.. _PLXNB3: PLXNB3 ^^^^^^ .. contents:: :local: General Information ******************* :Full gene name: plexin B3 :Entrez Gene ID: 5365 :Location: Xq28 :Synonyms: PLEXB3, PLXN6, PLEXR :Type: protein-coding User SNPs ********* SNPs given by the user that are near or inside this gene: +-----------+---------------+-----------+ | SNP | Distance (bp) | Direction | +===========+===============+===========+ | rs3020789 | 136664 | upstream | +-----------+---------------+-----------+ .. _PLXNB3 Gene summary: NCBI Summary ************ The protein encoded by this gene is a member of the plexin family. It functions as a receptor for semaphorin 5A, and plays a role in axon guidance, invasive growth and cell migration. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009] .. _OMIM ID 300214 : http://omim.org/entry/300214 .. _PLXNB3 OMIM Text: OMIM **** :OMIM ID: `OMIM ID 300214 `_ .. _PLXNB3 Phenotype: NCBI Phenotypes *************** No phenotypes found linked to this gene. .. _PLXNB3 GO Term: Gene Ontology ************* * axon guidance * protein binding * signal transduction * integral to membrane * intracellular * receptor activity * plasma membrane .. _PLXNB3 Pathway: KEGG Pathways ************* * `Axon guidance `_ .. _PLXNB3 GeneRIF: GeneRIFs ******** * plexin B3 may influence cognitive performance, and the development of white matter in vivo in a way similar to its known stimulating effect on neurite outgrowth in vitro [`PMID 17033634`_] * Data suggest an involvement of homophilic interaction of B3 in semaphorin-independent signaling mechanisms positively influencing neuronal morphogenesis or function. [`PMID 16122393`_] * Data show that Semaphorin 5A (Sema5A) and plexin-B3 inhibit glioma cell invasion through Rac1 inactivation. [`PMID 21706053`_] * Data represent a novel signaling of semaphorin 5A and plexin B3 in the control of cell motility by indirect inactivation of Rac1 through RhoGDIalpha. [`PMID 20696765`_] * A virtual expression database search and RT-PCR analysis showed co-expression of SEMA5A and Plexin B3, and the interaction of SEMA5A with Plexin B3 was confirmed by co-immunoprecipitation studies. [`PMID 19329067`_] * Plexin-B3 is a functional receptor for semaphorin 5A [`PMID 15218527`_] * Two-hybrid [`PMID 12421765`_] * Two-hybrid [`PMID 12421765`_] * Two-hybrid [`PMID 12421765`_] * Affinity Capture-Western; Two-hybrid [`PMID 12421765`_] * Two-hybrid [`PMID 12421765`_] * Two-hybrid [`PMID 12421765`_] .. _PMID 17033634: http://www.ncbi.nlm.nih.gov/pubmed/17033634 .. _PMID 16122393: http://www.ncbi.nlm.nih.gov/pubmed/16122393 .. _PMID 21706053: http://www.ncbi.nlm.nih.gov/pubmed/21706053 .. _PMID 20696765: http://www.ncbi.nlm.nih.gov/pubmed/20696765 .. _PMID 19329067: http://www.ncbi.nlm.nih.gov/pubmed/19329067 .. _PMID 15218527: http://www.ncbi.nlm.nih.gov/pubmed/15218527 .. _PMID 12421765: http://www.ncbi.nlm.nih.gov/pubmed/12421765 .. _PLXNB3 Pubmed: PubMed Articles *************** *Recent articles:* * Li X et al. "Semaphorin 5A and plexin-B3 regulate human glioma cell motility and morphology through Rac1 and the actin cytoskeleton." Oncogene. 2012 Feb 2;31(5):595-610. `PMID 21706053`_ * Li X et al. "Semaphorin 5A and plexin-B3 inhibit human glioma cell motility through RhoGDIalpha-mediated inactivation of Rac1 GTPase." J Biol Chem. 2010 Oct 15;285(42):32436-45. `PMID 20696765`_ * Sadanandam A et al. "Identification of semaphorin 5A interacting protein by applying apriori knowledge and peptide complementarity related to protein evolution and structure." Genomics Proteomics Bioinformatics. 2008 Dec;6(3-4):163-74. `PMID 19329067`_ * Rujescu D et al. "Plexin B3 is genetically associated with verbal performance and white matter volume in human brain." Mol Psychiatry. 2007 Feb;12(2):190-4, 115. `PMID 17033634`_ * Hartwig C et al. "Plexin B3 promotes neurite outgrowth, interacts homophilically, and interacts with Rin." BMC Neurosci. 2005 Aug 25;6:53. `PMID 16122393`_ * Cheng J et al. "Transcriptional maps of 10 human chromosomes at 5-nucleotide resolution." Science. 2005 May 20;308(5725):1149-54. `PMID 15790807`_ * Conrotto P et al. "Interplay between scatter factor receptors and B plexins controls invasive growth." Oncogene. 2004 Jul 1;23(30):5131-7. `PMID 15184888`_ * Artigiani S et al. "Plexin-B3 is a functional receptor for semaphorin 5A." EMBO Rep. 2004 Jul;5(7):710-4. `PMID 15218527`_ * Perrot V et al. "Plexin B regulates Rho through the guanine nucleotide exchange factors leukemia-associated Rho GEF (LARG) and PDZ-RhoGEF." J Biol Chem. 2002 Nov 8;277(45):43115-20. `PMID 12183458`_ * Nakayama M et al. "Protein-protein interactions between large proteins: two-hybrid screening using a functionally classified library composed of long cDNAs." Genome Res. 2002 Nov;12(11):1773-84. `PMID 12421765`_ .. _PMID 17033634: http://www.ncbi.nlm.nih.gov/pubmed/17033634 .. _PMID 16122393: http://www.ncbi.nlm.nih.gov/pubmed/16122393 .. _PMID 21706053: http://www.ncbi.nlm.nih.gov/pubmed/21706053 .. _PMID 20696765: http://www.ncbi.nlm.nih.gov/pubmed/20696765 .. _PMID 15184888: http://www.ncbi.nlm.nih.gov/pubmed/15184888 .. _PMID 19329067: http://www.ncbi.nlm.nih.gov/pubmed/19329067 .. _PMID 15790807: http://www.ncbi.nlm.nih.gov/pubmed/15790807 .. _PMID 15218527: http://www.ncbi.nlm.nih.gov/pubmed/15218527 .. _PMID 12421765: http://www.ncbi.nlm.nih.gov/pubmed/12421765 .. _PMID 12183458: http://www.ncbi.nlm.nih.gov/pubmed/12183458