.. _SSR4:

SSR4
^^^^

.. contents::
   :local:

General Information
*******************

:Full gene name: signal sequence receptor, delta
:Entrez Gene ID: 6748
:Location: Xq28
:Synonyms: TRAPD
:Type: protein-coding

User SNPs
*********

SNPs given by the user that are near or inside this gene: 

+-----------+---------------+-----------+
|    SNP    | Distance (bp) | Direction |
+===========+===============+===========+
| rs3020789 |     166643    |  upstream |
+-----------+---------------+-----------+

.. _SSR4 Gene summary:

NCBI Summary
************

This gene encodes the delta subunit of the translocon-associated protein complex which is involved in translocating proteins across the endoplasmic reticulum membrane. The encoded protein is located in the Xq28 region and is arranged in a compact head-to-head manner with the isocitrate dehydrogenase 3 (NAD+) gamma gene and both genes are driven by a CpG-embedded bidirectional promoter. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Mar 2011]

.. _OMIM ID 300090
                        : http://omim.org/entry/300090
                        

.. _SSR4 OMIM Text:

OMIM
****

:OMIM ID: `OMIM ID 300090
                        `_


.. _SSR4 Phenotype:

NCBI Phenotypes
***************

No phenotypes found linked to this gene.

.. _SSR4 GO Term:

Gene Ontology
*************

* calcium ion binding
* cellular protein metabolic process
* Sec61 translocon complex
* SRP-dependent cotranslational protein targeting to membrane
* integral to membrane
* translation
* intracellular protein transport
* gene expression

.. _SSR4 Pathway:

KEGG Pathways
*************

* `Protein processing in endoplasmic reticulum <http://www.genome.jp/dbget-bin/show_pathway?hsa04141+6748>`_

.. _SSR4 GeneRIF:

GeneRIFs
********

* Affinity Capture-MS [`PMID 17314511`_]
* results of this study implicate TRAPD as a candidate gene with potential functions that might be associated with ultraviolet-induced melanomagenesis and metastasis [`PMID 15057039`_]
* Affinity Capture-MS [`PMID 17353931`_]
* Affinity Capture-MS [`PMID 17353931`_]
* Affinity Capture-MS [`PMID 17353931`_]
* Affinity Capture-MS [`PMID 17353931`_]
* Affinity Capture-MS [`PMID 17342744`_]
* Affinity Capture-Western [`PMID 14684739`_]
* Affinity Capture-Western [`PMID 14684739`_]
* Affinity Capture-MS [`PMID 21987572`_]

.. _PMID 17314511: http://www.ncbi.nlm.nih.gov/pubmed/17314511
.. _PMID 15057039: http://www.ncbi.nlm.nih.gov/pubmed/15057039
.. _PMID 17353931: http://www.ncbi.nlm.nih.gov/pubmed/17353931
.. _PMID 17342744: http://www.ncbi.nlm.nih.gov/pubmed/17342744
.. _PMID 14684739: http://www.ncbi.nlm.nih.gov/pubmed/14684739
.. _PMID 21987572: http://www.ncbi.nlm.nih.gov/pubmed/21987572

.. _SSR4 Pubmed:

PubMed Articles
***************

*Recent articles:*

* Lee KA et al. "Ubiquitin ligase substrate identification through quantitative proteomics at both the protein and peptide levels." J Biol Chem. 2011 Dec 2;286(48):41530-8. `PMID 21987572`_
* Kim W et al. "Systematic and quantitative assessment of the ubiquitin-modified proteome." Mol Cell. 2011 Oct 21;44(2):325-40. `PMID 21906983`_
* Wagner SA et al. "A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles." Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. `PMID 21890473`_
* Shi Y et al. "A data set of human endogenous protein ubiquitination sites." Mol Cell Proteomics. 2011 May;10(5):M110.002089. `PMID 20972266`_
* Danielsen JM et al. "Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level." Mol Cell Proteomics. 2011 Mar;10(3):M110.003590. `PMID 21139048`_
* Xu G et al. "Global analysis of lysine ubiquitination by ubiquitin remnant immunoaffinity profiling." Nat Biotechnol. 2010 Aug;28(8):868-73. `PMID 20639865`_
* Meierhofer D et al. "Quantitative analysis of global ubiquitination in HeLa cells by mass spectrometry." J Proteome Res. 2008 Oct;7(10):4566-76. `PMID 18781797`_
* Dall'Era MA et al. "HSP27 and HSP70 interact with CD10 in C4-2 prostate cancer cells." Prostate. 2007 May 15;67(7):714-21. `PMID 17342744`_
* Ewing RM et al. "Large-scale mapping of human protein-protein interactions by mass spectrometry." Mol Syst Biol. 2007;3:89. `PMID 17353931`_
* Koch HB et al. "Large-scale identification of c-MYC-associated proteins using a combined TAP/MudPIT approach." Cell Cycle. 2007 Jan 15;6(2):205-17. `PMID 17314511`_

.. _PMID 21890473: http://www.ncbi.nlm.nih.gov/pubmed/21890473
.. _PMID 20639865: http://www.ncbi.nlm.nih.gov/pubmed/20639865
.. _PMID 17314511: http://www.ncbi.nlm.nih.gov/pubmed/17314511
.. _PMID 17353931: http://www.ncbi.nlm.nih.gov/pubmed/17353931
.. _PMID 18781797: http://www.ncbi.nlm.nih.gov/pubmed/18781797
.. _PMID 17342744: http://www.ncbi.nlm.nih.gov/pubmed/17342744
.. _PMID 20972266: http://www.ncbi.nlm.nih.gov/pubmed/20972266
.. _PMID 21139048: http://www.ncbi.nlm.nih.gov/pubmed/21139048
.. _PMID 21987572: http://www.ncbi.nlm.nih.gov/pubmed/21987572
.. _PMID 21906983: http://www.ncbi.nlm.nih.gov/pubmed/21906983

*Top Pubmed articles linked to gene SSR4 matching any search term:* 

* Dodson G et al. "The role of assembly in insulin's biosynthesis." Curr Opin Struct Biol. 1998 Apr;8(2):189-94. `PMID 9631292`_

.. _PMID 9631292: http://www.ncbi.nlm.nih.gov/pubmed/9631292