.. _PPP2R2C: PPP2R2C ^^^^^^^ .. contents:: :local: General Information ******************* :Full gene name: protein phosphatase 2, regulatory subunit B, gamma :Entrez Gene ID: 5522 :Location: 4p16.1 :Synonyms: IMYPNO1, B55-GAMMA, IMYPNO, PR55G, PR52 :Type: protein-coding User SNPs ********* SNPs given by the user that are near or inside this gene: +------------+---------------+------------+ | SNP | Distance (bp) | Direction | +============+===============+============+ | rs10010131 | 29390 | downstream | +------------+---------------+------------+ .. _PPP2R2C Gene summary: NCBI Summary ************ The product of this gene belongs to the phosphatase 2 regulatory subunit B family. Protein phosphatase 2 is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. The B regulatory subunit might modulate substrate selectivity and catalytic activity. This gene encodes a gamma isoform of the regulatory subunit B55 subfamily. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008] .. _OMIM ID 605997 : http://omim.org/entry/605997 .. _PPP2R2C OMIM Text: OMIM **** :OMIM ID: `OMIM ID 605997 `_ .. _PPP2R2C Phenotype: NCBI Phenotypes *************** * NHGRI GWA Catalog * Genetic variant near IRS1 is associated with type 2 \ ``diabetes``\ , \ ``insulin``\ resistance and hyper\ ``insulin``\ emia. .. _PPP2R2C GO Term: Gene Ontology ************* * signal transduction * protein phosphatase type 2A regulator activity * protein phosphatase type 2A complex .. _PPP2R2C Pathway: KEGG Pathways ************* * `Chagas disease (American trypanosomiasis) `_ * `Dopaminergic synapse `_ * `mRNA surveillance pathway `_ * `Tight junction `_ * `Hepatitis C `_ .. _PPP2R2C GeneRIF: GeneRIFs ******** * HIV-1 Vpr forms a complex with HIV-1 nucleocapsid that directly activates PP2A [`PMID 9013886`_] * HIV-1 Vpr forms a complex with HIV-1 nucleocapsid that directly activates PP2A [`PMID 9013886`_] * specific PP2A complexes involved in human cell transformation [`PMID 14998489`_] * Affinity Capture-MS [`PMID 21906983`_] * Protein phosphatase-2A (PP2A) and protein phosphatase-1 (PP1) regulate HIV-1 Tat-activated transcription through dephosphorylation of CDK9 [`PMID 16048649`_] * RAF1 (c-Raf) interacts with an unspecified isoform of PPP2R2C (PP2A-C). [`PMID 16041367`_] * HIV-1 Vpr was reported to mediate G2 arrest by forming a complex with PP2A through binding to the B55 regulatory subunit, thereby targeting the complex to the nucleus and enhancing cdc25 dephosphorylation, however the paper was subsequently retracted [`PMID 15817944`_] * Affinity Capture-MS [`PMID 19156129`_] * Affinity Capture-MS [`PMID 19156129`_] * Affinity Capture-MS [`PMID 19156129`_] * Affinity Capture-MS [`PMID 19156129`_] * Affinity Capture-MS [`PMID 19156129`_] * Affinity Capture-MS [`PMID 19156129`_] * Affinity Capture-MS [`PMID 19156129`_] * Affinity Capture-MS [`PMID 19156129`_] * Affinity Capture-MS [`PMID 19156129`_] * Affinity Capture-MS [`PMID 19156129`_] * Affinity Capture-MS [`PMID 19156129`_] * Affinity Capture-MS [`PMID 19156129`_] * Affinity Capture-MS [`PMID 19156129`_] * Affinity Capture-MS [`PMID 19156129`_] * Affinity Capture-MS [`PMID 19156129`_] * Affinity Capture-MS [`PMID 19156129`_] * Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator) [`PMID 20379614`_] * HIV-1 Vpr cell death causing peptide (amino acid residues 71-96) can activate the expression of PP2A when applied extracellularly to CD4+ T cells as well as cause the activation of PP2A from brain, liver, and adipose tissues [`PMID 15638722`_] * HIV-1 Vpr was found to upregulate PP2A in fission yeast [`PMID 11531413`_] * Affinity Capture-MS [`PMID 21822214`_] * Co-purification [`PMID 12912990`_] * novel mechanism of c-SRC regulation whereby in response to stress c-SRC activity is regulated, at least in part, through loss of the interaction with its inhibitor, PR55gamma [`PMID 18069897`_] * encoding a subunit of proteinphosphatase 2A with a unique expression pattern in brain and a role in synaptic plasticity [`PMID 20601260`_] * Observational study and genome-wide association study of gene-disease association. (HuGE Navigator) [`PMID 20308991`_] * An increase in the amount of PP2A core enzyme with a concomitant decrease in the amount of PP2A holoenzyme inhibits HIV-1 Tat-stimulated transcription from the HIV-1 LTR promoter, indicating a role for PP2A in the modulation of HIV-1 gene expression [`PMID 9400615`_] .. _PMID 9013886: http://www.ncbi.nlm.nih.gov/pubmed/9013886 .. _PMID 14998489: http://www.ncbi.nlm.nih.gov/pubmed/14998489 .. _PMID 21906983: http://www.ncbi.nlm.nih.gov/pubmed/21906983 .. _PMID 16048649: http://www.ncbi.nlm.nih.gov/pubmed/16048649 .. _PMID 16041367: http://www.ncbi.nlm.nih.gov/pubmed/16041367 .. _PMID 15817944: http://www.ncbi.nlm.nih.gov/pubmed/15817944 .. _PMID 19156129: http://www.ncbi.nlm.nih.gov/pubmed/19156129 .. _PMID 20379614: http://www.ncbi.nlm.nih.gov/pubmed/20379614 .. _PMID 15638722: http://www.ncbi.nlm.nih.gov/pubmed/15638722 .. _PMID 11531413: http://www.ncbi.nlm.nih.gov/pubmed/11531413 .. _PMID 21822214: http://www.ncbi.nlm.nih.gov/pubmed/21822214 .. _PMID 12912990: http://www.ncbi.nlm.nih.gov/pubmed/12912990 .. _PMID 18069897: http://www.ncbi.nlm.nih.gov/pubmed/18069897 .. _PMID 20601260: http://www.ncbi.nlm.nih.gov/pubmed/20601260 .. _PMID 20308991: http://www.ncbi.nlm.nih.gov/pubmed/20308991 .. _PMID 9400615: http://www.ncbi.nlm.nih.gov/pubmed/9400615 .. _PPP2R2C Pubmed: PubMed Articles *************** *Recent articles:* * Kim W et al. "Systematic and quantitative assessment of the ubiquitin-modified proteome." Mol Cell. 2011 Oct 21;44(2):325-40. `PMID 21906983`_ * Oellerich T et al. "The B-cell antigen receptor signals through a preformed transducer module of SLP65 and CIN85." EMBO J. 2011 Aug 5;30(17):3620-34. `PMID 21822214`_ * Kim S et al. "Integrative genome-wide association analysis of cytoarchitectural abnormalities in the prefrontal cortex of psychiatric disorders." Mol Psychiatry. 2011 Apr;16(4):452-61. `PMID 20308991`_ * Backx L et al. "PPP2R2C, a gene disrupted in autosomal dominant intellectual disability." Eur J Med Genet. 2010 Sep-Oct;53(5):239-43. `PMID 20601260`_ * Rose JE et al. "Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score." Mol Med. 2010 Jul-Aug;16(7-8):247-53. `PMID 20379614`_ * Rung J et al. "Genetic variant near IRS1 is associated with type 2 diabetes, insulin resistance and hyperinsulinemia." Nat Genet. 2009 Oct;41(10):1110-5. `PMID 19734900`_ * Glatter T et al. "An integrated workflow for charting the human interaction proteome: insights into the PP2A system." Mol Syst Biol. 2009;5:237. `PMID 19156129`_ * Goudreault M et al. "A PP2A phosphatase high density interaction network identifies a novel striatin-interacting phosphatase and kinase complex linked to the cerebral cavernous malformation 3 (CCM3) protein." Mol Cell Proteomics. 2009 Jan;8(1):157-71. `PMID 18782753`_ * Eichhorn PJ et al. "A RNA interference screen identifies the protein phosphatase 2A subunit PR55gamma as a stress-sensitive inhibitor of c-SRC." PLoS Genet. 2007 Dec;3(12):e218. `PMID 18069897`_ * Ammosova T et al. "Dephosphorylation of CDK9 by protein phosphatase 2A and protein phosphatase-1 in Tat-activated HIV-1 transcription." Retrovirology. 2005 Jul 27;2:47. `PMID 16048649`_ .. _PMID 19156129: http://www.ncbi.nlm.nih.gov/pubmed/19156129 .. _PMID 21906983: http://www.ncbi.nlm.nih.gov/pubmed/21906983 .. _PMID 16048649: http://www.ncbi.nlm.nih.gov/pubmed/16048649 .. _PMID 19734900: http://www.ncbi.nlm.nih.gov/pubmed/19734900 .. _PMID 18782753: http://www.ncbi.nlm.nih.gov/pubmed/18782753 .. _PMID 20379614: http://www.ncbi.nlm.nih.gov/pubmed/20379614 .. _PMID 21822214: http://www.ncbi.nlm.nih.gov/pubmed/21822214 .. _PMID 18069897: http://www.ncbi.nlm.nih.gov/pubmed/18069897 .. _PMID 20601260: http://www.ncbi.nlm.nih.gov/pubmed/20601260 .. _PMID 20308991: http://www.ncbi.nlm.nih.gov/pubmed/20308991 *Top Pubmed articles linked to gene PPP2R2C matching any search term:* * Rung J et al. "Genetic variant near IRS1 is associated with type 2 diabetes, insulin resistance and hyperinsulinemia." Nat Genet. 2009 Oct;41(10):1110-5. `PMID 19734900`_ .. _PMID 19734900: http://www.ncbi.nlm.nih.gov/pubmed/19734900