.. _SENP2:

SENP2
^^^^^

.. contents::
   :local:

General Information
*******************

:Full gene name: SUMO1/sentrin/SMT3 specific peptidase 2
:Entrez Gene ID: 59343
:Location: 3q27.2
:Synonyms: AXAM2, SMT3IP2
:Type: protein-coding

User SNPs
*********

SNPs given by the user that are near or inside this gene: 

+-----------+---------------+------------+
|    SNP    | Distance (bp) | Direction  |
+===========+===============+============+
| rs1470579 |     180195    | downstream |
+-----------+---------------+------------+

.. _SENP2 Gene summary:

NCBI Summary
************

SUMO1 (UBL1; MIM 601912) is a small ubiquitin-like protein that can be covalently conjugated to other proteins. SENP2 is one of a group of enzymes that process newly synthesized SUMO1 into the conjugatable form and catalyze the deconjugation of SUMO1-containing species.[supplied by OMIM, Apr 2004]

.. _OMIM ID 608261
                        : http://omim.org/entry/608261
                        

.. _SENP2 OMIM Text:

OMIM
****

:OMIM ID: `OMIM ID 608261
                        `_


.. _SENP2 Phenotype:

NCBI Phenotypes
***************

No phenotypes found linked to this gene.

.. _SENP2 GO Term:

Gene Ontology
*************

* PML body
* negative regulation of protein binding
* Wnt receptor signaling pathway
* protein binding
* dorsal/ventral axis specification
* positive regulation of protein phosphorylation
* cytoplasm
* SUMO-specific protease activity
* mRNA transport
* regulation of Wnt receptor signaling pathway
* nuclear membrane
* protein domain specific binding
* proteolysis
* protein desumoylation
* nuclear pore
* protein transport

.. _SENP2 Pathway:

KEGG Pathways
*************

* `Wnt signaling pathway <http://www.genome.jp/dbget-bin/show_pathway?hsa04310+59343>`_
* `RNA transport <http://www.genome.jp/dbget-bin/show_pathway?hsa03013+59343>`_

.. _SENP2 GeneRIF:

GeneRIFs
********

* Data suggest that SENP2 regulates antiviral innate immunity by deSUMOylating IRF3 and conditioning it for ubiquitination and degradation, and provide an example of cross-talk between the ubiquitin and SUMO pathways in innate immunity. [`PMID 22028379`_]
* a mechanism underlying the SENP2-mediated regulation of Mdm2 that is critical for genome integrity in p53-dependent stress responses. [`PMID 21183956`_]
* Affinity Capture-MS [`PMID 19394292`_]
* association with the pore plays an important negative role in the regulation of SENP2 [`PMID 11896061`_]
* Affinity Capture-Western; Reconstituted Complex; Two-hybrid [`PMID 20098747`_]
* Results demonstrate that SENP1 is the most efficient SUMO protease acting on Elk-1, and that SENP3 has little effect on Elk-1. SENP2 has an intermediate effect, but its ability to activate Elk-1 is independent from its SUMO-deconjugating activity. [`PMID 20337593`_]
* The SUMO-specific isopeptidase SENP2 associates dynamically with nuclear pore complexes through interactions with karyopherins and the Nup107-160 nucleoporin subcomplex. [`PMID 22031293`_]
* SENP2 null cells display biphasic NEMO SUMOylation and activation of IKK and NF-kappaB [`PMID 21777808`_]
* Reconstituted Complex [`PMID 19953087`_]
* Reconstituted Complex [`PMID 12192048`_]
* Biochemical Activity [`PMID 12192048`_]
* Biochemical Activity [`PMID 12192048`_]
* Restricting SENP2 in the nucleus by mutations in the NES impairs its polyubiquitination, whereas a cytoplasm-localized SENP2 made by introducing mutations in the NLS can be efficiently polyubiquitinated. [`PMID 16738331`_]
* cardiac overexpression of SENP2 in the mice with Nkx2.5 haploinsufficiency promoted embryonic lethality and severity of congenital heart diseases (CHDs). [`PMID 22155005`_]
* Mutational analysis and biochemistry provide a mechanism for SENP2 substrate preferences that explains why SENP2 catalyzes SUMO deconjugation more efficiently than processing [`PMID 17099700`_]
* Two-hybrid [`PMID 16169070`_]

.. _PMID 22028379: http://www.ncbi.nlm.nih.gov/pubmed/22028379
.. _PMID 21183956: http://www.ncbi.nlm.nih.gov/pubmed/21183956
.. _PMID 19394292: http://www.ncbi.nlm.nih.gov/pubmed/19394292
.. _PMID 11896061: http://www.ncbi.nlm.nih.gov/pubmed/11896061
.. _PMID 20098747: http://www.ncbi.nlm.nih.gov/pubmed/20098747
.. _PMID 20337593: http://www.ncbi.nlm.nih.gov/pubmed/20337593
.. _PMID 22031293: http://www.ncbi.nlm.nih.gov/pubmed/22031293
.. _PMID 21777808: http://www.ncbi.nlm.nih.gov/pubmed/21777808
.. _PMID 19953087: http://www.ncbi.nlm.nih.gov/pubmed/19953087
.. _PMID 12192048: http://www.ncbi.nlm.nih.gov/pubmed/12192048
.. _PMID 16738331: http://www.ncbi.nlm.nih.gov/pubmed/16738331
.. _PMID 22155005: http://www.ncbi.nlm.nih.gov/pubmed/22155005
.. _PMID 17099700: http://www.ncbi.nlm.nih.gov/pubmed/17099700
.. _PMID 16169070: http://www.ncbi.nlm.nih.gov/pubmed/16169070

.. _SENP2 Pubmed:

PubMed Articles
***************

*Recent articles:*

* Kim EY et al. "Enhanced desumoylation in murine hearts by overexpressed SENP2 leads to congenital heart defects and cardiac dysfunction." J Mol Cell Cardiol. 2012 Mar;52(3):638-49. `PMID 22155005`_
* Goeres J et al. "The SUMO-specific isopeptidase SENP2 associates dynamically with nuclear pore complexes through interactions with karyopherins and the Nup107-160 nucleoporin subcomplex." Mol Biol Cell. 2011 Dec;22(24):4868-82. `PMID 22031293`_
* Ran Y et al. "SENP2 negatively regulates cellular antiviral response by deSUMOylating IRF3 and conditioning it for ubiquitination and degradation." J Mol Cell Biol. 2011 Oct;3(5):283-92. `PMID 22028379`_
* Lee MH et al. "NF-κB induction of the SUMO protease SENP2: A negative feedback loop to attenuate cell survival response to genotoxic stress." Mol Cell. 2011 Jul 22;43(2):180-91. `PMID 21777808`_
* Jiang M et al. "SUMO-specific protease 2 in Mdm2-mediated regulation of p53." Cell Death Differ. 2011 Jun;18(6):1005-15. `PMID 21183956`_
* Witty J et al. "SENP1 participates in the dynamic regulation of Elk-1 SUMOylation." Biochem J. 2010 May 13;428(2):247-54. `PMID 20337593`_
* Fenner BJ et al. "Expanding the substantial interactome of NEMO using protein microarrays." PLoS One. 2010 Jan 20;5(1):e8799. `PMID 20098747`_
* Persaud A et al. "Comparison of substrate specificity of the ubiquitin ligases Nedd4 and Nedd4-2 using proteome arrays." Mol Syst Biol. 2009;5:333. `PMID 19953087`_
* Ouyang J et al. "Direct binding of CoREST1 to SUMO-2/3 contributes to gene-specific repression by the LSD1/CoREST1/HDAC complex." Mol Cell. 2009 Apr 24;34(2):145-54. `PMID 19394292`_
* Barbe L et al. "Toward a confocal subcellular atlas of the human proteome." Mol Cell Proteomics. 2008 Mar;7(3):499-508. `PMID 18029348`_

.. _PMID 22028379: http://www.ncbi.nlm.nih.gov/pubmed/22028379
.. _PMID 21183956: http://www.ncbi.nlm.nih.gov/pubmed/21183956
.. _PMID 19394292: http://www.ncbi.nlm.nih.gov/pubmed/19394292
.. _PMID 20098747: http://www.ncbi.nlm.nih.gov/pubmed/20098747
.. _PMID 20337593: http://www.ncbi.nlm.nih.gov/pubmed/20337593
.. _PMID 22031293: http://www.ncbi.nlm.nih.gov/pubmed/22031293
.. _PMID 21777808: http://www.ncbi.nlm.nih.gov/pubmed/21777808
.. _PMID 19953087: http://www.ncbi.nlm.nih.gov/pubmed/19953087
.. _PMID 18029348: http://www.ncbi.nlm.nih.gov/pubmed/18029348
.. _PMID 22155005: http://www.ncbi.nlm.nih.gov/pubmed/22155005

*Top Pubmed articles linked to gene SENP2 matching any search term:* 

* Agbor TA et al. "Small ubiquitin-related modifier (SUMO)-1 promotes glycolysis in hypoxia." J Biol Chem. 2011 Feb 11;286(6):4718-26. `PMID 21123177`_

.. _PMID 21123177: http://www.ncbi.nlm.nih.gov/pubmed/21123177