucleotide polymorphisms." Diabetes Care. 2011 Jan;34(1):121-5. `PMID 20889853`_ * Lauc G et al. "Genomics meets glycomics-the first GWAS study of human N-Glycome identifies HNF1α as a master regulator of plasma protein fucosylation." PLoS Genet. 2010 Dec 23;6(12):e1001256. `PMID 21203500`_ * Barkhash AV et al. "Variability in the 2'-5'-oligoadenylate synthetase gene cluster is associated with human predisposition to tick-borne encephalitis virus-induced disease." J Infect Dis. 2010 Dec 15;202(12):1813-8. `PMID 21050126`_ * Silva LK et al. "Dengue hemorrhagic fever is associated with polymorphisms in JAK1." Eur J Hum Genet. 2010 Nov;18(11):1221-7. `PMID 20588308`_ * Voight BF et al. "Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis." Nat Genet. 2010 Jul;42(7):579-89. `PMID 20581827`_ * Zhao ZY et al. "[Interferon-inducible genes 2', 5'-ollgoadenylate synthetase-like and tetratricopeptide repeats 2 are correlated with clinical features of patients with systemic lupus erythematosus]." Sichuan Da Xue Xue Bao Yi Xue Ban. 2010 Mar;41(2):247-51. `PMID 20506645`_ .. _PMID 21203500: http://www.ncbi.nlm.nih.gov/pubmed/21203500 .. _PMID 20581827: http://www.ncbi.nlm.nih.gov/pubmed/20581827 .. _PMID 22586326: http://www.ncbi.nlm.nih.gov/pubmed/22586326 .. _PMID 21050126: http://www.ncbi.nlm.nih.gov/pubmed/21050126 .. _PMID 21943158: http://www.ncbi.nlm.nih.gov/pubmed/21943158 .. _PMID 20889853: http://www.ncbi.nlm.nih.gov/pubmed/20889853 .. _PMID 22531715: http://www.ncbi.nlm.nih.gov/pubmed/22531715 .. _PMID 21987572: http://www.ncbi.nlm.nih.gov/pubmed/21987572 .. _PMID 20506645: http://www.ncbi.nlm.nih.gov/pubmed/20506645 .. _PMID 20588308: http://www.ncbi.nlm.nih.gov/pubmed/20588308 *Top Pubmed articles linked to gene OASL matching any search term:* * Middelberg RP et al. "Genetic variants in LPL, OASL and TOMM40/APOE-C1-C2-C4 genes are associated with multiple cardiovascular-related traits." BMC Med Genet. 2011 Sep 24;12:123. `PMID 21943158`_ * de Miguel-Yanes JM et al. "Genetic risk reclassification for type 2 diabetes by age below or above 50 years using 40 type 2 diabetes risk single nucleotide polymorphisms." Diabetes Care. 2011 Jan;34(1):121-5. `PMID 20889853`_ * Voight BF et al. "Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis." Nat Genet. 2010 Jul;42(7):579-89. `PMID 20581827`_ .. _PMID 20889853: http://www.ncbi.nlm.nih.gov/pubmed/20889853 .. _PMID 20581827: http://www.ncbi.nlm.nih.gov/pubmed/20581827 .. _PMID 21943158: http://www.ncbi.nlm.nih.gov/pubmed/21943158