.. _PLEKHF2:

PLEKHF2
^^^^^^^

.. contents::
   :local:

General Information
*******************

:Full gene name: pleckstrin homology domain containing, family F (with FYVE domain) member 2
:Entrez Gene ID: 79666
:Location: 8q22.1
:Synonyms: PHAFIN2, ZFYVE18
:Type: protein-coding

User SNPs
*********

SNPs given by the user that are near or inside this gene: 

+----------+---------------+-----------+
|   SNP    | Distance (bp) | Direction |
+==========+===============+===========+
| rs896854 |     185438    |  upstream |
+----------+---------------+-----------+

.. _PLEKHF2 Gene summary:

NCBI Summary
************

None available.

.. _PLEKHF2 OMIM Text:

OMIM
****

No OMIM data available for this gene.

.. _PLEKHF2 Phenotype:

NCBI Phenotypes
***************

* Radiation pharmacogenomics: a genome-wide association approach to identify radiation response biomarkers using human lymphoblastoid cell lines.
* NHGRI GWA Catalog

.. _PLEKHF2 GO Term:

Gene Ontology
*************

* protein binding
* phospholipid binding
* metal ion binding
* transport vesicle

.. _PLEKHF2 Pathway:

KEGG Pathways
*************

No pathways found linked to this gene.

.. _PLEKHF2 GeneRIF:

GeneRIFs
********

* Two-hybrid [`PMID 16189514`_]
* Two-hybrid [`PMID 16189514`_]
* Two-hybrid [`PMID 16189514`_]
* Two-hybrid [`PMID 16189514`_]
* Two-hybrid [`PMID 16189514`_]
* Two-hybrid [`PMID 16189514`_]
* Two-hybrid [`PMID 16189514`_]
* Two-hybrid [`PMID 16189514`_]
* Two-hybrid [`PMID 16189514`_]
* Two-hybrid [`PMID 16189514`_]
* Two-hybrid [`PMID 16189514`_]
* Two-hybrid [`PMID 16189514`_]
* Two-hybrid [`PMID 16189514`_]
* Two-hybrid [`PMID 16189514`_]
* Two-hybrid [`PMID 16189514`_]
* Two-hybrid [`PMID 16189514`_]
* Two-hybrid [`PMID 16189514`_]
* Two-hybrid [`PMID 16189514`_]
* Two-hybrid [`PMID 16189514`_]
* Two-hybrid [`PMID 16189514`_]
* Two-hybrid [`PMID 16189514`_]
* Results demonstrate that EAPF/Phafin-2 facilitates TNF-alpha-induced cellular apoptosis through an ER-mitochondrial apoptotic pathway. [`PMID 18288467`_]
* These results provide a vivid example that an endosome modulator, such as Phafin2, may control the cells' responses to the extracellular cues. [`PMID 19995552`_]

.. _PMID 16189514: http://www.ncbi.nlm.nih.gov/pubmed/16189514
.. _PMID 18288467: http://www.ncbi.nlm.nih.gov/pubmed/18288467
.. _PMID 19995552: http://www.ncbi.nlm.nih.gov/pubmed/19995552

.. _PLEKHF2 Pubmed:

PubMed Articles
***************

*Recent articles:*

* Niu N et al. "Radiation pharmacogenomics: a genome-wide association approach to identify radiation response biomarkers using human lymphoblastoid cell lines." Genome Res. 2010 Nov;20(11):1482-92. `PMID 20923822`_
* Lin WJ et al. "Phafin2 modulates the structure and function of endosomes by a Rab5-dependent mechanism." Biochem Biophys Res Commun. 2010 Jan 1;391(1):1043-8. `PMID 19995552`_
* Venkatesan K et al. "An empirical framework for binary interactome mapping." Nat Methods. 2009 Jan;6(1):83-90. `PMID 19060904`_
* Li C et al. "EAPF/Phafin-2, a novel endoplasmic reticulum-associated protein, facilitates TNF-alpha-triggered cellular apoptosis through endoplasmic reticulum-mitochondrial apoptotic pathway." J Mol Med (Berl). 2008 Apr;86(4):471-84. `PMID 18288467`_
* Olsen JV et al. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks." Cell. 2006 Nov 3;127(3):635-48. `PMID 17081983`_
* Mehrle A et al. "The LIFEdb database in 2006." Nucleic Acids Res. 2006 Jan 1;34(Database issue):D415-8. `PMID 16381901`_
* Rual JF et al. "Towards a proteome-scale map of the human protein-protein interaction network." Nature. 2005 Oct 20;437(7062):1173-8. `PMID 16189514`_
* Gerhard DS et al. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." Genome Res. 2004 Oct;14(10B):2121-7. `PMID 15489334`_
* Wiemann S et al. "From ORFeome to biology: a functional genomics pipeline." Genome Res. 2004 Oct;14(10B):2136-44. `PMID 15489336`_
* Ota T et al. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat Genet. 2004 Jan;36(1):40-5. `PMID 14702039`_

.. _PMID 17081983: http://www.ncbi.nlm.nih.gov/pubmed/17081983
.. _PMID 16189514: http://www.ncbi.nlm.nih.gov/pubmed/16189514
.. _PMID 14702039: http://www.ncbi.nlm.nih.gov/pubmed/14702039
.. _PMID 19995552: http://www.ncbi.nlm.nih.gov/pubmed/19995552
.. _PMID 19060904: http://www.ncbi.nlm.nih.gov/pubmed/19060904
.. _PMID 18288467: http://www.ncbi.nlm.nih.gov/pubmed/18288467
.. _PMID 20923822: http://www.ncbi.nlm.nih.gov/pubmed/20923822
.. _PMID 15489334: http://www.ncbi.nlm.nih.gov/pubmed/15489334
.. _PMID 15489336: http://www.ncbi.nlm.nih.gov/pubmed/15489336
.. _PMID 16381901: http://www.ncbi.nlm.nih.gov/pubmed/16381901

*Top Pubmed articles linked to gene PLEKHF2 matching any search term:* 

* Lin WJ et al. "Phafin2 modulates the structure and function of endosomes by a Rab5-dependent mechanism." Biochem Biophys Res Commun. 2010 Jan 1;391(1):1043-8. `PMID 19995552`_

.. _PMID 19995552: http://www.ncbi.nlm.nih.gov/pubmed/19995552