.. _SPPL3:

SPPL3
^^^^^

.. contents::
   :local:

General Information
*******************

:Full gene name: signal peptide peptidase like 3
:Entrez Gene ID: 121665
:Location: 12q24.31
:Synonyms: IMP2, MDHV1887, PRO4332, PSH1, PSL4
:Type: protein-coding

User SNPs
*********

SNPs given by the user that are near or inside this gene: 

+-----------+---------------+-----------+
|    SNP    | Distance (bp) | Direction |
+===========+===============+===========+
| rs7957197 |     118535    |  upstream |
+-----------+---------------+-----------+

.. _SPPL3 Gene summary:

NCBI Summary
************

None available.

.. _OMIM ID 608240
                        : http://omim.org/entry/608240
                        

.. _SPPL3 OMIM Text:

OMIM
****

:OMIM ID: `OMIM ID 608240
                        `_


.. _SPPL3 Phenotype:

NCBI Phenotypes
***************

* Genome-wide association studies in an isolated founder population from the Pacific Island of Kosrae.
* NHGRI GWA Catalog

.. _SPPL3 GO Term:

Gene Ontology
*************

* rough endoplasmic reticulum
* protein homodimerization activity
* aspartic endopeptidase activity, intramembrane cleaving
* integral to lumenal side of endoplasmic reticulum membrane
* integral to cytosolic side of endoplasmic reticulum membrane
* membrane protein ectodomain proteolysis
* Golgi-associated vesicle membrane

.. _SPPL3 Pathway:

KEGG Pathways
*************

No pathways found linked to this gene.

.. _SPPL3 GeneRIF:

GeneRIFs
********

* SPPL2b is targeted through the secretory pathway to endosomes/lysosomes, whereas SPP and SPPL3 are restricted to the ER. [`PMID 15998642`_]
* SPP, SPPL2a, -2b, -2c, and -3 probably cleave type II-oriented substrate peptides as shown by consensus analysis [`PMID 15385547`_]
* SPPL3 cleaves a SPP substrate, but a more distantly related homologue SPPL2b does not, providing strong evidence that the malaria SPP and human SPPL3 have conserved active sites, while the active sites SPPL2b is distinct [`PMID 16873890`_]

.. _PMID 15998642: http://www.ncbi.nlm.nih.gov/pubmed/15998642
.. _PMID 15385547: http://www.ncbi.nlm.nih.gov/pubmed/15385547
.. _PMID 16873890: http://www.ncbi.nlm.nih.gov/pubmed/16873890

.. _SPPL3 Pubmed:

PubMed Articles
***************

*Recent articles:*

* Rose JE et al. "Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score." Mol Med. 2010 Jul-Aug;16(7-8):247-53. `PMID 20379614`_
* Lowe JK et al. "Genome-wide association studies in an isolated founder population from the Pacific Island of Kosrae." PLoS Genet. 2009 Feb;5(2):e1000365. `PMID 19197348`_
* Nyborg AC et al. "Intramembrane proteolytic cleavage by human signal peptide peptidase like 3 and malaria signal peptide peptidase." FASEB J. 2006 Aug;20(10):1671-9. `PMID 16873890`_
* Friedmann E et al. "SPPL2a and SPPL2b promote intramembrane proteolysis of TNFalpha in activated dendritic cells to trigger IL-12 production." Nat Cell Biol. 2006 Aug;8(8):843-8. `PMID 16829952`_
* Krawitz P et al. "Differential localization and identification of a critical aspartate suggest non-redundant proteolytic functions of the presenilin homologues SPPL2b and SPPL3." J Biol Chem. 2005 Nov 25;280(47):39515-23. `PMID 15998642`_
* Friedmann E et al. "Consensus analysis of signal peptide peptidase and homologous human aspartic proteases reveals opposite topology of catalytic domains compared with presenilins." J Biol Chem. 2004 Dec 3;279(49):50790-8. `PMID 15385547`_
* Gerhard DS et al. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." Genome Res. 2004 Oct;14(10B):2121-7. `PMID 15489334`_
* Ota T et al. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat Genet. 2004 Jan;36(1):40-5. `PMID 14702039`_
* Clark HF et al. "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment." Genome Res. 2003 Oct;13(10):2265-70. `PMID 12975309`_
* Strausberg RL et al. "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences." Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. `PMID 12477932`_

.. _PMID 15385547: http://www.ncbi.nlm.nih.gov/pubmed/15385547
.. _PMID 15998642: http://www.ncbi.nlm.nih.gov/pubmed/15998642
.. _PMID 16873890: http://www.ncbi.nlm.nih.gov/pubmed/16873890
.. _PMID 16829952: http://www.ncbi.nlm.nih.gov/pubmed/16829952
.. _PMID 12477932: http://www.ncbi.nlm.nih.gov/pubmed/12477932
.. _PMID 12975309: http://www.ncbi.nlm.nih.gov/pubmed/12975309
.. _PMID 14702039: http://www.ncbi.nlm.nih.gov/pubmed/14702039
.. _PMID 20379614: http://www.ncbi.nlm.nih.gov/pubmed/20379614
.. _PMID 19197348: http://www.ncbi.nlm.nih.gov/pubmed/19197348
.. _PMID 15489334: http://www.ncbi.nlm.nih.gov/pubmed/15489334

*Top Pubmed articles linked to gene SPPL3 matching any search term:* 

* Lowe JK et al. "Genome-wide association studies in an isolated founder population from the Pacific Island of Kosrae." PLoS Genet. 2009 Feb;5(2):e1000365. `PMID 19197348`_

.. _PMID 19197348: http://www.ncbi.nlm.nih.gov/pubmed/19197348