.. _SRPK3:

SRPK3
^^^^^

.. contents::
   :local:

General Information
*******************

:Full gene name: SRSF protein kinase 3
:Entrez Gene ID: 26576
:Location: Xq28
:Synonyms: MSSK-1, STK23, MSSK1
:Type: protein-coding

User SNPs
*********

SNPs given by the user that are near or inside this gene: 

+-----------+---------------+-----------+
|    SNP    | Distance (bp) | Direction |
+===========+===============+===========+
| rs3020789 |     153469    |  upstream |
+-----------+---------------+-----------+

.. _SRPK3 Gene summary:

NCBI Summary
************

This gene encodes a protein kinase similar to a protein kinase which is specific for the SR (serine/arginine-rich domain) family of splicing factors. A highly similar protein has been shown to play a role in muscle development in mice. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2009]

.. _SRPK3 OMIM Text:

OMIM
****

No OMIM data available for this gene.

.. _SRPK3 Phenotype:

NCBI Phenotypes
***************

No phenotypes found linked to this gene.

.. _SRPK3 GO Term:

Gene Ontology
*************

* protein phosphorylation
* cellular_component
* cell differentiation
* muscle tissue development
* ATP binding
* skeletal muscle tissue development
* protein serine/threonine kinase activity

.. _SRPK3 Pathway:

KEGG Pathways
*************

No pathways found linked to this gene.

.. _SRPK3 GeneRIF:

GeneRIFs
********

* Affinity Capture-MS [`PMID 21139048`_]
* Affinity Capture-MS [`PMID 14559993`_]

.. _PMID 21139048: http://www.ncbi.nlm.nih.gov/pubmed/21139048
.. _PMID 14559993: http://www.ncbi.nlm.nih.gov/pubmed/14559993

.. _SRPK3 Pubmed:

PubMed Articles
***************

*Recent articles:*

* Danielsen JM et al. "Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level." Mol Cell Proteomics. 2011 Mar;10(3):M110.003590. `PMID 21139048`_
* Nakagawa O et al. "Centronuclear myopathy in mice lacking a novel muscle-specific protein kinase transcriptionally regulated by MEF2." Genes Dev. 2005 Sep 1;19(17):2066-77. `PMID 16140986`_
* Li J et al. "Regulation of alternative splicing by SRrp86 and its interacting proteins." Mol Cell Biol. 2003 Nov;23(21):7437-47. `PMID 14559993`_
* Strausberg RL et al. "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences." Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. `PMID 12477932`_
* Grunau C et al. "Large-scale methylation analysis of human genomic DNA reveals tissue-specific differences between the methylation profiles of genes and pseudogenes." Hum Mol Genet. 2000 Nov 1;9(18):2651-63. `PMID 11063724`_

.. _PMID 21139048: http://www.ncbi.nlm.nih.gov/pubmed/21139048
.. _PMID 16140986: http://www.ncbi.nlm.nih.gov/pubmed/16140986
.. _PMID 14559993: http://www.ncbi.nlm.nih.gov/pubmed/14559993
.. _PMID 11063724: http://www.ncbi.nlm.nih.gov/pubmed/11063724
.. _PMID 12477932: http://www.ncbi.nlm.nih.gov/pubmed/12477932