.. _SLC36A4:

SLC36A4
^^^^^^^

.. contents::
   :local:

General Information
*******************

:Full gene name: solute carrier family 36 (proton/amino acid symporter), member 4
:Entrez Gene ID: 120103
:Location: 11q21
:Synonyms: PAT4
:Type: protein-coding

User SNPs
*********

SNPs given by the user that are near or inside this gene: 

+------------+---------------+------------+
|    SNP     | Distance (bp) | Direction  |
+============+===============+============+
| rs10830963 |     172140    | downstream |
+------------+---------------+------------+

.. _SLC36A4 Gene summary:

NCBI Summary
************

SLC36A4 belongs to the SLC36 family of amino acid transporters based on sequence similarity with other family members (e.g., SLC36A1; MIM 606561). SLC36 proteins contain about 500 amino acids and have 9 to 11 transmembrane domains. Unlike other SLC36 family members, which are proton-coupled amino acid transporters, SLC36A4 is a high-affinity/low-capacity non-proton-coupled amino acid transporter (Pillai and Meredith, 2011 [PubMed 21097500]).[supplied by OMIM, Feb 2011]

.. _OMIM ID 613760
                        : http://omim.org/entry/613760
                        

.. _SLC36A4 OMIM Text:

OMIM
****

:OMIM ID: `OMIM ID 613760
                        `_


.. _SLC36A4 Phenotype:

NCBI Phenotypes
***************

No phenotypes found linked to this gene.

.. _SLC36A4 GO Term:

Gene Ontology
*************

* proline transport
* tryptophan transport
* integral to membrane
* symporter activity
* L-alanine transport

.. _SLC36A4 Pathway:

KEGG Pathways
*************

No pathways found linked to this gene.

.. _SLC36A4 GeneRIF:

GeneRIFs
********

* SLC36A4 has a similar in vivo growth regulatory activity to fly SLC36 family members when expressed in Drosophila and is also required for amino acid-dependent mTORC1 activation, and mTORC1-regulated proliferation in human cells. [`PMID 20498635`_]
* SLC36A4 (hPAT4) is a high affinity amino acid transporter when expressed in Xenopus laevis oocytes. [`PMID 21097500`_]

.. _PMID 20498635: http://www.ncbi.nlm.nih.gov/pubmed/20498635
.. _PMID 21097500: http://www.ncbi.nlm.nih.gov/pubmed/21097500

.. _SLC36A4 Pubmed:

PubMed Articles
***************

*Recent articles:*

* Pillai SM et al. "SLC36A4 (hPAT4) is a high affinity amino acid transporter when expressed in Xenopus laevis oocytes." J Biol Chem. 2011 Jan 28;286(4):2455-60. `PMID 21097500`_
* Heublein S et al. "Proton-assisted amino-acid transporters are conserved regulators of proliferation and amino-acid-dependent mTORC1 activation." Oncogene. 2010 Jul 15;29(28):4068-79. `PMID 20498635`_
* Ota T et al. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat Genet. 2004 Jan;36(1):40-5. `PMID 14702039`_
* Strausberg RL et al. "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences." Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. `PMID 12477932`_

.. _PMID 14702039: http://www.ncbi.nlm.nih.gov/pubmed/14702039
.. _PMID 20498635: http://www.ncbi.nlm.nih.gov/pubmed/20498635
.. _PMID 21097500: http://www.ncbi.nlm.nih.gov/pubmed/21097500
.. _PMID 12477932: http://www.ncbi.nlm.nih.gov/pubmed/12477932