.. _PDE2A: PDE2A ^^^^^ .. contents:: :local: General Information ******************* :Full gene name: phosphodiesterase 2A, cGMP-stimulated :Entrez Gene ID: 5138 :Location: 11q13.4 :Synonyms: PDE2A1, PED2A4, cGSPDE, CGS-PDE :Type: protein-coding User SNPs ********* SNPs given by the user that are near or inside this gene: +-----------+---------------+-----------+ | SNP | Distance (bp) | Direction | +===========+===============+===========+ | rs1552224 | 47604 | upstream | +-----------+---------------+-----------+ .. _PDE2A Gene summary: NCBI Summary ************ None available. .. _OMIM ID 602658 : http://omim.org/entry/602658 .. _PDE2A OMIM Text: OMIM **** :OMIM ID: `OMIM ID 602658 `_ .. _PDE2A Phenotype: NCBI Phenotypes *************** * Meta-analysis identifies nine new loci associated with rheumatoid arthritis in the Japanese population. * Genome-wide association identifies ATOH7 as a major gene determining human optic disc size. * NHGRI GWA Catalog .. _PDE2A GO Term: Gene Ontology ************* * cAMP-mediated signaling * cGMP catabolic process * protein homodimerization activity * calcium channel activity * cytosol * cytoplasm * negative regulation of cAMP biosynthetic process * metabolic process * negative regulation of protein import into nucleus, translocation * cAMP catabolic process * plasma membrane * blood coagulation * drug binding * cellular response to cGMP * cAMP binding * Golgi apparatus * protein binding * endoplasmic reticulum * cellular response to granulocyte macrophage colony-stimulating factor stimulus * TPR domain binding * establishment of endothelial barrier * metal ion binding * positive regulation of vascular permeability * perinuclear region of cytoplasm * negative regulation of transcription from RNA polymerase II promoter * cyclic-nucleotide phosphodiesterase activity * calcium ion transmembrane transport * nucleus * cGMP-stimulated cyclic-nucleotide phosphodiesterase activity * protein targeting to mitochondrion * cellular response to transforming growth factor beta stimulus * membrane raft * cGMP binding * cellular response to macrophage colony-stimulating factor stimulus * cellular response to drug * mitochondrial matrix * presynaptic membrane * positive regulation of inflammatory response * monocyte differentiation * cellular response to mechanical stimulus * cGMP-mediated signaling * negative regulation of vascular permeability .. _PDE2A Pathway: KEGG Pathways ************* * `Morphine addiction `_ * `Purine metabolism `_ .. _PDE2A GeneRIF: GeneRIFs ******** * the phosphodiesterase 2A isoform localized to mitochondria regulates respiration [`PMID 21724846`_] * Active site similarity between human and Plasmodium falciparum phosphodiesterases: considerations for antimalarial drug design [`PMID 21766240`_] * TNF-alpha-mediated up-regulation of PDE2 may destabilize endothelial barrier function in sepsis [`PMID 15650061`_] * report the X-ray crystal structures of a PDE protein that includes both catalytic and regulatory domains, namely, PDE2A containing the N-terminal GAF domains and the catalytic domain. [`PMID 19828435`_] * found in smooth muscle wall of blood vessels transversing the clitoral supepithelial and stromal space [`PMID 21697861`_] * Phosphodiesterase 2 mediates redox-sensitive endothelial cell proliferation and angiogenesis by thrombin via Rac1 and NADPH oxidase 2. [`PMID 19390057`_] * Observational study of gene-disease association. (HuGE Navigator) [`PMID 20351714`_] * Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator) [`PMID 20628086`_] * Affinity Capture-MS [`PMID 21987572`_] * Inhibition of PDE2 resulted in higher levels of intracellular cAMP than inhibition of PDE3A suggesting this PDE may be the more important regulator of cAMP in human platelets. [`PMID 12038792`_] * HIV-1 Tat decreases the intracellular levels of cAMP and CREB ser-133 phosphorylation through a signal transduction pathway involving sequential activation of phosphatidylinositol 3-kinase, AKT, and cyclic nucleoside phosphodiesterases [`PMID 11156964`_] * roles of GAF domains in mouse phosphodiesterase 2A [PDE2a] [`PMID 12271124`_] .. _PMID 21724846: http://www.ncbi.nlm.nih.gov/pubmed/21724846 .. _PMID 21766240: http://www.ncbi.nlm.nih.gov/pubmed/21766240 .. _PMID 15650061: http://www.ncbi.nlm.nih.gov/pubmed/15650061 .. _PMID 19828435: http://www.ncbi.nlm.nih.gov/pubmed/19828435 .. _PMID 21697861: http://www.ncbi.nlm.nih.gov/pubmed/21697861 .. _PMID 19390057: http://www.ncbi.nlm.nih.gov/pubmed/19390057 .. _PMID 20351714: http://www.ncbi.nlm.nih.gov/pubmed/20351714 .. _PMID 20628086: http://www.ncbi.nlm.nih.gov/pubmed/20628086 .. _PMID 21987572: http://www.ncbi.nlm.nih.gov/pubmed/21987572 .. _PMID 12038792: http://www.ncbi.nlm.nih.gov/pubmed/12038792 .. _PMID 11156964: http://www.ncbi.nlm.nih.gov/pubmed/11156964 .. _PMID 12271124: http://www.ncbi.nlm.nih.gov/pubmed/12271124 .. _PDE2A Pubmed: PubMed Articles *************** *Recent articles:* * Okada Y et al. "Meta-analysis identifies nine new loci associated with rheumatoid arthritis in the Japanese population." Nat Genet. 2012 Mar 25;44(5):511-6. `PMID 22446963`_ * Lee KA et al. "Ubiquitin ligase substrate identification through quantitative proteomics at both the protein and peptide levels." J Biol Chem. 2011 Dec 2;286(48):41530-8. `PMID 21987572`_ * Acin-Perez R et al. "A phosphodiesterase 2A isoform localized to mitochondria regulates respiration." J Biol Chem. 2011 Sep 2;286(35):30423-32. `PMID 21724846`_ * Howard BL et al. "Active site similarity between human and Plasmodium falciparum phosphodiesterases: considerations for antimalarial drug design." J Comput Aided Mol Des. 2011 Aug;25(8):753-62. `PMID 21766240`_ * Ückert S et al. "Expression and distribution of key enzymes of the cyclic GMP signaling in the human clitoris: relation to phosphodiesterase type 5 (PDE5)." Int J Impot Res. 2011 Sep-Oct;23(5):206-12. `PMID 21697861`_ * Bosker FJ et al. "Poor replication of candidate genes for major depressive disorder using genome-wide association data." Mol Psychiatry. 2011 May;16(5):516-32. `PMID 20351714`_ * Bailey SD et al. "Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study." Diabetes Care. 2010 Oct;33(10):2250-3. `PMID 20628086`_ * Macgregor S et al. "Genome-wide association identifies ATOH7 as a major gene determining human optic disc size." Hum Mol Genet. 2010 Jul 1;19(13):2716-24. `PMID 20395239`_ * Talmud PJ et al. "Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip." Am J Hum Genet. 2009 Nov;85(5):628-42. `PMID 19913121`_ * Pandit J et al. "Mechanism for the allosteric regulation of phosphodiesterase 2A deduced from the X-ray structure of a near full-length construct." Proc Natl Acad Sci U S A. 2009 Oct 27;106(43):18225-30. `PMID 19828435`_ .. _PMID 21724846: http://www.ncbi.nlm.nih.gov/pubmed/21724846 .. _PMID 21766240: http://www.ncbi.nlm.nih.gov/pubmed/21766240 .. _PMID 19828435: http://www.ncbi.nlm.nih.gov/pubmed/19828435 .. _PMID 21697861: http://www.ncbi.nlm.nih.gov/pubmed/21697861 .. _PMID 20351714: http://www.ncbi.nlm.nih.gov/pubmed/20351714 .. _PMID 20628086: http://www.ncbi.nlm.nih.gov/pubmed/20628086 .. _PMID 21987572: http://www.ncbi.nlm.nih.gov/pubmed/21987572 .. _PMID 22446963: http://www.ncbi.nlm.nih.gov/pubmed/22446963 .. _PMID 19913121: http://www.ncbi.nlm.nih.gov/pubmed/19913121 .. _PMID 20395239: http://www.ncbi.nlm.nih.gov/pubmed/20395239 *Top Pubmed articles linked to gene PDE2A matching any search term:* * Bailey SD et al. "Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study." Diabetes Care. 2010 Oct;33(10):2250-3. `PMID 20628086`_ * Favot L et al. "VEGF-induced HUVEC migration and proliferation are decreased by PDE2 and PDE4 inhibitors." Thromb Haemost. 2003 Aug;90(2):334-43. `PMID 12888882`_ .. _PMID 20628086: http://www.ncbi.nlm.nih.gov/pubmed/20628086 .. _PMID 12888882: http://www.ncbi.nlm.nih.gov/pubmed/12888882