.. _SEC61A2: SEC61A2 ^^^^^^^ .. contents:: :local: General Information ******************* :Full gene name: Sec61 alpha 2 subunit (S. cerevisiae) :Entrez Gene ID: 55176 :Location: 10p14 :Synonyms: :Type: protein-coding User SNPs ********* SNPs given by the user that are near or inside this gene: +------------+---------------+------------+ | SNP | Distance (bp) | Direction | +============+===============+============+ | rs12779790 | 116053 | downstream | +------------+---------------+------------+ .. _SEC61A2 Gene summary: NCBI Summary ************ The protein encoded by this gene has similarity to a mouse protein which suggests a role in the insertion of secretory and membrane polypeptides into the endoplasmic reticulum. It may also be required for the assembly of membrane and secretory proteins. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2008] .. _SEC61A2 OMIM Text: OMIM **** No OMIM data available for this gene. .. _SEC61A2 Phenotype: NCBI Phenotypes *************** No phenotypes found linked to this gene. .. _SEC61A2 GO Term: Gene Ontology ************* * endoplasmic reticulum membrane * molecular_function * antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent * phagocytic vesicle membrane * antigen processing and presentation of peptide antigen via MHC class I * P-P-bond-hydrolysis-driven protein transmembrane transporter activity * ribosome binding * integral to membrane * biological_process * antigen processing and presentation of exogenous peptide antigen via MHC class I .. _SEC61A2 Pathway: KEGG Pathways ************* * `Protein processing in endoplasmic reticulum `_ * `Vibrio cholerae infection `_ * `Phagosome `_ * `Protein export `_ .. _SEC61A2 GeneRIF: GeneRIFs ******** * Affinity Capture-MS [`PMID 20562859`_] * Observational study of gene-disease association. (HuGE Navigator) [`PMID 16385451`_] * Affinity Capture-MS [`PMID 21987572`_] * Affinity Capture-MS [`PMID 19615732`_] .. _PMID 20562859: http://www.ncbi.nlm.nih.gov/pubmed/20562859 .. _PMID 16385451: http://www.ncbi.nlm.nih.gov/pubmed/16385451 .. _PMID 21987572: http://www.ncbi.nlm.nih.gov/pubmed/21987572 .. _PMID 19615732: http://www.ncbi.nlm.nih.gov/pubmed/19615732 .. _SEC61A2 Pubmed: PubMed Articles *************** *Recent articles:* * Lee KA et al. "Ubiquitin ligase substrate identification through quantitative proteomics at both the protein and peptide levels." J Biol Chem. 2011 Dec 2;286(48):41530-8. `PMID 21987572`_ * Kim W et al. "Systematic and quantitative assessment of the ubiquitin-modified proteome." Mol Cell. 2011 Oct 21;44(2):325-40. `PMID 21906983`_ * Wagner SA et al. "A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles." Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. `PMID 21890473`_ * Behrends C et al. "Network organization of the human autophagy system." Nature. 2010 Jul 1;466(7302):68-76. `PMID 20562859`_ * Sowa ME et al. "Defining the human deubiquitinating enzyme interaction landscape." Cell. 2009 Jul 23;138(2):389-403. `PMID 19615732`_ * Grupe A et al. "A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease." Am J Hum Genet. 2006 Jan;78(1):78-88. `PMID 16385451`_ * Suzuki Y et al. "Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions." Genome Res. 2004 Sep;14(9):1711-8. `PMID 15342556`_ * Ota T et al. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat Genet. 2004 Jan;36(1):40-5. `PMID 14702039`_ * Strausberg RL et al. "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences." Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. `PMID 12477932`_ * Kawai J et al. "Functional annotation of a full-length mouse cDNA collection." Nature. 2001 Feb 8;409(6821):685-90. `PMID 11217851`_ .. _PMID 21890473: http://www.ncbi.nlm.nih.gov/pubmed/21890473 .. _PMID 14702039: http://www.ncbi.nlm.nih.gov/pubmed/14702039 .. _PMID 12477932: http://www.ncbi.nlm.nih.gov/pubmed/12477932 .. _PMID 15342556: http://www.ncbi.nlm.nih.gov/pubmed/15342556 .. _PMID 21987572: http://www.ncbi.nlm.nih.gov/pubmed/21987572 .. _PMID 19615732: http://www.ncbi.nlm.nih.gov/pubmed/19615732 .. _PMID 16385451: http://www.ncbi.nlm.nih.gov/pubmed/16385451 .. _PMID 20562859: http://www.ncbi.nlm.nih.gov/pubmed/20562859 .. _PMID 21906983: http://www.ncbi.nlm.nih.gov/pubmed/21906983 .. _PMID 11217851: http://www.ncbi.nlm.nih.gov/pubmed/11217851 *Top Pubmed articles linked to gene SEC61A2 matching any search term:* * Dodson G et al. "The role of assembly in insulin's biosynthesis." Curr Opin Struct Biol. 1998 Apr;8(2):189-94. `PMID 9631292`_ .. _PMID 9631292: http://www.ncbi.nlm.nih.gov/pubmed/9631292