.. _REG4: REG4 ^^^^ .. contents:: :local: General Information ******************* :Full gene name: regenerating islet-derived family, member 4 :Entrez Gene ID: 83998 :Location: 1p13.1-p12 :Synonyms: GISP, RELP, REG-IV :Type: protein-coding User SNPs ********* SNPs given by the user that are near or inside this gene: +------------+---------------+-----------+ | SNP | Distance (bp) | Direction | +============+===============+===========+ | rs10923931 | 163756 | upstream | +------------+---------------+-----------+ .. _REG4 Gene summary: NCBI Summary ************ None available. .. _OMIM ID 609846 : http://omim.org/entry/609846 .. _REG4 OMIM Text: OMIM **** :OMIM ID: `OMIM ID 609846 `_ .. _REG4 Phenotype: NCBI Phenotypes *************** No phenotypes found linked to this gene. .. _REG4 GO Term: Gene Ontology ************* * extracellular region * carbohydrate binding .. _REG4 Pathway: KEGG Pathways ************* No pathways found linked to this gene. .. _REG4 GeneRIF: GeneRIFs ******** * Overexpression of REGIV mRNA is assessed with peritoneal recurrence in gastric adenocarcinoma. [`PMID 21780125`_] * REG4 may play an important role in the development and progression of colorectal cancer, as well as in intestinal morphogenesis and epithelium restitution [`PMID 20126989`_] * Increased expression of Reg IV is associated wirh hormone refractory metastatic prostate cancer [`PMID 15788672`_] * The solution structure of hRegIV-P91S was determined, showing that it adopts a typical fold of C-type lectin. Based on the chemical shift perturbations of amide resonances, two calcium-independent mannan-binding sites were proposed [`PMID 20692269`_] * Reg IV expression experienced up-regulation in gastric intestinal metaplasia and adenoma and then down-regulation with malignant transformation of gastric epithelial cells. [`PMID 19740514`_] * Reg IV staining can aid in diagnosis of gastrointestinal signet ring cell carcinoma. [`PMID 18580680`_] * REG4 is expressed in pancreatic cancer, and serum levels of REG4 offer a useful indicator for distinguishing between patients with pancreatic cancer and healthy subjects [`PMID 19789838`_] * REG4 may be a prognostic indicator and a better serum marker than carcinoembryonic antigen and carbohydrate antigen 19-9 for early diagnosis of gastric cancer. [`PMID 21419474`_] * Reg IV is a potent activator of the EGF receptor/Akt/AP-1 signaling pathway in colorectal carcinoma [`PMID 16401477`_] * Reg IV might accelerate cell growth and disease progression of adenoid cystic carcinomas . [`PMID 19076683`_] * RegIV expression was markedly higher in gastric cancer patients with peritoneal metastases compared to those without; level of RegIV mRNA in gastric cancer patients was related to the extent of wall penetration [`PMID 18505053`_] * Reg IV might accelerate peritoneal metastasis in gastric cancer. Reg IV in lavage fluids might be a good marker for peritoneal metastasis [`PMID 19143768`_] * Data demonstrated in vitro and in vivo that REG4 protein overexpression was associated with an unfavorable response to preoperative chemoradiotherapy. [`PMID 19546835`_] * Knockdown of Reg IV impacted the ability of \ ``insulin``\ and EGF to stimulate downstream tyrosine phosphorylation. [`PMID 21445968`_] * Local Reg IV expression may be influenced by the growth factors basic fibroblast growth factor and somatotropin and dtheri receptors [`PMID 19924642`_] * reg4 is amplified in the early stages of pancreatic cancer development [`PMID 19834624`_] * RELP serves as a marker for appendiceal mucinous cystadenomas and pseudomyxoma peritonei and may contribute to the pathogenesis of these disorders. [`PMID 16323007`_] * overexpression of Reg IV may be an early event in colorectal carcinogenesis. [`PMID 14550954`_] * RegIV is expressed in the gastrointestinal tract and in digestive tract neuroendocrine tumor [`PMID 20349522`_] * RegIV enhances LoVo cell migration and invasion, and its CRD domain is critical for these effects. [`PMID 20417867`_] * REG IV overexpression may be an early event in colorectal carcinoma carcinogenesis. [`PMID 20183800`_] * Reg IV as an important modulator of gastrointestinal cell susceptibility to irradiation; hence, it is a potential target for adjunctive treatments for human colorectal cancer and other gastrointestinal malignancies. [`PMID 19900450`_] * These results suggest that Reg IV expression is an independent prognostic indicator of relapse after radical prostatectomy. [`PMID 18754868`_] * REG4, BIRC5 and NEIL2 genes might have a role in the sensitivity of cancer patients to radiotherapy [`PMID 22199273`_] * Reg IV is involved in gallbladder carcinoma carcinogenesis through intestinal metaplasia and is associated with relatively favorable prognosis in patients after surgery [`PMID 19716164`_] * Overexpression of REG4 is associated with pancreatic cancer [`PMID 16918991`_] * among major urologic cancers, Reg IV is expressed frequently in prostate cancer, and that serum Reg IV represents a novel biomarker for prostate cancer [`PMID 19082448`_] * Expression of REG Ialpha but not REG IV was an independent predictor of poor outcome in patients with gastric cancer. [`PMID 19329938`_] * serum Reg IV concentration may predict metastatic recurrence of colorectal cancer in the liver.Reg IV protein expression induced by growth factors may function as a growth-promoting and/or an antiapoptotic factor in the peritumoral mucosa of CRC. [`PMID 18187959`_] * Results suggest that RELP might be involved in inflammatory and metaplastic responses of the gastrointestinal epithelium. [`PMID 12819006`_] * REG4 is involved in the 'intestinal' pathway of carcinogenesis in intraductal papillary mucinous neoplasms of the pancreas [`PMID 19136934`_] * GLI1 promotes RegIV transcription by binding to the RegIV gene promoter in pancreatic cancer. [`PMID 21494603`_] .. _PMID 21780125: http://www.ncbi.nlm.nih.gov/pubmed/21780125 .. _PMID 20126989: http://www.ncbi.nlm.nih.gov/pubmed/20126989 .. _PMID 15788672: http://www.ncbi.nlm.nih.gov/pubmed/15788672 .. _PMID 20692269: http://www.ncbi.nlm.nih.gov/pubmed/20692269 .. _PMID 19740514: http://www.ncbi.nlm.nih.gov/pubmed/19740514 .. _PMID 18580680: http://www.ncbi.nlm.nih.gov/pubmed/18580680 .. _PMID 19789838: http://www.ncbi.nlm.nih.gov/pubmed/19789838 .. _PMID 21419474: http://www.ncbi.nlm.nih.gov/pubmed/21419474 .. _PMID 16401477: http://www.ncbi.nlm.nih.gov/pubmed/16401477 .. _PMID 19076683: http://www.ncbi.nlm.nih.gov/pubmed/19076683 .. _PMID 18505053: http://www.ncbi.nlm.nih.gov/pubmed/18505053 .. _PMID 19143768: http://www.ncbi.nlm.nih.gov/pubmed/19143768 .. _PMID 19546835: http://www.ncbi.nlm.nih.gov/pubmed/19546835 .. _PMID 21445968: http://www.ncbi.nlm.nih.gov/pubmed/21445968 .. _PMID 19924642: http://www.ncbi.nlm.nih.gov/pubmed/19924642 .. _PMID 19834624: http://www.ncbi.nlm.nih.gov/pubmed/19834624 .. _PMID 16323007: http://www.ncbi.nlm.nih.gov/pubmed/16323007 .. _PMID 14550954: http://www.ncbi.nlm.nih.gov/pubmed/14550954 .. _PMID 20349522: http://www.ncbi.nlm.nih.gov/pubmed/20349522 .. _PMID 20417867: http://www.ncbi.nlm.nih.gov/pubmed/20417867 .. _PMID 20183800: http://www.ncbi.nlm.nih.gov/pubmed/20183800 .. _PMID 19900450: http://www.ncbi.nlm.nih.gov/pubmed/19900450 .. _PMID 18754868: http://www.ncbi.nlm.nih.gov/pubmed/18754868 .. _PMID 22199273: http://www.ncbi.nlm.nih.gov/pubmed/22199273 .. _PMID 19716164: http://www.ncbi.nlm.nih.gov/pubmed/19716164 .. _PMID 16918991: http://www.ncbi.nlm.nih.gov/pubmed/16918991 .. _PMID 19082448: http://www.ncbi.nlm.nih.gov/pubmed/19082448 .. _PMID 19329938: http://www.ncbi.nlm.nih.gov/pubmed/19329938 .. _PMID 18187959: http://www.ncbi.nlm.nih.gov/pubmed/18187959 .. _PMID 12819006: http://www.ncbi.nlm.nih.gov/pubmed/12819006 .. _PMID 19136934: http://www.ncbi.nlm.nih.gov/pubmed/19136934 .. _PMID 21494603: http://www.ncbi.nlm.nih.gov/pubmed/21494603 .. _REG4 Pubmed: PubMed Articles *************** *Recent articles:* * Vanderlaag K et al. "Regenerating islet-derived family member, 4 modulates multiple receptor tyrosine kinases and mediators of drug resistance in cancer." Int J Cancer. 2012 Mar 15;130(6):1251-63. `PMID 21445968`_ * Moon JH et al. "REGIV as a potential biomarker for peritoneal dissemination in gastric adenocarcinoma." J Surg Oncol. 2012 Feb;105(2):189-94. `PMID 21780125`_ * Kobunai T et al. "REG4, NEIL2, and BIRC5 gene expression correlates with gamma-radiation sensitivity in patients with rectal cancer receiving radiotherapy." Anticancer Res. 2011 Dec;31(12):4147-53. `PMID 22199273`_ * Tao HQ et al. "Evaluation of REG4 for early diagnosis and prognosis of gastric cancer." Hum Pathol. 2011 Oct;42(10):1401-9. `PMID 21419474`_ * Wang F et al. "Identification of RegIV as a novel GLI1 target gene in human pancreatic cancer." PLoS One. 2011 Apr 11;6(4):e18434. `PMID 21494603`_ * Ho MR et al. "Human RegIV protein adopts a typical C-type lectin fold but binds mannan with two calcium-independent sites." J Mol Biol. 2010 Oct 1;402(4):682-95. `PMID 20692269`_ * Guo Y et al. "RegIV potentiates colorectal carcinoma cell migration and invasion via its CRD domain." Cancer Genet Cytogenet. 2010 May;199(1):38-44. `PMID 20417867`_ * Li FY et al. "RegIV expression showing specificity to gastrointestinal tract and its potential role in diagnosing digestive tract neuroendocrine tumor." J Zhejiang Univ Sci B. 2010 Apr;11(4):258-66. `PMID 20349522`_ * Li XH et al. "REG IV overexpression in an early stage of colorectal carcinogenesis: an immunohistochemical study." Histol Histopathol. 2010 Apr;25(4):473-84. `PMID 20183800`_ * Rafa L et al. "REG4 acts as a mitogenic, motility and pro-invasive factor for colon cancer cells." Int J Oncol. 2010 Mar;36(3):689-98. `PMID 20126989`_ .. _PMID 21780125: http://www.ncbi.nlm.nih.gov/pubmed/21780125 .. _PMID 20126989: http://www.ncbi.nlm.nih.gov/pubmed/20126989 .. _PMID 21419474: http://www.ncbi.nlm.nih.gov/pubmed/21419474 .. _PMID 20349522: http://www.ncbi.nlm.nih.gov/pubmed/20349522 .. _PMID 20692269: http://www.ncbi.nlm.nih.gov/pubmed/20692269 .. _PMID 20417867: http://www.ncbi.nlm.nih.gov/pubmed/20417867 .. _PMID 20183800: http://www.ncbi.nlm.nih.gov/pubmed/20183800 .. _PMID 21494603: http://www.ncbi.nlm.nih.gov/pubmed/21494603 .. _PMID 21445968: http://www.ncbi.nlm.nih.gov/pubmed/21445968 .. _PMID 22199273: http://www.ncbi.nlm.nih.gov/pubmed/22199273 *Top Pubmed articles linked to gene REG4 matching any search term:* * Vanderlaag K et al. "Regenerating islet-derived family member, 4 modulates multiple receptor tyrosine kinases and mediators of drug resistance in cancer." Int J Cancer. 2012 Mar 15;130(6):1251-63. `PMID 21445968`_ * Iglesias-García J et al. "[Pancreatic tumors]." Gastroenterol Hepatol. 2008 Oct;31 Suppl 4:83-92. `PMID 19434873`_ * Oue N et al. "Expression and localization of Reg IV in human neoplastic and non-neoplastic tissues: Reg IV expression is associated with intestinal and neuroendocrine differentiation in gastric adenocarcinoma." J Pathol. 2005 Oct;207(2):185-98. `PMID 16086444`_ * Zhang YW et al. "Reg gene family and human diseases." World J Gastroenterol. 2003 Dec;9(12):2635-41. `PMID 14669303`_ .. _PMID 19434873: http://www.ncbi.nlm.nih.gov/pubmed/19434873 .. _PMID 14669303: http://www.ncbi.nlm.nih.gov/pubmed/14669303 .. _PMID 16086444: http://www.ncbi.nlm.nih.gov/pubmed/16086444 .. _PMID 21445968: http://www.ncbi.nlm.nih.gov/pubmed/21445968