.. _PNCK:

PNCK
^^^^

.. contents::
   :local:

General Information
*******************

:Full gene name: pregnancy up-regulated non-ubiquitously expressed CaM kinase
:Entrez Gene ID: 139728
:Location: Xq28
:Synonyms: BSTK3, CaMK1b
:Type: protein-coding

User SNPs
*********

SNPs given by the user that are near or inside this gene: 

+-----------+---------------+------------+
|    SNP    | Distance (bp) | Direction  |
+===========+===============+============+
| rs3020789 |     42201     | downstream |
+-----------+---------------+------------+

.. _PNCK Gene summary:

NCBI Summary
************

PNCK is a member of the calcium/calmodulin-dependent protein kinase family of protein serine/threonine kinases (see CAMK1; MIM 604998) (Gardner et al., 2000 [PubMed 10673339]).[supplied by OMIM, Mar 2008]

.. _OMIM ID 300680
                        : http://omim.org/entry/300680
                        

.. _PNCK OMIM Text:

OMIM
****

:OMIM ID: `OMIM ID 300680
                        `_


.. _PNCK Phenotype:

NCBI Phenotypes
***************

No phenotypes found linked to this gene.

.. _PNCK GO Term:

Gene Ontology
*************

* cytoplasm
* calmodulin binding
* nucleus
* ATP binding
* calmodulin-dependent protein kinase activity

.. _PNCK Pathway:

KEGG Pathways
*************

No pathways found linked to this gene.

.. _PNCK GeneRIF:

GeneRIFs
********

* Pnck induces epidermal growth factor receptor degradation, most likely through perturbation of Hsp90 chaperone activity due to Hsp90 phosphorylation. Epidermal growth factor receptor degradation is coupled to proteasomal degradation of Pnck. [`PMID 21325639`_]
* Pnck induces ligand-independent EGFR degradation, and it may represent an attractive therapeutic target in EGFR-regulated oncogenesis. [`PMID 18562482`_]

.. _PMID 21325639: http://www.ncbi.nlm.nih.gov/pubmed/21325639
.. _PMID 18562482: http://www.ncbi.nlm.nih.gov/pubmed/18562482

.. _PNCK Pubmed:

PubMed Articles
***************

*Recent articles:*

* Deb TB et al. "Pnck induces ligand-independent EGFR degradation by probable perturbation of the Hsp90 chaperone complex." Am J Physiol Cell Physiol. 2011 May;300(5):C1139-54. `PMID 21325639`_
* Deb TB et al. "Pregnancy-upregulated nonubiquitous calmodulin kinase induces ligand-independent EGFR degradation." Am J Physiol Cell Physiol. 2008 Aug;295(2):C365-77. `PMID 18562482`_
* Barbe L et al. "Toward a confocal subcellular atlas of the human proteome." Mol Cell Proteomics. 2008 Mar;7(3):499-508. `PMID 18029348`_
* Gerhard DS et al. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." Genome Res. 2004 Oct;14(10B):2121-7. `PMID 15489334`_
* Strausberg RL et al. "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences." Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. `PMID 12477932`_
* Gardner HP et al. "The caM kinase, Pnck, is spatially and temporally regulated during murine mammary gland development and may identify an epithelial cell subtype involved in breast cancer." Cancer Res. 2000 Oct 1;60(19):5571-7. `PMID 11034105`_
* Gardner HP et al. "Cloning, characterization, and chromosomal localization of Pnck, a Ca(2+)/calmodulin-dependent protein kinase." Genomics. 2000 Jan 15;63(2):279-88. `PMID 10673339`_
* Bonaldo MF et al. "Normalization and subtraction: two approaches to facilitate gene discovery." Genome Res. 1996 Sep;6(9):791-806. `PMID 8889548`_

.. _PMID 18562482: http://www.ncbi.nlm.nih.gov/pubmed/18562482
.. _PMID 21325639: http://www.ncbi.nlm.nih.gov/pubmed/21325639
.. _PMID 12477932: http://www.ncbi.nlm.nih.gov/pubmed/12477932
.. _PMID 11034105: http://www.ncbi.nlm.nih.gov/pubmed/11034105
.. _PMID 18029348: http://www.ncbi.nlm.nih.gov/pubmed/18029348
.. _PMID 10673339: http://www.ncbi.nlm.nih.gov/pubmed/10673339
.. _PMID 8889548: http://www.ncbi.nlm.nih.gov/pubmed/8889548
.. _PMID 15489334: http://www.ncbi.nlm.nih.gov/pubmed/15489334

*Top Pubmed articles linked to gene PNCK matching any search term:* 

* Witczak CA et al. "Ca2+/calmodulin-dependent protein kinase kinase-alpha regulates skeletal muscle glucose uptake independent of AMP-activated protein kinase and Akt activation." Diabetes. 2007 May;56(5):1403-9. `PMID 17287469`_
* Gardner HP et al. "Cloning, characterization, and chromosomal localization of Pnck, a Ca(2+)/calmodulin-dependent protein kinase." Genomics. 2000 Jan 15;63(2):279-88. `PMID 10673339`_
* Yang JM et al. "Increased expression of Galphaq protein in the heart of streptozotocin-induced diabetic rats." Exp Mol Med. 1999 Dec 31;31(4):179-84. `PMID 10630371`_

.. _PMID 17287469: http://www.ncbi.nlm.nih.gov/pubmed/17287469
.. _PMID 10630371: http://www.ncbi.nlm.nih.gov/pubmed/10630371
.. _PMID 10673339: http://www.ncbi.nlm.nih.gov/pubmed/10673339